The prognostic value and immunological role of SULF2 in adrenocortical carcinoma
Background: Adrenocortical carcinoma (ACC) represents the rare urological epithelial cancer of urinary tract, which has a large mass and is usually diagnosed at the advanced stage, thus inducing the poor prognosis. As a result, early detection and diagnosis are more important for the prognosis rathe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023008204 |
| _version_ | 1811161725058154496 |
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| author | Jiusong Yan Xiaodu Xie Qinke Li Peihe Liang Junyong Zhang Guangyong Xu |
| author_facet | Jiusong Yan Xiaodu Xie Qinke Li Peihe Liang Junyong Zhang Guangyong Xu |
| author_sort | Jiusong Yan |
| collection | DOAJ |
| description | Background: Adrenocortical carcinoma (ACC) represents the rare urological epithelial cancer of urinary tract, which has a large mass and is usually diagnosed at the advanced stage, thus inducing the poor prognosis. As a result, early detection and diagnosis are more important for the prognosis rather than the treatment of ACC. There is evidence supporting the association of Sulfatase2 (SULF2) with bladder cancer. However, the relationships of SULF2 with the clinical features and immune infiltration of ACC remain unclear. Methods: This work comprehensively investigated the different expression levels of SULF2 within ACC and its prognostic significance through various databases including Gene Expression Profiling Interaction Analysis (GEPIA), Tumor Immune Estimation Resource (TIMER), The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Kaplan–Meier (KM) plotter and UALCAN. Besides, SULF2 levels within different tumor and paraneoplastic tissues were examined based on Human Protein Atlas (HPA) and TIMER. Afterwards, this study identified differentially expressed genes (DEGs) in high-compared with low-SULF2-expression groups. To predict the possible interaction between SULF2 and its targets, a protein-protein interaction (PPI) network was constructed based on relevant data collected in STRING database. Besides, the SULF2 functional annotation was carried out, including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and GSEA. In addition, gene mutation analysis was also performed based on the cBioPortal database. The relation of SULF2 with immune infiltration was analyzed from various aspects by using the resources of various databases including TIMER, TISIDB, and GEPIA, which was first reported in this work. Finally, R package was utilized to plot the receiver operating characteristic (ROC) curves of diagnosis, time-dependent survival, and the association of SULF2 with cancer stage and the nomogram model. Finally, CellMiner dataset was adopted for SULF2 correlation as well as drug sensitivity analysis. Results: Relative to healthy people, SULF2 level markedly elevated within ACC tissues. Besides, SULF2 up-regulation significantly predicted the dismal prognostic outcome, which may be an important prognostic factor. Afterwards, the PPI network was constructed, and the possible link of SULF2 with the corresponding targets was predicted. Besides, up-regulated SULF2 expression was tightly related to immune regulation and tumor-infiltration immune cell (TIICs), including CD8+, CD4+ and mast cells. Finally, SULF2 expression was speculated to help determine the sensitivity of certain drugs. Conclusions: SULF2 may offer a new therapeutic target for ACC patients and become an important potential prognostic biomarker. |
| first_indexed | 2024-04-10T06:20:07Z |
| format | Article |
| id | doaj.art-f8cd84e921f14a31a0a6b3035c4a3b63 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-10T06:20:07Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-f8cd84e921f14a31a0a6b3035c4a3b632023-03-02T05:02:16ZengElsevierHeliyon2405-84402023-02-0192e13613The prognostic value and immunological role of SULF2 in adrenocortical carcinomaJiusong Yan0Xiaodu Xie1Qinke Li2Peihe Liang3Junyong Zhang4Guangyong Xu5Department of Urology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Urology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Gynecology and Obstetrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Urology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Urology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China; Corresponding author.Department of Urology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China; Corresponding author.Background: Adrenocortical carcinoma (ACC) represents the rare urological epithelial cancer of urinary tract, which has a large mass and is usually diagnosed at the advanced stage, thus inducing the poor prognosis. As a result, early detection and diagnosis are more important for the prognosis rather than the treatment of ACC. There is evidence supporting the association of Sulfatase2 (SULF2) with bladder cancer. However, the relationships of SULF2 with the clinical features and immune infiltration of ACC remain unclear. Methods: This work comprehensively investigated the different expression levels of SULF2 within ACC and its prognostic significance through various databases including Gene Expression Profiling Interaction Analysis (GEPIA), Tumor Immune Estimation Resource (TIMER), The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Kaplan–Meier (KM) plotter and UALCAN. Besides, SULF2 levels within different tumor and paraneoplastic tissues were examined based on Human Protein Atlas (HPA) and TIMER. Afterwards, this study identified differentially expressed genes (DEGs) in high-compared with low-SULF2-expression groups. To predict the possible interaction between SULF2 and its targets, a protein-protein interaction (PPI) network was constructed based on relevant data collected in STRING database. Besides, the SULF2 functional annotation was carried out, including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and GSEA. In addition, gene mutation analysis was also performed based on the cBioPortal database. The relation of SULF2 with immune infiltration was analyzed from various aspects by using the resources of various databases including TIMER, TISIDB, and GEPIA, which was first reported in this work. Finally, R package was utilized to plot the receiver operating characteristic (ROC) curves of diagnosis, time-dependent survival, and the association of SULF2 with cancer stage and the nomogram model. Finally, CellMiner dataset was adopted for SULF2 correlation as well as drug sensitivity analysis. Results: Relative to healthy people, SULF2 level markedly elevated within ACC tissues. Besides, SULF2 up-regulation significantly predicted the dismal prognostic outcome, which may be an important prognostic factor. Afterwards, the PPI network was constructed, and the possible link of SULF2 with the corresponding targets was predicted. Besides, up-regulated SULF2 expression was tightly related to immune regulation and tumor-infiltration immune cell (TIICs), including CD8+, CD4+ and mast cells. Finally, SULF2 expression was speculated to help determine the sensitivity of certain drugs. Conclusions: SULF2 may offer a new therapeutic target for ACC patients and become an important potential prognostic biomarker.http://www.sciencedirect.com/science/article/pii/S2405844023008204Adrenocortical carcinoma (ACC)Sulfatase2 (SULF2)PrognosisTumor immune regulation |
| spellingShingle | Jiusong Yan Xiaodu Xie Qinke Li Peihe Liang Junyong Zhang Guangyong Xu The prognostic value and immunological role of SULF2 in adrenocortical carcinoma Heliyon Adrenocortical carcinoma (ACC) Sulfatase2 (SULF2) Prognosis Tumor immune regulation |
| title | The prognostic value and immunological role of SULF2 in adrenocortical carcinoma |
| title_full | The prognostic value and immunological role of SULF2 in adrenocortical carcinoma |
| title_fullStr | The prognostic value and immunological role of SULF2 in adrenocortical carcinoma |
| title_full_unstemmed | The prognostic value and immunological role of SULF2 in adrenocortical carcinoma |
| title_short | The prognostic value and immunological role of SULF2 in adrenocortical carcinoma |
| title_sort | prognostic value and immunological role of sulf2 in adrenocortical carcinoma |
| topic | Adrenocortical carcinoma (ACC) Sulfatase2 (SULF2) Prognosis Tumor immune regulation |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023008204 |
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