Purine Nucleotides Metabolism and Signaling in Huntington’s Disease: Search for a Target for Novel Therapies

Purine Nucleotides Metabolism and Signaling in Huntington’s Disease: Search for a Target for Novel Therapies

Huntington’s disease (HD) is a multi-system disorder that is caused by expanded CAG repeats within the exon-1 of the huntingtin (<i>HTT</i>) gene that translate to the polyglutamine stretch in the HTT protein. HTT interacts with the proteins involved in gene transcription, endocytosis, a...

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Bibliographic Details
Main Authors: Marta Tomczyk, Talita Glaser, Ewa M. Slominska, Henning Ulrich, Ryszard T. Smolenski
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
purine metabolism
purinergic signaling
Huntington’s disease
Online Access:https://www.mdpi.com/1422-0067/22/12/6545

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