Osteoporosis Is Associated with an Increased Risk of Colorectal Neoplasms Regardless of Sex: Nationwide Population-Based Cohort Study
Vitamin D may have anticancer effects against colorectal cancer (CRC). Bone mineral density (BMD) reflects the long-term vitamin D status. This study investigated the association between osteoporosis and colorectal neoplasms (CRN). The data were obtained from the National Health Insurance Service sa...
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MDPI AG
2024-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/14/6/666 |
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| author | Seung Heon Yoo Ji Hyung Nam Dong Jun Oh Geun U Park Sang Hoon Kim Hyoun Woo Kang Jae Hak Kim Yun Jeong Lim |
| author_facet | Seung Heon Yoo Ji Hyung Nam Dong Jun Oh Geun U Park Sang Hoon Kim Hyoun Woo Kang Jae Hak Kim Yun Jeong Lim |
| author_sort | Seung Heon Yoo |
| collection | DOAJ |
| description | Vitamin D may have anticancer effects against colorectal cancer (CRC). Bone mineral density (BMD) reflects the long-term vitamin D status. This study investigated the association between osteoporosis and colorectal neoplasms (CRN). The data were obtained from the National Health Insurance Service sample cohort, which included 60,386 osteoporosis patients and 8224 controls who underwent BMD in 2002–2019. The logistic regression models included age, sex, income level, and comorbidity. Sensitivity tests were performed using the data from the National Health Screening Program. In total, 7706 (11.2%) patients were diagnosed with CRN, and the proportion was significantly higher in osteoporosis patients than in controls (11.7% vs. 8.1%). In the multivariate analysis, osteoporosis was associated with an increased risk of CRN (odds ratio (OR) = 1.91, 95% confidence interval = 1.75–2.09, <i>p</i> < 0.0001), which was significant for both colorectal adenomas and CRC (OR = 1.88 and 1.83, respectively). A subgroup analysis by sex revealed a significant association between osteoporosis and CRN in both women and men (OR = 2.06 and 1.66, respectively). The sensitivity tests revealed results similar to those of the original dataset. In conclusion, osteoporosis is significantly associated with CRN risk in both sexes. In high-risk patients with low BMD, appropriate screening for CRN and vitamin D supplementation are required, regardless of sex. |
| first_indexed | 2024-04-24T18:24:06Z |
| format | Article |
| id | doaj.art-f8cbe13870434aa49466a42a9d01f1a9 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-24T18:24:06Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-f8cbe13870434aa49466a42a9d01f1a92024-03-27T13:33:29ZengMDPI AGDiagnostics2075-44182024-03-0114666610.3390/diagnostics14060666Osteoporosis Is Associated with an Increased Risk of Colorectal Neoplasms Regardless of Sex: Nationwide Population-Based Cohort StudySeung Heon Yoo0Ji Hyung Nam1Dong Jun Oh2Geun U Park3Sang Hoon Kim4Hyoun Woo Kang5Jae Hak Kim6Yun Jeong Lim7Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang 10326, Republic of KoreaDepartment of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang 10326, Republic of KoreaDepartment of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang 10326, Republic of KoreaGN Co., Seoul 05051, Republic of KoreaDepartment of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Chung-ang University College of Medicine, Gwangmyeong 14353, Republic of KoreaDepartment of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, Republic of KoreaDepartment of Internal Medicine, Myongji Hospital, Goyang 10475, Republic of KoreaDepartment of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang 10326, Republic of KoreaVitamin D may have anticancer effects against colorectal cancer (CRC). Bone mineral density (BMD) reflects the long-term vitamin D status. This study investigated the association between osteoporosis and colorectal neoplasms (CRN). The data were obtained from the National Health Insurance Service sample cohort, which included 60,386 osteoporosis patients and 8224 controls who underwent BMD in 2002–2019. The logistic regression models included age, sex, income level, and comorbidity. Sensitivity tests were performed using the data from the National Health Screening Program. In total, 7706 (11.2%) patients were diagnosed with CRN, and the proportion was significantly higher in osteoporosis patients than in controls (11.7% vs. 8.1%). In the multivariate analysis, osteoporosis was associated with an increased risk of CRN (odds ratio (OR) = 1.91, 95% confidence interval = 1.75–2.09, <i>p</i> < 0.0001), which was significant for both colorectal adenomas and CRC (OR = 1.88 and 1.83, respectively). A subgroup analysis by sex revealed a significant association between osteoporosis and CRN in both women and men (OR = 2.06 and 1.66, respectively). The sensitivity tests revealed results similar to those of the original dataset. In conclusion, osteoporosis is significantly associated with CRN risk in both sexes. In high-risk patients with low BMD, appropriate screening for CRN and vitamin D supplementation are required, regardless of sex.https://www.mdpi.com/2075-4418/14/6/666bone mineral densitycolorectal neoplasmosteoporosissex |
| spellingShingle | Seung Heon Yoo Ji Hyung Nam Dong Jun Oh Geun U Park Sang Hoon Kim Hyoun Woo Kang Jae Hak Kim Yun Jeong Lim Osteoporosis Is Associated with an Increased Risk of Colorectal Neoplasms Regardless of Sex: Nationwide Population-Based Cohort Study Diagnostics bone mineral density colorectal neoplasm osteoporosis sex |
| title | Osteoporosis Is Associated with an Increased Risk of Colorectal Neoplasms Regardless of Sex: Nationwide Population-Based Cohort Study |
| title_full | Osteoporosis Is Associated with an Increased Risk of Colorectal Neoplasms Regardless of Sex: Nationwide Population-Based Cohort Study |
| title_fullStr | Osteoporosis Is Associated with an Increased Risk of Colorectal Neoplasms Regardless of Sex: Nationwide Population-Based Cohort Study |
| title_full_unstemmed | Osteoporosis Is Associated with an Increased Risk of Colorectal Neoplasms Regardless of Sex: Nationwide Population-Based Cohort Study |
| title_short | Osteoporosis Is Associated with an Increased Risk of Colorectal Neoplasms Regardless of Sex: Nationwide Population-Based Cohort Study |
| title_sort | osteoporosis is associated with an increased risk of colorectal neoplasms regardless of sex nationwide population based cohort study |
| topic | bone mineral density colorectal neoplasm osteoporosis sex |
| url | https://www.mdpi.com/2075-4418/14/6/666 |
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