Butyrylcholinesterase genetic variability in Guarani Amerindians from the Brazilian state of Mato Grosso do Sul
Human butyrylcholinesterase (BChE; EC 3.1.1.8) is a polymorphic enzyme coded by the BCHE gene (3q26.1-q26.2) while the CHE2 gene (2q33-q35) determines a still not characterized substance that forms a complex with BChE (C5), being the CHE2 C5+ and CHE2 C5- phenotypes detected in electrophoresis. The...
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Sociedade Brasileira de Genética
2006-01-01
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| Series: | Genetics and Molecular Biology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000100002 |
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| author | Lupe Furtado Ricardo L. R. Souza Luiza T. Tsuneto Maria Luiza Petzl-Erler Eleidi A. Chautard-Freire-Maia |
| author_facet | Lupe Furtado Ricardo L. R. Souza Luiza T. Tsuneto Maria Luiza Petzl-Erler Eleidi A. Chautard-Freire-Maia |
| author_sort | Lupe Furtado |
| collection | DOAJ |
| description | Human butyrylcholinesterase (BChE; EC 3.1.1.8) is a polymorphic enzyme coded by the BCHE gene (3q26.1-q26.2) while the CHE2 gene (2q33-q35) determines a still not characterized substance that forms a complex with BChE (C5), being the CHE2 C5+ and CHE2 C5- phenotypes detected in electrophoresis. The present study investigated BCHE and CHE2 variability and the BChE activity of Brazilian Guarani Amerindians from the Kaiowá and Ñandeva sub-groups living in several indigenous territories in the Brazilian state of Mato Grosso do Sul. The frequency of the BCHE exon 2 D70G (A) allele was 0.60% ± 0.35% while that of the BCHE exon 2 G390V (F-2) allele, never before screened in Amerindians, was 8.82% ± 1.35%. This is the first time that the BCHE gene exon 4 A539T (K) allele has been surveyed in Brazilian Amerindians where it was found at a frequency of 3.69% ± 0.85%, similar to that found in Chilean Mapuche Amerindians. The BCHE gene variability seen in this survey differs from that of non-isolated populations in respect to both A539T and G390V allele frequency. The CHE2 C5+ phenotype frequency was 14.40% ± 2.22% and falls within the range of that found for other Brazilian Amerindian samples. |
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| format | Article |
| id | doaj.art-f8d4d2fe1e7d4c72a7db0d3ea0677ffb |
| institution | Directory Open Access Journal |
| issn | 1415-4757 1678-4685 |
| language | English |
| last_indexed | 2024-12-20T19:33:33Z |
| publishDate | 2006-01-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-f8d4d2fe1e7d4c72a7db0d3ea0677ffb2022-12-21T19:28:44ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-46852006-01-0129181310.1590/S1415-47572006000100002Butyrylcholinesterase genetic variability in Guarani Amerindians from the Brazilian state of Mato Grosso do SulLupe FurtadoRicardo L. R. SouzaLuiza T. TsunetoMaria Luiza Petzl-ErlerEleidi A. Chautard-Freire-MaiaHuman butyrylcholinesterase (BChE; EC 3.1.1.8) is a polymorphic enzyme coded by the BCHE gene (3q26.1-q26.2) while the CHE2 gene (2q33-q35) determines a still not characterized substance that forms a complex with BChE (C5), being the CHE2 C5+ and CHE2 C5- phenotypes detected in electrophoresis. The present study investigated BCHE and CHE2 variability and the BChE activity of Brazilian Guarani Amerindians from the Kaiowá and Ñandeva sub-groups living in several indigenous territories in the Brazilian state of Mato Grosso do Sul. The frequency of the BCHE exon 2 D70G (A) allele was 0.60% ± 0.35% while that of the BCHE exon 2 G390V (F-2) allele, never before screened in Amerindians, was 8.82% ± 1.35%. This is the first time that the BCHE gene exon 4 A539T (K) allele has been surveyed in Brazilian Amerindians where it was found at a frequency of 3.69% ± 0.85%, similar to that found in Chilean Mapuche Amerindians. The BCHE gene variability seen in this survey differs from that of non-isolated populations in respect to both A539T and G390V allele frequency. The CHE2 C5+ phenotype frequency was 14.40% ± 2.22% and falls within the range of that found for other Brazilian Amerindian samples.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000100002BCHE geneA alleleF-2 and K allelesGuarani-KaiowáGuarani-Ñandeva |
| spellingShingle | Lupe Furtado Ricardo L. R. Souza Luiza T. Tsuneto Maria Luiza Petzl-Erler Eleidi A. Chautard-Freire-Maia Butyrylcholinesterase genetic variability in Guarani Amerindians from the Brazilian state of Mato Grosso do Sul Genetics and Molecular Biology BCHE gene A allele F-2 and K alleles Guarani-Kaiowá Guarani-Ñandeva |
| title | Butyrylcholinesterase genetic variability in Guarani Amerindians from the Brazilian state of Mato Grosso do Sul |
| title_full | Butyrylcholinesterase genetic variability in Guarani Amerindians from the Brazilian state of Mato Grosso do Sul |
| title_fullStr | Butyrylcholinesterase genetic variability in Guarani Amerindians from the Brazilian state of Mato Grosso do Sul |
| title_full_unstemmed | Butyrylcholinesterase genetic variability in Guarani Amerindians from the Brazilian state of Mato Grosso do Sul |
| title_short | Butyrylcholinesterase genetic variability in Guarani Amerindians from the Brazilian state of Mato Grosso do Sul |
| title_sort | butyrylcholinesterase genetic variability in guarani amerindians from the brazilian state of mato grosso do sul |
| topic | BCHE gene A allele F-2 and K alleles Guarani-Kaiowá Guarani-Ñandeva |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000100002 |
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