Simple and Robust Detection of <i>CYP2D6</i> Gene Deletions and Duplications Using <i>CYP2D8P</i> as Reference

Simple and Robust Detection of <i>CYP2D6</i> Gene Deletions and Duplications Using <i>CYP2D8P</i> as Reference

Genotyping of the <i>CYP2D6</i> gene is the most commonly applied pharmacogenetic test globally. Significant economic interests have led to the development of a plurality of assays, available for almost any genotyping platform or DNA detection chemistry. Of all the genetic variants, copy...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Jens Borggaard Larsen, Steffen Jørgensen
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	MDPI AG 2022-01-01
Cyfres:	Pharmaceuticals
Pynciau:	<i>CYP2D6</i> <i>CYP2D7P</i> <i>CYP2D8P</i> copy number variation CNV genotyping
Mynediad Ar-lein:	https://www.mdpi.com/1424-8247/15/2/166

Eitemau Tebyg

Afro-Latin American Pharmacogenetics of <i>CYP2D6</i>, <i>CYP2C9</i>, and <i>CYP2C19</i> in Dominicans: A Study from the RIBEF-CEIBA Consortium
gan: Mariela Guevara, et al.
Cyhoeddwyd: (2024-10-01)

An Investigational Study on the Role of <i>CYP2D6</i>, <i>CYP3A4</i> and <i>UGT</i>s Genetic Variation on Fesoterodine Pharmacokinetics in Young Healthy Volunteers
gan: Andrea Rodríguez-Lopez, et al.
Cyhoeddwyd: (2024-09-01)

Association of <i>CYP2C19, CYP2D6</i> and <i>CYP3A4</i> Genetic Variants on Primaquine Hemolysis in G6PD-Deficient Patients
gan: Marielle M. Macêdo, et al.
Cyhoeddwyd: (2023-06-01)

<i>CYP2D6</i> Genotype and Pharmacovigilance Impact on Autism Spectrum Disorder: A Naturalistic Study with Extreme Phenotype Analysis
gan: Pura Ballester, et al.
Cyhoeddwyd: (2023-07-01)

Genetic Variation in <i>CYP2D6</i>, <i>UGT1A4</i>, <i>SLC6A2</i> and <i>SLCO1B1</i> Alters the Pharmacokinetics and Safety of Mirabegron
gan: Paula Soria-Chacartegui, et al.
Cyhoeddwyd: (2024-08-01)

Effect of Antibiotic Susceptibility and <i>CYP3A4/5</i> and <i>CYP2C19</i> Genotype on the Outcome of Vonoprazan-Containing <i>Helicobacter pylori</i> Eradication Therapy
gan: Mitsushige Sugimoto, et al.
Cyhoeddwyd: (2020-09-01)

Identification of novel CYP2D7-2D6 hybrids: non-functional and functional variants
gan: Andrea Gaedigk, et al.
Cyhoeddwyd: (2010-10-01)

The Effect of Flavonoid Aglycones on the CYP1A2, CYP2A6, CYP2C8 and CYP2D6 Enzymes Activity
gan: Mirza Bojić, et al.
Cyhoeddwyd: (2019-09-01)

Genetic analysis of the equine orthologues for human CYP2D6: unraveling the complexity of the CYP2D family in horses
gan: Giada Scantamburlo, et al.
Cyhoeddwyd: (2023-10-01)

Involvement of <i>CYP51A</i> and <i>CYP51B</i> in Growth, Reproduction, Pathogenicity, and Sensitivity to Fungicides in <i>Colletotrichum siamense</i>
gan: Shuodan Hu, et al.
Cyhoeddwyd: (2023-01-01)

<i>CYP6B</i> Subtype Expression Fluctuates in the Great Mormon, <i>Papilio memnon</i>, with Changes in the Components of the Host Plants
gan: Miho Nakano, et al.
Cyhoeddwyd: (2025-02-01)

Relevance of <i>CYP2D6</i> Gene Variants in Population Genetic Differentiation
gan: Anita Stojanović Marković, et al.
Cyhoeddwyd: (2022-11-01)

The frequencies of CYP2D6 alleles and their impact on clinical outcomes of adjuvant tamoxifen therapy in Syrian breast cancer patients
gan: Wouroud Ismail Al-khalil, et al.
Cyhoeddwyd: (2022-10-01)

New Variants of the Cytochrome P450 2R1 (<i>CYP2R1</i>) Gene in Individuals with Severe Vitamin D-Activating Enzyme 25(OH)D Deficiency
gan: Martyna Fronczek, et al.
Cyhoeddwyd: (2021-12-01)

Evaluation of the Effect of CYP2D6 Genotypes on Tramadol and <i>O</i>-Desmethyltramadol Pharmacokinetic Profiles in a Korean Population Using Physiologically-Based Pharmacokinetic Modeling
gan: Hyeon-Cheol Jeong, et al.
Cyhoeddwyd: (2019-11-01)

CYP2C9, CYPC19 and CYP2D6 gene profiles and gene susceptibility to drug response and toxicity in Turkish population
gan: Merve Arici, et al.
Cyhoeddwyd: (2017-03-01)

<i>Artemisia annua</i> L. Extracts Irreversibly Inhibit the Activity of CYP2B6 and CYP3A4 Enzymes
gan: Martin Kondža, et al.
Cyhoeddwyd: (2023-01-01)

Cytochrome P450 Monooxygenases <i>CYP6AY3</i> and <i>CYP6CW1</i> Regulate Rice Black-Streaked Dwarf Virus Replication in <i>Laodelphax striatellus</i> (Fallén)
gan: Jian-Hua Zhang, et al.
Cyhoeddwyd: (2021-08-01)

Contribution of CYP2D6 Functional Activity to Oxycodone Efficacy in Pain Management: Genetic Polymorphisms, Phenoconversion, and Tissue-Selective Metabolism
gan: Malavika Deodhar, et al.
Cyhoeddwyd: (2021-09-01)

Analysis of CYP2C9*2, CYP2C19*2, and CYP2D6*4 polymorphisms in patients with type 2 diabetes mellitus
gan: Sabina Semiz, et al.
Cyhoeddwyd: (2010-11-01)

CYP1A2 mRNA Expression Rather than Genetic Variants Indicate Hepatic CYP1A2 Activity
gan: Ferenc Fekete, et al.
Cyhoeddwyd: (2022-02-01)

Identification of Wild-Type <i>CYP321A2</i> and Comparison of Allelochemical-Induced Expression Profiles of <i>CYP321A2</i> with Its Paralog <i>CYP321A1</i> in <i>Helicoverpa zea</i>
gan: Shengyun Li, et al.
Cyhoeddwyd: (2021-01-01)

Pharmacogenetic testing revisited: 5′nuclease real-time polymerase chain reaction test panels for genotyping CYP2D6 and CYP2C19
gan: Larsen JB, et al.
Cyhoeddwyd: (2017-04-01)

The Impact of CYP2D6 Genotyping on Tamoxifen Treatment
gan: Roberta Ferraldeschi, et al.
Cyhoeddwyd: (2010-04-01)

<i>CYP2C19</i> Polymorphisms in Indonesia: Comparison among Ethnicities and the Association with Clinical Outcomes
gan: Muhammad Miftahussurur, et al.
Cyhoeddwyd: (2021-04-01)

Influence of Different Plant Extracts on CYP-Mediated Skatole and Indole Degradation in Pigs
gan: Philipp Marro, et al.
Cyhoeddwyd: (2024-03-01)

Association of CYP2D6 and CYP2C19 metabolizer status with switching and discontinuing antidepressant drugs: an exploratory study
gan: Jurriaan M. J. L. Brouwer, et al.
Cyhoeddwyd: (2024-05-01)

<i>CYP2C19</i> Genetic Variants and Major Depressive Disorder: A Systematic Review
gan: Larissa Sousa Silva Bonasser, et al.
Cyhoeddwyd: (2024-10-01)

Efficacy and safety of antipsychotics in adolescents with an acute psychotic episode in relation to the activity of CYP3A and CYP2D6 isoenzymes
gan: D. V. Ivashchenko, et al.
Cyhoeddwyd: (2020-12-01)

Functional Study and Efficient Catalytic Element Mining of CYP76AHs in <i>Salvia</i> Plants
gan: Zhenyu Zhao, et al.
Cyhoeddwyd: (2023-06-01)

An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study
gan: Blandine De La Gastine, et al.
Cyhoeddwyd: (2022-10-01)

Prevalence of CYP2D6*2, CYP2D6*4, CYP2D6*10, and CYP3A5*3 in Thai breast cancer patients undergoing tamoxifen treatment
gan: Charoenchokthavee W, et al.
Cyhoeddwyd: (2016-08-01)

A Single Site Population Study to Investigate CYP2D6 Phenotype of Patients with Persistent Non-Malignant Pain
gan: Helen Radford, et al.
Cyhoeddwyd: (2019-05-01)

A Cyp51B Mutation Contributes to Azole Resistance in <i>Aspergillus fumigatus</i>
gan: Irene Gonzalez-Jimenez, et al.
Cyhoeddwyd: (2020-11-01)

<i>CYP51</i> Mutations in the <i>Fusarium solani</i> Species Complex: First Clue to Understand the Low Susceptibility to Azoles of the Genus <i>Fusarium</i>
gan: Pierre Vermeulen, et al.
Cyhoeddwyd: (2022-05-01)

YTHDF3 Is Involved in the Diapause Process of Bivoltine <i>Bombyx mori</i> Strains by Regulating the Expression of <i>Cyp307a1</i> and <i>Cyp18a1</i> Genes in the Ecdysone Synthesis Pathway
gan: Yanhua Chen, et al.
Cyhoeddwyd: (2022-08-01)

Identification, Expression and Evolutional Analysis of Two <i>cyp19-like</i> Genes in Amphioxus
gan: Yajun Wang, et al.
Cyhoeddwyd: (2024-04-01)

The Role of Vitamin E in Protecting against Oxidative Stress, Inflammation, and the Neurotoxic Effects of Acute Paracetamol in Pregnant Female Rats
gan: Alaa M. Hammad, et al.
Cyhoeddwyd: (2023-04-01)

Electrochemical Biosensor for Detection of the <i>CYP2C19*2</i> Allele Based on Exonuclease Ⅲ
gan: Siling Chen, et al.
Cyhoeddwyd: (2023-02-01)

Vitamin D status, vitamin D receptor, CYP2R1, and CYP24A1 profiles in children
gan: Anggraini Iriani, et al.
Cyhoeddwyd: (2024-06-01)