Three-year and five-year outcomes of surgical resection for pancreatic ductal adenocarcinoma: Long-term experiences in one medical center
Objective: Pancreatic ductal adenocarcinoma is one of the most malignant types of cancer. This study evaluated the 3-year and 5-year surgical outcomes associated with the cancer and determined whether statistically identified factors can be used to predict survival. Methods: This retrospective revie...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-03-01
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| Series: | Asian Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958416300860 |
| _version_ | 1818345677500973056 |
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| author | Chih-Po Hsu Jun-Te Hsu Chien-Hung Liao Shih-Ching Kang Being-Chuan Lin Yu-Pao Hsu Chun-Nan Yeh Ta-Sen Yeh Tsann-Long Hwang |
| author_facet | Chih-Po Hsu Jun-Te Hsu Chien-Hung Liao Shih-Ching Kang Being-Chuan Lin Yu-Pao Hsu Chun-Nan Yeh Ta-Sen Yeh Tsann-Long Hwang |
| author_sort | Chih-Po Hsu |
| collection | DOAJ |
| description | Objective: Pancreatic ductal adenocarcinoma is one of the most malignant types of cancer. This study evaluated the 3-year and 5-year surgical outcomes associated with the cancer and determined whether statistically identified factors can be used to predict survival.
Methods: This retrospective review was conducted from 1995 to 2010. Patients who had resectable pancreatic ductal adenocarcinoma and received surgical treatment were included. Cases of hospital mortality were excluded. The relationships between several clinicopathological factors and the survival rate were analyzed.
Results: A total of 223 patients were included in this study. The 3-year and 5-year survival rates were 21.4% and 10.1%, respectively, and the median survival was 16.1 months. Tumor size, N status, and resection margins were independent predictive factors for 3-year survival. Tumor size independently predicted 5-year survival.
Conclusion: Tumor size is the most important independent prognostic factor for 3-year and 5-year survival. Lymph node status and the resection margins also independently affected the 3-year survival. These patient outcomes might be improved by early diagnosis and radical resection. Future studies should focus on the tumor biology of this aggressive cancer. |
| first_indexed | 2024-12-13T17:06:10Z |
| format | Article |
| id | doaj.art-f8c21f6b69dc44a3b508951d42835c2f |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-13T17:06:10Z |
| publishDate | 2018-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-f8c21f6b69dc44a3b508951d42835c2f2022-12-21T23:37:40ZengElsevierAsian Journal of Surgery1015-95842018-03-0141211512310.1016/j.asjsur.2016.11.009Three-year and five-year outcomes of surgical resection for pancreatic ductal adenocarcinoma: Long-term experiences in one medical centerChih-Po HsuJun-Te HsuChien-Hung LiaoShih-Ching KangBeing-Chuan LinYu-Pao HsuChun-Nan YehTa-Sen YehTsann-Long HwangObjective: Pancreatic ductal adenocarcinoma is one of the most malignant types of cancer. This study evaluated the 3-year and 5-year surgical outcomes associated with the cancer and determined whether statistically identified factors can be used to predict survival. Methods: This retrospective review was conducted from 1995 to 2010. Patients who had resectable pancreatic ductal adenocarcinoma and received surgical treatment were included. Cases of hospital mortality were excluded. The relationships between several clinicopathological factors and the survival rate were analyzed. Results: A total of 223 patients were included in this study. The 3-year and 5-year survival rates were 21.4% and 10.1%, respectively, and the median survival was 16.1 months. Tumor size, N status, and resection margins were independent predictive factors for 3-year survival. Tumor size independently predicted 5-year survival. Conclusion: Tumor size is the most important independent prognostic factor for 3-year and 5-year survival. Lymph node status and the resection margins also independently affected the 3-year survival. These patient outcomes might be improved by early diagnosis and radical resection. Future studies should focus on the tumor biology of this aggressive cancer.http://www.sciencedirect.com/science/article/pii/S1015958416300860outcomespancreatic ductal adenocarcinomaprognostic factorssurgical resection |
| spellingShingle | Chih-Po Hsu Jun-Te Hsu Chien-Hung Liao Shih-Ching Kang Being-Chuan Lin Yu-Pao Hsu Chun-Nan Yeh Ta-Sen Yeh Tsann-Long Hwang Three-year and five-year outcomes of surgical resection for pancreatic ductal adenocarcinoma: Long-term experiences in one medical center Asian Journal of Surgery outcomes pancreatic ductal adenocarcinoma prognostic factors surgical resection |
| title | Three-year and five-year outcomes of surgical resection for pancreatic ductal adenocarcinoma: Long-term experiences in one medical center |
| title_full | Three-year and five-year outcomes of surgical resection for pancreatic ductal adenocarcinoma: Long-term experiences in one medical center |
| title_fullStr | Three-year and five-year outcomes of surgical resection for pancreatic ductal adenocarcinoma: Long-term experiences in one medical center |
| title_full_unstemmed | Three-year and five-year outcomes of surgical resection for pancreatic ductal adenocarcinoma: Long-term experiences in one medical center |
| title_short | Three-year and five-year outcomes of surgical resection for pancreatic ductal adenocarcinoma: Long-term experiences in one medical center |
| title_sort | three year and five year outcomes of surgical resection for pancreatic ductal adenocarcinoma long term experiences in one medical center |
| topic | outcomes pancreatic ductal adenocarcinoma prognostic factors surgical resection |
| url | http://www.sciencedirect.com/science/article/pii/S1015958416300860 |
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