Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?
Endometrial cancer is one of the most common gynecological malignancies, yet the molecular mechanisms that lead to tumor development and progression are still not fully established. Matrix metalloproteinases (MMPs) are a group of enzymes that play an important role in carcinogenesis. They are protea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/22/12472 |
| _version_ | 1797510033518362624 |
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| author | Kaja Michalczyk Aneta Cymbaluk-Płoska |
| author_facet | Kaja Michalczyk Aneta Cymbaluk-Płoska |
| author_sort | Kaja Michalczyk |
| collection | DOAJ |
| description | Endometrial cancer is one of the most common gynecological malignancies, yet the molecular mechanisms that lead to tumor development and progression are still not fully established. Matrix metalloproteinases (MMPs) are a group of enzymes that play an important role in carcinogenesis. They are proteases involved in the degradation of the extracellular matrix (ECM) that surrounds the tumor and the affected tissue allows cell detachment from the primary tumor causing local invasion and metastasis formation. Recent investigations demonstrate significantly increased metalloproteinase and metalloproteinase inhibitor levels in patients with endometrial cancer compared to those with normal endometrium. In this review, we aim to show their clinical significance and possible use in the diagnosis and treatment of patients with endometrial cancer. We have critically summarized and reviewed the research on the role of MMPs in endometrial cancer. |
| first_indexed | 2024-03-10T05:26:10Z |
| format | Article |
| id | doaj.art-f8c7a91c8cef4674bf5bb1d81044bad4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T05:26:10Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f8c7a91c8cef4674bf5bb1d81044bad42023-11-22T23:42:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122221247210.3390/ijms222212472Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?Kaja Michalczyk0Aneta Cymbaluk-Płoska1Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandEndometrial cancer is one of the most common gynecological malignancies, yet the molecular mechanisms that lead to tumor development and progression are still not fully established. Matrix metalloproteinases (MMPs) are a group of enzymes that play an important role in carcinogenesis. They are proteases involved in the degradation of the extracellular matrix (ECM) that surrounds the tumor and the affected tissue allows cell detachment from the primary tumor causing local invasion and metastasis formation. Recent investigations demonstrate significantly increased metalloproteinase and metalloproteinase inhibitor levels in patients with endometrial cancer compared to those with normal endometrium. In this review, we aim to show their clinical significance and possible use in the diagnosis and treatment of patients with endometrial cancer. We have critically summarized and reviewed the research on the role of MMPs in endometrial cancer.https://www.mdpi.com/1422-0067/22/22/12472metalloproteinasesMMPTIMPendometrial cancercancer |
| spellingShingle | Kaja Michalczyk Aneta Cymbaluk-Płoska Metalloproteinases in Endometrial Cancer—Are They Worth Measuring? International Journal of Molecular Sciences metalloproteinases MMP TIMP endometrial cancer cancer |
| title | Metalloproteinases in Endometrial Cancer—Are They Worth Measuring? |
| title_full | Metalloproteinases in Endometrial Cancer—Are They Worth Measuring? |
| title_fullStr | Metalloproteinases in Endometrial Cancer—Are They Worth Measuring? |
| title_full_unstemmed | Metalloproteinases in Endometrial Cancer—Are They Worth Measuring? |
| title_short | Metalloproteinases in Endometrial Cancer—Are They Worth Measuring? |
| title_sort | metalloproteinases in endometrial cancer are they worth measuring |
| topic | metalloproteinases MMP TIMP endometrial cancer cancer |
| url | https://www.mdpi.com/1422-0067/22/22/12472 |
| work_keys_str_mv | AT kajamichalczyk metalloproteinasesinendometrialcanceraretheyworthmeasuring AT anetacymbalukpłoska metalloproteinasesinendometrialcanceraretheyworthmeasuring |