ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand

ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand

The regulation and mechanisms underlying itch sensation are complex. Here, we report a role for acid-sensing ion channel 3 (ASIC3) in mediating itch evoked by certain pruritogens during tissue acidosis. Co-administration of acid with Ser-Leu-Ile-Gly-Arg-Leu-NH2 (SL-NH2) increased scratching behavior...

Full description

Bibliographic Details
Main Authors: Zhong Peng, Wei-Guang Li, Chen Huang, Yi-Ming Jiang, Xiang Wang, Michael Xi Zhu, Xiaoyang Cheng, Tian-Le Xu
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471501013X

Similar Items

Similar Items