Natural Products and Their Derivatives against Human Herpesvirus Infection
Herpesviruses establish long-term latent infection for the life of the host and are known to cause numerous diseases. The prevalence of viral infection is significantly increased and causes a worldwide challenge in terms of health issues due to drug resistance. Prolonged treatment with conventional...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/20/6290 |
| _version_ | 1797513727256297472 |
|---|---|
| author | Chattarin Ruchawapol Man Yuan Si-Min Wang Wen-Wei Fu Hong-Xi Xu |
| author_facet | Chattarin Ruchawapol Man Yuan Si-Min Wang Wen-Wei Fu Hong-Xi Xu |
| author_sort | Chattarin Ruchawapol |
| collection | DOAJ |
| description | Herpesviruses establish long-term latent infection for the life of the host and are known to cause numerous diseases. The prevalence of viral infection is significantly increased and causes a worldwide challenge in terms of health issues due to drug resistance. Prolonged treatment with conventional antiviral drugs is more likely to develop drug-resistant strains due to mutations of thymidine nucleoside kinase or DNA polymerase. Hence, the development of alternative treatments is clearly required. Natural products and their derivatives have played a significant role in treating herpesvirus infection rather than nucleoside analogs in drug-resistant strains with minimal undesirable effects and different mechanisms of action. Numerous plants, animals, fungi, and bacteria-derived compounds have been proved to be efficient and safe for treating human herpesvirus infection. This review covers the natural antiherpetic agents with the chemical structural class of alkaloids, flavonoids, terpenoids, polyphenols, anthraquinones, anthracyclines, and miscellaneous compounds, and their antiviral mechanisms have been summarized. This review would be helpful to get a better grasp of anti-herpesvirus activity of natural products and their derivatives, and to evaluate the feasibility of natural compounds as an alternative therapy against herpesvirus infections in humans. |
| first_indexed | 2024-03-10T06:20:39Z |
| format | Article |
| id | doaj.art-f8d7f9d2f2ab452cbb3c99f48bd2adf4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T06:20:39Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f8d7f9d2f2ab452cbb3c99f48bd2adf42023-11-22T19:21:01ZengMDPI AGMolecules1420-30492021-10-012620629010.3390/molecules26206290Natural Products and Their Derivatives against Human Herpesvirus InfectionChattarin Ruchawapol0Man Yuan1Si-Min Wang2Wen-Wei Fu3Hong-Xi Xu4School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Cai Lun Lu 1200, Shanghai 201203, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Cai Lun Lu 1200, Shanghai 201203, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Cai Lun Lu 1200, Shanghai 201203, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Cai Lun Lu 1200, Shanghai 201203, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Cai Lun Lu 1200, Shanghai 201203, ChinaHerpesviruses establish long-term latent infection for the life of the host and are known to cause numerous diseases. The prevalence of viral infection is significantly increased and causes a worldwide challenge in terms of health issues due to drug resistance. Prolonged treatment with conventional antiviral drugs is more likely to develop drug-resistant strains due to mutations of thymidine nucleoside kinase or DNA polymerase. Hence, the development of alternative treatments is clearly required. Natural products and their derivatives have played a significant role in treating herpesvirus infection rather than nucleoside analogs in drug-resistant strains with minimal undesirable effects and different mechanisms of action. Numerous plants, animals, fungi, and bacteria-derived compounds have been proved to be efficient and safe for treating human herpesvirus infection. This review covers the natural antiherpetic agents with the chemical structural class of alkaloids, flavonoids, terpenoids, polyphenols, anthraquinones, anthracyclines, and miscellaneous compounds, and their antiviral mechanisms have been summarized. This review would be helpful to get a better grasp of anti-herpesvirus activity of natural products and their derivatives, and to evaluate the feasibility of natural compounds as an alternative therapy against herpesvirus infections in humans.https://www.mdpi.com/1420-3049/26/20/6290herpesvirusesalkaloidsflavonoidsterpenoidspolyphenolsanthraquinones |
| spellingShingle | Chattarin Ruchawapol Man Yuan Si-Min Wang Wen-Wei Fu Hong-Xi Xu Natural Products and Their Derivatives against Human Herpesvirus Infection Molecules herpesviruses alkaloids flavonoids terpenoids polyphenols anthraquinones |
| title | Natural Products and Their Derivatives against Human Herpesvirus Infection |
| title_full | Natural Products and Their Derivatives against Human Herpesvirus Infection |
| title_fullStr | Natural Products and Their Derivatives against Human Herpesvirus Infection |
| title_full_unstemmed | Natural Products and Their Derivatives against Human Herpesvirus Infection |
| title_short | Natural Products and Their Derivatives against Human Herpesvirus Infection |
| title_sort | natural products and their derivatives against human herpesvirus infection |
| topic | herpesviruses alkaloids flavonoids terpenoids polyphenols anthraquinones |
| url | https://www.mdpi.com/1420-3049/26/20/6290 |
| work_keys_str_mv | AT chattarinruchawapol naturalproductsandtheirderivativesagainsthumanherpesvirusinfection AT manyuan naturalproductsandtheirderivativesagainsthumanherpesvirusinfection AT siminwang naturalproductsandtheirderivativesagainsthumanherpesvirusinfection AT wenweifu naturalproductsandtheirderivativesagainsthumanherpesvirusinfection AT hongxixu naturalproductsandtheirderivativesagainsthumanherpesvirusinfection |