Síntese e caracterização de um novo complexo de platina (IV) a partir de seu análogo de platina (II) utilizando iodo molecular como agente oxidante: uma rota sintética interessante para obtenção de novos complexos de platina Synthesis and characterization of a novel platinum (IV) complex from its platinum (II) analogue using molecular iodine as an oxidizing agent: an interesting synthetic route for the preparation of new platinum complexes
<abstract language="eng">In an attempt to reduce toxicity and widen the spectrum of activity of cisplatin and its analogues, much attention has been focused on designing new platinum complexes. This work reports the synthesis and characterization of novel compounds of the platinum (I...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2007-02-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000100013 |
| _version_ | 1818066104588697600 |
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| author | Wendell Guerra Heveline Silva Mauro Vieira de Almeida Ana Paula Soares Fontes |
| author_facet | Wendell Guerra Heveline Silva Mauro Vieira de Almeida Ana Paula Soares Fontes |
| author_sort | Wendell Guerra |
| collection | DOAJ |
| description | <abstract language="eng">In an attempt to reduce toxicity and widen the spectrum of activity of cisplatin and its analogues, much attention has been focused on designing new platinum complexes. This work reports the synthesis and characterization of novel compounds of the platinum (II) and platinum (IV) containing 2-furoic hydrazide acid and iodide as ligands. Although the prepared compounds do not present the classical structure of biologically active platinum analogues, they could be potentially active or useful as precursors to prepare antitumor platinum complexes. The reported compounds were characterized by ¹H NMR, 13C NMR, 195Pt NMR, IR and elemental analyses. |
| first_indexed | 2024-12-10T15:02:29Z |
| format | Article |
| id | doaj.art-f8d731fb12ce48c68eef9e5d61c4302c |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-10T15:02:29Z |
| publishDate | 2007-02-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-f8d731fb12ce48c68eef9e5d61c4302c2022-12-22T01:44:08ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642007-02-01301565810.1590/S0100-40422007000100013Síntese e caracterização de um novo complexo de platina (IV) a partir de seu análogo de platina (II) utilizando iodo molecular como agente oxidante: uma rota sintética interessante para obtenção de novos complexos de platina Synthesis and characterization of a novel platinum (IV) complex from its platinum (II) analogue using molecular iodine as an oxidizing agent: an interesting synthetic route for the preparation of new platinum complexesWendell GuerraHeveline SilvaMauro Vieira de AlmeidaAna Paula Soares Fontes<abstract language="eng">In an attempt to reduce toxicity and widen the spectrum of activity of cisplatin and its analogues, much attention has been focused on designing new platinum complexes. This work reports the synthesis and characterization of novel compounds of the platinum (II) and platinum (IV) containing 2-furoic hydrazide acid and iodide as ligands. Although the prepared compounds do not present the classical structure of biologically active platinum analogues, they could be potentially active or useful as precursors to prepare antitumor platinum complexes. The reported compounds were characterized by ¹H NMR, 13C NMR, 195Pt NMR, IR and elemental analyses.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000100013platinum complexeshydrazidesiodo ligands |
| spellingShingle | Wendell Guerra Heveline Silva Mauro Vieira de Almeida Ana Paula Soares Fontes Síntese e caracterização de um novo complexo de platina (IV) a partir de seu análogo de platina (II) utilizando iodo molecular como agente oxidante: uma rota sintética interessante para obtenção de novos complexos de platina Synthesis and characterization of a novel platinum (IV) complex from its platinum (II) analogue using molecular iodine as an oxidizing agent: an interesting synthetic route for the preparation of new platinum complexes Química Nova platinum complexes hydrazides iodo ligands |
| title | Síntese e caracterização de um novo complexo de platina (IV) a partir de seu análogo de platina (II) utilizando iodo molecular como agente oxidante: uma rota sintética interessante para obtenção de novos complexos de platina Synthesis and characterization of a novel platinum (IV) complex from its platinum (II) analogue using molecular iodine as an oxidizing agent: an interesting synthetic route for the preparation of new platinum complexes |
| title_full | Síntese e caracterização de um novo complexo de platina (IV) a partir de seu análogo de platina (II) utilizando iodo molecular como agente oxidante: uma rota sintética interessante para obtenção de novos complexos de platina Synthesis and characterization of a novel platinum (IV) complex from its platinum (II) analogue using molecular iodine as an oxidizing agent: an interesting synthetic route for the preparation of new platinum complexes |
| title_fullStr | Síntese e caracterização de um novo complexo de platina (IV) a partir de seu análogo de platina (II) utilizando iodo molecular como agente oxidante: uma rota sintética interessante para obtenção de novos complexos de platina Synthesis and characterization of a novel platinum (IV) complex from its platinum (II) analogue using molecular iodine as an oxidizing agent: an interesting synthetic route for the preparation of new platinum complexes |
| title_full_unstemmed | Síntese e caracterização de um novo complexo de platina (IV) a partir de seu análogo de platina (II) utilizando iodo molecular como agente oxidante: uma rota sintética interessante para obtenção de novos complexos de platina Synthesis and characterization of a novel platinum (IV) complex from its platinum (II) analogue using molecular iodine as an oxidizing agent: an interesting synthetic route for the preparation of new platinum complexes |
| title_short | Síntese e caracterização de um novo complexo de platina (IV) a partir de seu análogo de platina (II) utilizando iodo molecular como agente oxidante: uma rota sintética interessante para obtenção de novos complexos de platina Synthesis and characterization of a novel platinum (IV) complex from its platinum (II) analogue using molecular iodine as an oxidizing agent: an interesting synthetic route for the preparation of new platinum complexes |
| title_sort | sintese e caracterizacao de um novo complexo de platina iv a partir de seu analogo de platina ii utilizando iodo molecular como agente oxidante uma rota sintetica interessante para obtencao de novos complexos de platina synthesis and characterization of a novel platinum iv complex from its platinum ii analogue using molecular iodine as an oxidizing agent an interesting synthetic route for the preparation of new platinum complexes |
| topic | platinum complexes hydrazides iodo ligands |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000100013 |
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