Macrophages take up VLDL-sized emulsion particles through caveolae-mediated endocytosis and excrete part of the internalized triglycerides as fatty acids.

Macrophages take up VLDL-sized emulsion particles through caveolae-mediated endocytosis and excrete part of the internalized triglycerides as fatty acids.

Triglycerides are carried in the bloodstream as part of very low-density lipoproteins (VLDLs) and chylomicrons, which represent the triglyceride-rich lipoproteins. Triglyceride-rich lipoproteins and their remnants contribute to atherosclerosis, possibly by carrying remnant cholesterol and/or by exer...

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Bibliographic Details
Main Authors: Lei Deng, Frank Vrieling, Rinke Stienstra, Guido J Hooiveld, Anouk L Feitsma, Sander Kersten
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-08-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001516

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