Exosome-associated host–pathogen interaction: a potential effect of biofilm formation
Abstract Exosomes being non-ionized micro-vesicles with a size range of 30–100 nm possess the ability to bring about intracellular communication and intercellular transport of various types of cellular components like miRNA, mRNA, DNA, and proteins. This is achieved through the targeted transmission...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-11-01
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| Series: | Journal of Analytical Science and Technology |
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| Online Access: | https://doi.org/10.1186/s40543-021-00306-1 |
| _version_ | 1818837782086287360 |
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| author | Dibyajit Lahiri Moupriya Nag Ankita Dey Tanmay Sarkar Smaranika Pattnaik Sougata Ghosh Hisham Atan Edinur Siddhartha Pati Zulhisyam Abdul Kari Rina Rani Ray |
| author_facet | Dibyajit Lahiri Moupriya Nag Ankita Dey Tanmay Sarkar Smaranika Pattnaik Sougata Ghosh Hisham Atan Edinur Siddhartha Pati Zulhisyam Abdul Kari Rina Rani Ray |
| author_sort | Dibyajit Lahiri |
| collection | DOAJ |
| description | Abstract Exosomes being non-ionized micro-vesicles with a size range of 30–100 nm possess the ability to bring about intracellular communication and intercellular transport of various types of cellular components like miRNA, mRNA, DNA, and proteins. This is achieved through the targeted transmission of various inclusions to nearby or distant tissues. This is associated with the effective communication of information to bring about changes in physiological properties and functional attributes. The extracellular vesicles (EVs), produced by fungi, parasites, and bacteria, are responsible to bring about modulation/alteration of the immune responses exerted by the host body. The lipids, nucleic acids, proteins, and glycans of EVs derived from the pathogens act as the ligands of different families of pattern recognition receptors of the host body. The bacterial membrane vesicles (BMVs) are responsible for the transfer of small RNA species, along with other types of noncoding RNA thereby playing a key role in the regulation of the host immune system. Apart from immunomodulation, the BMVs are also responsible for bacterial colonization in the host tissue, biofilm formation, and survival therein showing antibiotic resistance, leading to pathogenesis and virulence. This mini-review would focus on the role of exosomes in the development of biofilm and consequent immunological responses within the host body along with an analysis of the mechanism associated with the development of resistance. |
| first_indexed | 2024-12-19T03:27:58Z |
| format | Article |
| id | doaj.art-f8c1e7ec0857405680f062ea231490a5 |
| institution | Directory Open Access Journal |
| issn | 2093-3371 |
| language | English |
| last_indexed | 2024-12-19T03:27:58Z |
| publishDate | 2021-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Analytical Science and Technology |
| spelling | doaj.art-f8c1e7ec0857405680f062ea231490a52022-12-21T20:37:33ZengSpringerOpenJournal of Analytical Science and Technology2093-33712021-11-011211810.1186/s40543-021-00306-1Exosome-associated host–pathogen interaction: a potential effect of biofilm formationDibyajit Lahiri0Moupriya Nag1Ankita Dey2Tanmay Sarkar3Smaranika Pattnaik4Sougata Ghosh5Hisham Atan Edinur6Siddhartha Pati7Zulhisyam Abdul Kari8Rina Rani Ray9Department of Biotechnology, University of Engineering and ManagementDepartment of Biotechnology, University of Engineering and ManagementDepartment of Biotechnology, Maulana Abul Kalam Azad University of Technology, West BengalDepartment of Food Technology and Biochemical Engineering, Faculty of Engineering and Technology, Jadavpur UniversityDepartment of Biotechnology and Bioinformatics, Sambalpur UniversityDepartment of Microbiology, School of Science, R.K. UniversityForensic Science Programme, School of Health Sciences, Universiti Sains MalaysiaResearch Division, Association for Biodiversity Conservation and Research (ABC)Faculty of Agro Based Industry, Universiti Malaysia KelantanDepartment of Biotechnology, Maulana Abul Kalam Azad University of Technology, West BengalAbstract Exosomes being non-ionized micro-vesicles with a size range of 30–100 nm possess the ability to bring about intracellular communication and intercellular transport of various types of cellular components like miRNA, mRNA, DNA, and proteins. This is achieved through the targeted transmission of various inclusions to nearby or distant tissues. This is associated with the effective communication of information to bring about changes in physiological properties and functional attributes. The extracellular vesicles (EVs), produced by fungi, parasites, and bacteria, are responsible to bring about modulation/alteration of the immune responses exerted by the host body. The lipids, nucleic acids, proteins, and glycans of EVs derived from the pathogens act as the ligands of different families of pattern recognition receptors of the host body. The bacterial membrane vesicles (BMVs) are responsible for the transfer of small RNA species, along with other types of noncoding RNA thereby playing a key role in the regulation of the host immune system. Apart from immunomodulation, the BMVs are also responsible for bacterial colonization in the host tissue, biofilm formation, and survival therein showing antibiotic resistance, leading to pathogenesis and virulence. This mini-review would focus on the role of exosomes in the development of biofilm and consequent immunological responses within the host body along with an analysis of the mechanism associated with the development of resistance.https://doi.org/10.1186/s40543-021-00306-1ExosomesMembrane vesiclesImmunogenic responseBiofilmResistanceBioprospecting |
| spellingShingle | Dibyajit Lahiri Moupriya Nag Ankita Dey Tanmay Sarkar Smaranika Pattnaik Sougata Ghosh Hisham Atan Edinur Siddhartha Pati Zulhisyam Abdul Kari Rina Rani Ray Exosome-associated host–pathogen interaction: a potential effect of biofilm formation Journal of Analytical Science and Technology Exosomes Membrane vesicles Immunogenic response Biofilm Resistance Bioprospecting |
| title | Exosome-associated host–pathogen interaction: a potential effect of biofilm formation |
| title_full | Exosome-associated host–pathogen interaction: a potential effect of biofilm formation |
| title_fullStr | Exosome-associated host–pathogen interaction: a potential effect of biofilm formation |
| title_full_unstemmed | Exosome-associated host–pathogen interaction: a potential effect of biofilm formation |
| title_short | Exosome-associated host–pathogen interaction: a potential effect of biofilm formation |
| title_sort | exosome associated host pathogen interaction a potential effect of biofilm formation |
| topic | Exosomes Membrane vesicles Immunogenic response Biofilm Resistance Bioprospecting |
| url | https://doi.org/10.1186/s40543-021-00306-1 |
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