The development and function of dendritic cell populations and their regulation by miRNAs
ABSTRACT Dendritic cells (DCs) are important immune cells linking innate and adaptive immune responses. DCs encounter various self and non-self antigens present in the environment and induce different types of antigen specific adaptive immune responses. DCs can be classified into lymphoid tissue-res...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Oxford University Press
2017-03-01
|
| Series: | Protein & Cell |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s13238-017-0398-2 |
| _version_ | 1827841709040467968 |
|---|---|
| author | Haibo Zhou Li Wu |
| author_facet | Haibo Zhou Li Wu |
| author_sort | Haibo Zhou |
| collection | DOAJ |
| description | ABSTRACT Dendritic cells (DCs) are important immune cells linking innate and adaptive immune responses. DCs encounter various self and non-self antigens present in the environment and induce different types of antigen specific adaptive immune responses. DCs can be classified into lymphoid tissue-resident DCs, migratory DCs, non-lymphoid resident DCs, and monocyte derived DCs (moDCs). Recent work has also established that DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. The development of different DC subsets has been found to be regulated by a network of different cytokines and transcriptional factors. Moreover, the response of DC is tightly regulated to maintain the homeostasis of immune system. MicroRNAs (miRNAs) are an important class of cellular regulators that modulate gene expression and thereby influence cell fate and function. In the immune system, miRNAs act at checkpoints during hematopoietic development and cell subset differentiation, they modulate effector cell function, and are implicated in the maintenance of homeostasis. DCs are also regulated by miRNAs. In the past decade, much progress has been made to understand the role of miRNAs in regulating the development and function of DCs. In this review, we summarize the origin and distribution of different mouse DC subsets in both lymphoid and non-lymphoid tissues. The DC subsets identified in human are also described. Recent progress on the function of miRNAs in the development and activation of DCs and their functional relevance to autoimmune diseases are discussed. |
| first_indexed | 2024-03-12T07:56:26Z |
| format | Article |
| id | doaj.art-f8d043b7ebc241a5a659d47c77c57284 |
| institution | Directory Open Access Journal |
| issn | 1674-800X 1674-8018 |
| language | English |
| last_indexed | 2024-03-12T07:56:26Z |
| publishDate | 2017-03-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Protein & Cell |
| spelling | doaj.art-f8d043b7ebc241a5a659d47c77c572842023-09-02T20:12:59ZengOxford University PressProtein & Cell1674-800X1674-80182017-03-018750151310.1007/s13238-017-0398-2The development and function of dendritic cell populations and their regulation by miRNAsHaibo Zhou0Li Wu1Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University School of Medicine, Institute of Immunology Tsinghua UniversityTsinghua-Peking Joint Center for Life Sciences, Tsinghua University School of Medicine, Institute of Immunology Tsinghua UniversityABSTRACT Dendritic cells (DCs) are important immune cells linking innate and adaptive immune responses. DCs encounter various self and non-self antigens present in the environment and induce different types of antigen specific adaptive immune responses. DCs can be classified into lymphoid tissue-resident DCs, migratory DCs, non-lymphoid resident DCs, and monocyte derived DCs (moDCs). Recent work has also established that DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. The development of different DC subsets has been found to be regulated by a network of different cytokines and transcriptional factors. Moreover, the response of DC is tightly regulated to maintain the homeostasis of immune system. MicroRNAs (miRNAs) are an important class of cellular regulators that modulate gene expression and thereby influence cell fate and function. In the immune system, miRNAs act at checkpoints during hematopoietic development and cell subset differentiation, they modulate effector cell function, and are implicated in the maintenance of homeostasis. DCs are also regulated by miRNAs. In the past decade, much progress has been made to understand the role of miRNAs in regulating the development and function of DCs. In this review, we summarize the origin and distribution of different mouse DC subsets in both lymphoid and non-lymphoid tissues. The DC subsets identified in human are also described. Recent progress on the function of miRNAs in the development and activation of DCs and their functional relevance to autoimmune diseases are discussed.http://link.springer.com/article/10.1007/s13238-017-0398-2dendritic cellmirnaactivationdevelopmentautoimmune disease |
| spellingShingle | Haibo Zhou Li Wu The development and function of dendritic cell populations and their regulation by miRNAs Protein & Cell dendritic cell mirna activation development autoimmune disease |
| title | The development and function of dendritic cell populations and their regulation by miRNAs |
| title_full | The development and function of dendritic cell populations and their regulation by miRNAs |
| title_fullStr | The development and function of dendritic cell populations and their regulation by miRNAs |
| title_full_unstemmed | The development and function of dendritic cell populations and their regulation by miRNAs |
| title_short | The development and function of dendritic cell populations and their regulation by miRNAs |
| title_sort | development and function of dendritic cell populations and their regulation by mirnas |
| topic | dendritic cell mirna activation development autoimmune disease |
| url | http://link.springer.com/article/10.1007/s13238-017-0398-2 |
| work_keys_str_mv | AT haibozhou thedevelopmentandfunctionofdendriticcellpopulationsandtheirregulationbymirnas AT liwu thedevelopmentandfunctionofdendriticcellpopulationsandtheirregulationbymirnas AT haibozhou developmentandfunctionofdendriticcellpopulationsandtheirregulationbymirnas AT liwu developmentandfunctionofdendriticcellpopulationsandtheirregulationbymirnas |