Synthetic Biology Approaches to Engineer <i>Saccharomyces cerevisiae</i> towards the Industrial Production of Valuable Polyphenolic Compounds
Polyphenols are plant secondary metabolites with diverse biological and potential therapeutic activities such as antioxidant, anti-inflammatory and anticancer, among others. However, their extraction from the native plants is not enough to satisfy the increasing demand for this type of compounds. Th...
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MDPI AG
2020-05-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/10/5/56 |
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| author | João Rainha Daniela Gomes Lígia R. Rodrigues Joana L. Rodrigues |
| author_facet | João Rainha Daniela Gomes Lígia R. Rodrigues Joana L. Rodrigues |
| author_sort | João Rainha |
| collection | DOAJ |
| description | Polyphenols are plant secondary metabolites with diverse biological and potential therapeutic activities such as antioxidant, anti-inflammatory and anticancer, among others. However, their extraction from the native plants is not enough to satisfy the increasing demand for this type of compounds. The development of microbial cell factories to effectively produce polyphenols may represent the most attractive solution to overcome this limitation and produce high amounts of these bioactive molecules. With the advances in the synthetic biology field, the development of efficient microbial cell factories has become easier, largely due to the development of the molecular biology techniques and by the identification of novel isoenzymes in plants or simpler organisms to construct the heterologous pathways. Furthermore, efforts have been made to make the process more profitable through improvements in the host chassis. In this review, advances in the production of polyphenols by genetically engineered <i>Saccharomyces cerevisiae</i> as well as by synthetic biology and metabolic engineering approaches to improve the production of these compounds at industrial settings are discussed. |
| first_indexed | 2024-03-10T20:06:04Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T20:06:04Z |
| publishDate | 2020-05-01 |
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| spelling | doaj.art-f8d197776cd24909821454c6af35f9af2023-11-19T23:18:51ZengMDPI AGLife2075-17292020-05-011055610.3390/life10050056Synthetic Biology Approaches to Engineer <i>Saccharomyces cerevisiae</i> towards the Industrial Production of Valuable Polyphenolic CompoundsJoão Rainha0Daniela Gomes1Lígia R. Rodrigues2Joana L. Rodrigues3Centre of Biological Engineering, University of Minho, 4710-057 Braga, PortugalCentre of Biological Engineering, University of Minho, 4710-057 Braga, PortugalCentre of Biological Engineering, University of Minho, 4710-057 Braga, PortugalCentre of Biological Engineering, University of Minho, 4710-057 Braga, PortugalPolyphenols are plant secondary metabolites with diverse biological and potential therapeutic activities such as antioxidant, anti-inflammatory and anticancer, among others. However, their extraction from the native plants is not enough to satisfy the increasing demand for this type of compounds. The development of microbial cell factories to effectively produce polyphenols may represent the most attractive solution to overcome this limitation and produce high amounts of these bioactive molecules. With the advances in the synthetic biology field, the development of efficient microbial cell factories has become easier, largely due to the development of the molecular biology techniques and by the identification of novel isoenzymes in plants or simpler organisms to construct the heterologous pathways. Furthermore, efforts have been made to make the process more profitable through improvements in the host chassis. In this review, advances in the production of polyphenols by genetically engineered <i>Saccharomyces cerevisiae</i> as well as by synthetic biology and metabolic engineering approaches to improve the production of these compounds at industrial settings are discussed.https://www.mdpi.com/2075-1729/10/5/56polyphenols biosynthesissynthetic biology<i>Saccharomyces cerevisiae</i>metabolic engineeringheterologous production |
| spellingShingle | João Rainha Daniela Gomes Lígia R. Rodrigues Joana L. Rodrigues Synthetic Biology Approaches to Engineer <i>Saccharomyces cerevisiae</i> towards the Industrial Production of Valuable Polyphenolic Compounds Life polyphenols biosynthesis synthetic biology <i>Saccharomyces cerevisiae</i> metabolic engineering heterologous production |
| title | Synthetic Biology Approaches to Engineer <i>Saccharomyces cerevisiae</i> towards the Industrial Production of Valuable Polyphenolic Compounds |
| title_full | Synthetic Biology Approaches to Engineer <i>Saccharomyces cerevisiae</i> towards the Industrial Production of Valuable Polyphenolic Compounds |
| title_fullStr | Synthetic Biology Approaches to Engineer <i>Saccharomyces cerevisiae</i> towards the Industrial Production of Valuable Polyphenolic Compounds |
| title_full_unstemmed | Synthetic Biology Approaches to Engineer <i>Saccharomyces cerevisiae</i> towards the Industrial Production of Valuable Polyphenolic Compounds |
| title_short | Synthetic Biology Approaches to Engineer <i>Saccharomyces cerevisiae</i> towards the Industrial Production of Valuable Polyphenolic Compounds |
| title_sort | synthetic biology approaches to engineer i saccharomyces cerevisiae i towards the industrial production of valuable polyphenolic compounds |
| topic | polyphenols biosynthesis synthetic biology <i>Saccharomyces cerevisiae</i> metabolic engineering heterologous production |
| url | https://www.mdpi.com/2075-1729/10/5/56 |
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