Lipid profile in women of different ethnicity with gestational diabetes: Relationship with fetal growth
Abstract Aims/Introduction Pregnancy complicated by gestational diabetes mellitus (GDM) is characterized by excessive insulin resistance that impairs the metabolism of glucose and lipids. the aim of the study was to examine lipid profiles during pregnancy of women with GDM, and its impact on fetal g...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.14124 |
| _version_ | 1797289298292113408 |
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| author | Maria Grazia Dalfrà Silvia Burlina Eugenio Ragazzi Silvia Pastrolin Giovanni Sartore Annunziata Lapolla |
| author_facet | Maria Grazia Dalfrà Silvia Burlina Eugenio Ragazzi Silvia Pastrolin Giovanni Sartore Annunziata Lapolla |
| author_sort | Maria Grazia Dalfrà |
| collection | DOAJ |
| description | Abstract Aims/Introduction Pregnancy complicated by gestational diabetes mellitus (GDM) is characterized by excessive insulin resistance that impairs the metabolism of glucose and lipids. the aim of the study was to examine lipid profiles during pregnancy of women with GDM, and its impact on fetal growth in a multiethnic population. Materials and Methods The study included 322 pregnant women of different ethnicity with GDM attending a clinical unit specializing in metabolic diseases. Results The area under the curve for the 75‐g oral glucose tolerance test and glycated hemoglobin were significantly different among all groups. At the time of being diagnosed with GDM, Asian and African mothers had significantly lower levels of total and low‐density liprotein cholesterol than European mothers (P < 0.001). The trend for high‐density liprotein cholesterol was similar. Triglycerides levels in the Asian group (193.6 ± 65.5 mg/dL) were higher than in the African group (133.2 ± 49.6 mg/dL, P < 0.001), whereas the European group presented intermediate values (175.8 ± 58.8 mg/dL), which differed significantly only versus the African group (P < 0.001). Pre‐partum lipid profiles showed a trend quite similar to that observed at diagnosis. The newborn's birthweight was significantly different, with that of African women (3,437 ± 503 g) being the highest, followed by that of European women (3,294 ± 455 g) and of Asian women (3,006 ± 513 g). The rates of macrosomia showed a trend with higher values in the African group (13.5%), followed by the European group (5.7%, P = 0.1162), whereas that of the Asian group was zero (P = 0.0023 vs African). Conclusions Our data show that lipid profiles in women with GDM differ by ethnicity. The impact of lipid profile on fetal growth is limited and uninfluenced by ethnicity. |
| first_indexed | 2024-03-07T19:02:56Z |
| format | Article |
| id | doaj.art-f8bdc382bf7e42a5af7b5b2d20254dac |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-03-07T19:02:56Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-f8bdc382bf7e42a5af7b5b2d20254dac2024-03-01T12:52:01ZengWileyJournal of Diabetes Investigation2040-11162040-11242024-03-0115335536310.1111/jdi.14124Lipid profile in women of different ethnicity with gestational diabetes: Relationship with fetal growthMaria Grazia Dalfrà0Silvia Burlina1Eugenio Ragazzi2Silvia Pastrolin3Giovanni Sartore4Annunziata Lapolla5Department of Medicine – DIMED University of Padova Padova ItalyDepartment of Medicine – DIMED University of Padova Padova ItalyDepartment of Pharmaceutical and Pharmacological Sciences University of Padova Padova ItalyDepartment of Medicine – DIMED University of Padova Padova ItalyDepartment of Medicine – DIMED University of Padova Padova ItalyDepartment of Medicine – DIMED University of Padova Padova ItalyAbstract Aims/Introduction Pregnancy complicated by gestational diabetes mellitus (GDM) is characterized by excessive insulin resistance that impairs the metabolism of glucose and lipids. the aim of the study was to examine lipid profiles during pregnancy of women with GDM, and its impact on fetal growth in a multiethnic population. Materials and Methods The study included 322 pregnant women of different ethnicity with GDM attending a clinical unit specializing in metabolic diseases. Results The area under the curve for the 75‐g oral glucose tolerance test and glycated hemoglobin were significantly different among all groups. At the time of being diagnosed with GDM, Asian and African mothers had significantly lower levels of total and low‐density liprotein cholesterol than European mothers (P < 0.001). The trend for high‐density liprotein cholesterol was similar. Triglycerides levels in the Asian group (193.6 ± 65.5 mg/dL) were higher than in the African group (133.2 ± 49.6 mg/dL, P < 0.001), whereas the European group presented intermediate values (175.8 ± 58.8 mg/dL), which differed significantly only versus the African group (P < 0.001). Pre‐partum lipid profiles showed a trend quite similar to that observed at diagnosis. The newborn's birthweight was significantly different, with that of African women (3,437 ± 503 g) being the highest, followed by that of European women (3,294 ± 455 g) and of Asian women (3,006 ± 513 g). The rates of macrosomia showed a trend with higher values in the African group (13.5%), followed by the European group (5.7%, P = 0.1162), whereas that of the Asian group was zero (P = 0.0023 vs African). Conclusions Our data show that lipid profiles in women with GDM differ by ethnicity. The impact of lipid profile on fetal growth is limited and uninfluenced by ethnicity.https://doi.org/10.1111/jdi.14124EthnicityGestational diabetes mellitusLipid profile |
| spellingShingle | Maria Grazia Dalfrà Silvia Burlina Eugenio Ragazzi Silvia Pastrolin Giovanni Sartore Annunziata Lapolla Lipid profile in women of different ethnicity with gestational diabetes: Relationship with fetal growth Journal of Diabetes Investigation Ethnicity Gestational diabetes mellitus Lipid profile |
| title | Lipid profile in women of different ethnicity with gestational diabetes: Relationship with fetal growth |
| title_full | Lipid profile in women of different ethnicity with gestational diabetes: Relationship with fetal growth |
| title_fullStr | Lipid profile in women of different ethnicity with gestational diabetes: Relationship with fetal growth |
| title_full_unstemmed | Lipid profile in women of different ethnicity with gestational diabetes: Relationship with fetal growth |
| title_short | Lipid profile in women of different ethnicity with gestational diabetes: Relationship with fetal growth |
| title_sort | lipid profile in women of different ethnicity with gestational diabetes relationship with fetal growth |
| topic | Ethnicity Gestational diabetes mellitus Lipid profile |
| url | https://doi.org/10.1111/jdi.14124 |
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