Efficacy of the oral neurokinin-1 receptor antagonist aprepitant administered with ondansetron for the prevention of postoperative nausea and vomiting
Background5-HT3 receptor antagonist, dexamethasone and droperidol were used for the prevention of postoperative nausea and vomiting (PONV). Recently, neurokinin-1 (NK1) antagonist has been used for PONV. We evaluated the effect of oral aprepitant premedication in addition to ondansetron.MethodsA tot...
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Korean Society of Anesthesiologists
2013-03-01
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| Series: | Korean Journal of Anesthesiology |
| Subjects: | |
| Online Access: | http://ekja.org/upload/pdf/kjae-64-212.pdf |
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| author | Chae Seong Lim Young-Kwon Ko Yoon-Hee Kim Sang-Il Park Jae-Kook Kim Myoung-Joong Kim Hyun-Joong Kim |
| author_facet | Chae Seong Lim Young-Kwon Ko Yoon-Hee Kim Sang-Il Park Jae-Kook Kim Myoung-Joong Kim Hyun-Joong Kim |
| author_sort | Chae Seong Lim |
| collection | DOAJ |
| description | Background5-HT3 receptor antagonist, dexamethasone and droperidol were used for the prevention of postoperative nausea and vomiting (PONV). Recently, neurokinin-1 (NK1) antagonist has been used for PONV. We evaluated the effect of oral aprepitant premedication in addition to ondansetron.MethodsA total 90 patients scheduled for elective rhinolaryngological surgery were allocated to three groups (Control, Ap80, Ap125), each of 30 at random. Ondansetron 4 mg was injected intravenously to all patients just before the end of surgery. On the morning of surgery, 80 mg and 125 mg aprepitant were additionally administered into the Ap80 group and Ap125 group, respectively. The rhodes index of nausea, vomiting and retching (RINVR) was checked at 6 hr and 24 hr after surgery.ResultsTwelve patients who used steroids unexpectedly were excluded. Finally 78 patients (control : Ap80 : Ap125 = 24 : 28 : 26) were enrolled. Overall PONV occurrence rate of Ap125 group (1/26, 3.9%) was lower (P = 0.015) than the control group (7/24, 29.2%) at 6 hr after surgery. The nausea distress score of Ap125 group (0.04 ± 0.20) was lower (P = 0.032) than the control group (0.67 ± 1.24) at 6 hr after surgery. No evident side effect of aprepitant was observed.ConclusionsOral aprepitant 125 mg can be used as combination therapy for the prevention of PONV. |
| first_indexed | 2024-12-13T02:41:12Z |
| format | Article |
| id | doaj.art-f8d690d337cb4f8d90e211fcd1545f77 |
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| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-13T02:41:12Z |
| publishDate | 2013-03-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-f8d690d337cb4f8d90e211fcd1545f772022-12-22T00:02:17ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632013-03-0164321221710.4097/kjae.2013.64.3.2127522Efficacy of the oral neurokinin-1 receptor antagonist aprepitant administered with ondansetron for the prevention of postoperative nausea and vomitingChae Seong Lim0Young-Kwon Ko1Yoon-Hee Kim2Sang-Il Park3Jae-Kook Kim4Myoung-Joong Kim5Hyun-Joong Kim6Department of Anesthesiology and Pain Medicine, College of Medicine, Chungnam National University, Daejeon, Korea.Department of Anesthesiology and Pain Medicine, College of Medicine, Chungnam National University, Daejeon, Korea.Department of Anesthesiology and Pain Medicine, College of Medicine, Chungnam National University, Daejeon, Korea.Department of Anesthesiology and Pain Medicine, College of Medicine, Chungnam National University, Daejeon, Korea.Department of Anesthesiology and Pain Medicine, College of Medicine, Chungnam National University, Daejeon, Korea.Department of Anesthesiology and Pain Medicine, College of Medicine, Chungnam National University, Daejeon, Korea.Department of Anesthesiology and Pain Medicine, College of Medicine, Chungnam National University, Daejeon, Korea.Background5-HT3 receptor antagonist, dexamethasone and droperidol were used for the prevention of postoperative nausea and vomiting (PONV). Recently, neurokinin-1 (NK1) antagonist has been used for PONV. We evaluated the effect of oral aprepitant premedication in addition to ondansetron.MethodsA total 90 patients scheduled for elective rhinolaryngological surgery were allocated to three groups (Control, Ap80, Ap125), each of 30 at random. Ondansetron 4 mg was injected intravenously to all patients just before the end of surgery. On the morning of surgery, 80 mg and 125 mg aprepitant were additionally administered into the Ap80 group and Ap125 group, respectively. The rhodes index of nausea, vomiting and retching (RINVR) was checked at 6 hr and 24 hr after surgery.ResultsTwelve patients who used steroids unexpectedly were excluded. Finally 78 patients (control : Ap80 : Ap125 = 24 : 28 : 26) were enrolled. Overall PONV occurrence rate of Ap125 group (1/26, 3.9%) was lower (P = 0.015) than the control group (7/24, 29.2%) at 6 hr after surgery. The nausea distress score of Ap125 group (0.04 ± 0.20) was lower (P = 0.032) than the control group (0.67 ± 1.24) at 6 hr after surgery. No evident side effect of aprepitant was observed.ConclusionsOral aprepitant 125 mg can be used as combination therapy for the prevention of PONV.http://ekja.org/upload/pdf/kjae-64-212.pdfaprepitantondansetronponv |
| spellingShingle | Chae Seong Lim Young-Kwon Ko Yoon-Hee Kim Sang-Il Park Jae-Kook Kim Myoung-Joong Kim Hyun-Joong Kim Efficacy of the oral neurokinin-1 receptor antagonist aprepitant administered with ondansetron for the prevention of postoperative nausea and vomiting Korean Journal of Anesthesiology aprepitant ondansetron ponv |
| title | Efficacy of the oral neurokinin-1 receptor antagonist aprepitant administered with ondansetron for the prevention of postoperative nausea and vomiting |
| title_full | Efficacy of the oral neurokinin-1 receptor antagonist aprepitant administered with ondansetron for the prevention of postoperative nausea and vomiting |
| title_fullStr | Efficacy of the oral neurokinin-1 receptor antagonist aprepitant administered with ondansetron for the prevention of postoperative nausea and vomiting |
| title_full_unstemmed | Efficacy of the oral neurokinin-1 receptor antagonist aprepitant administered with ondansetron for the prevention of postoperative nausea and vomiting |
| title_short | Efficacy of the oral neurokinin-1 receptor antagonist aprepitant administered with ondansetron for the prevention of postoperative nausea and vomiting |
| title_sort | efficacy of the oral neurokinin 1 receptor antagonist aprepitant administered with ondansetron for the prevention of postoperative nausea and vomiting |
| topic | aprepitant ondansetron ponv |
| url | http://ekja.org/upload/pdf/kjae-64-212.pdf |
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