Light-Driven CO2 Reduction by Co-Cytochrome b562
The current trend in atmospheric carbon dioxide concentrations is causing increasing concerns for its environmental impacts, and spurring the developments of sustainable methods to reduce CO2 to usable molecules. We report the light-driven CO2 reduction in water in mild conditions by artificial prot...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.609654/full |
| _version_ | 1818456572264710144 |
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| author | Rafael Alcala-Torano Nicholas Halloran Noah Gwerder Dayn J. Sommer Giovanna Ghirlanda |
| author_facet | Rafael Alcala-Torano Nicholas Halloran Noah Gwerder Dayn J. Sommer Giovanna Ghirlanda |
| author_sort | Rafael Alcala-Torano |
| collection | DOAJ |
| description | The current trend in atmospheric carbon dioxide concentrations is causing increasing concerns for its environmental impacts, and spurring the developments of sustainable methods to reduce CO2 to usable molecules. We report the light-driven CO2 reduction in water in mild conditions by artificial protein catalysts based on cytochrome b562 and incorporating cobalt protoporphyrin IX as cofactor. Incorporation into the protein scaffolds enhances the intrinsic reactivity of the cobalt porphyrin toward proton reduction and CO generation. Mutations around the binding site modulate the activity of the enzyme, pointing to the possibility of further improving catalytic activity through rational design or directed evolution. |
| first_indexed | 2024-12-14T22:28:48Z |
| format | Article |
| id | doaj.art-f8d1e1a72f2f4f89aacaae6f29a0552b |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-14T22:28:48Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-f8d1e1a72f2f4f89aacaae6f29a0552b2022-12-21T22:45:18ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-04-01810.3389/fmolb.2021.609654609654Light-Driven CO2 Reduction by Co-Cytochrome b562Rafael Alcala-ToranoNicholas HalloranNoah GwerderDayn J. SommerGiovanna GhirlandaThe current trend in atmospheric carbon dioxide concentrations is causing increasing concerns for its environmental impacts, and spurring the developments of sustainable methods to reduce CO2 to usable molecules. We report the light-driven CO2 reduction in water in mild conditions by artificial protein catalysts based on cytochrome b562 and incorporating cobalt protoporphyrin IX as cofactor. Incorporation into the protein scaffolds enhances the intrinsic reactivity of the cobalt porphyrin toward proton reduction and CO generation. Mutations around the binding site modulate the activity of the enzyme, pointing to the possibility of further improving catalytic activity through rational design or directed evolution.https://www.frontiersin.org/articles/10.3389/fmolb.2021.609654/fullcobalt porphyrinCarbon fixationCO2 reductioncatalysisprotein designproton reduction |
| spellingShingle | Rafael Alcala-Torano Nicholas Halloran Noah Gwerder Dayn J. Sommer Giovanna Ghirlanda Light-Driven CO2 Reduction by Co-Cytochrome b562 Frontiers in Molecular Biosciences cobalt porphyrin Carbon fixation CO2 reduction catalysis protein design proton reduction |
| title | Light-Driven CO2 Reduction by Co-Cytochrome b562 |
| title_full | Light-Driven CO2 Reduction by Co-Cytochrome b562 |
| title_fullStr | Light-Driven CO2 Reduction by Co-Cytochrome b562 |
| title_full_unstemmed | Light-Driven CO2 Reduction by Co-Cytochrome b562 |
| title_short | Light-Driven CO2 Reduction by Co-Cytochrome b562 |
| title_sort | light driven co2 reduction by co cytochrome b562 |
| topic | cobalt porphyrin Carbon fixation CO2 reduction catalysis protein design proton reduction |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.609654/full |
| work_keys_str_mv | AT rafaelalcalatorano lightdrivenco2reductionbycocytochromeb562 AT nicholashalloran lightdrivenco2reductionbycocytochromeb562 AT noahgwerder lightdrivenco2reductionbycocytochromeb562 AT daynjsommer lightdrivenco2reductionbycocytochromeb562 AT giovannaghirlanda lightdrivenco2reductionbycocytochromeb562 |