Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats
The effect of sodium-glucose cotransporter 2 inhibitors on peripheral nerves and kidneys in diabetes mellitus (DM) remains unexplored. Therefore, this study aimed to explore the effect of empagliflozin in diabetic rats. DM in rats was induced by streptozotocin injection, and diabetic rats were treat...
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2018-04-01
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| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-42-338.pdf |
| _version_ | 1811277352531918848 |
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| author | Kyung Ae Lee Heung Yong Jin Na Young Lee Yu Ji Kim Tae Sun Park |
| author_facet | Kyung Ae Lee Heung Yong Jin Na Young Lee Yu Ji Kim Tae Sun Park |
| author_sort | Kyung Ae Lee |
| collection | DOAJ |
| description | The effect of sodium-glucose cotransporter 2 inhibitors on peripheral nerves and kidneys in diabetes mellitus (DM) remains unexplored. Therefore, this study aimed to explore the effect of empagliflozin in diabetic rats. DM in rats was induced by streptozotocin injection, and diabetic rats were treated with empagliflozin 3 or 10 mg/kg. Following 24-week treatment, response thresholds to four different stimuli were tested and found to be lower in diabetic rats than in normal rats. Empagliflozin significantly prevented hypersensitivity (P<0.05) and the loss of skin intraepidermal nerve fibers, and mesangial matrix expansion in diabetic rats. Results of this study demonstrate the potential therapeutic effects of empagliflozin for the treatment of diabetic peripheral neuropathy and nephropathy. |
| first_indexed | 2024-04-13T00:14:13Z |
| format | Article |
| id | doaj.art-f8caad647f88427ea01993ec218efed1 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-04-13T00:14:13Z |
| publishDate | 2018-04-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-f8caad647f88427ea01993ec218efed12022-12-22T03:10:59ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872018-04-0142433834210.4093/dmj.2017.0095Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic RatsKyung Ae LeeHeung Yong JinNa Young LeeYu Ji KimTae Sun ParkThe effect of sodium-glucose cotransporter 2 inhibitors on peripheral nerves and kidneys in diabetes mellitus (DM) remains unexplored. Therefore, this study aimed to explore the effect of empagliflozin in diabetic rats. DM in rats was induced by streptozotocin injection, and diabetic rats were treated with empagliflozin 3 or 10 mg/kg. Following 24-week treatment, response thresholds to four different stimuli were tested and found to be lower in diabetic rats than in normal rats. Empagliflozin significantly prevented hypersensitivity (P<0.05) and the loss of skin intraepidermal nerve fibers, and mesangial matrix expansion in diabetic rats. Results of this study demonstrate the potential therapeutic effects of empagliflozin for the treatment of diabetic peripheral neuropathy and nephropathy.https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-42-338.pdfDiabetes mellitus, experimentalDiabetic nephropathiesDiabetic neuropathiesPeripheral nervesSodium-glucose transporter 2 |
| spellingShingle | Kyung Ae Lee Heung Yong Jin Na Young Lee Yu Ji Kim Tae Sun Park Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats Diabetes & Metabolism Journal Diabetes mellitus, experimental Diabetic nephropathies Diabetic neuropathies Peripheral nerves Sodium-glucose transporter 2 |
| title | Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats |
| title_full | Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats |
| title_fullStr | Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats |
| title_full_unstemmed | Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats |
| title_short | Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats |
| title_sort | effect of empagliflozin a selective sodium glucose cotransporter 2 inhibitor on kidney and peripheral nerves in streptozotocin induced diabetic rats |
| topic | Diabetes mellitus, experimental Diabetic nephropathies Diabetic neuropathies Peripheral nerves Sodium-glucose transporter 2 |
| url | https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-42-338.pdf |
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