Upregulation of TRPM3 in nociceptors innervating inflamed tissue

Upregulation of TRPM3 in nociceptors innervating inflamed tissue

Genetic ablation or pharmacological inhibition of the heat-activated cation channel TRPM3 alleviates inflammatory heat hyperalgesia, but the underlying mechanisms are unknown. We induced unilateral inflammation of the hind paw in mice, and directly compared expression and function of TRPM3 and two o...

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Bibliographic Details
Main Authors: Marie Mulier, Nele Van Ranst, Nikky Corthout, Sebastian Munck, Pieter Vanden Berghe, Joris Vriens, Thomas Voets, Lauri Moilanen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
TRP channels
inflammatory pain
sensory neurons
Online Access:https://elifesciences.org/articles/61103

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