The Potency of Platelet-Rich Plasma for Chronic Low Back Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trial
Low back pain is one of the leading causes of disability in the world. Regenerative medicine can be one of the novel treatment breakthroughs in patients with low back pain, yet its use is still debatable. We performed a systematic evaluation and meta-analysis to determine the efficacy of platelet-ri...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korean Spine Society
2023-08-01
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| Series: | Asian Spine Journal |
| Subjects: | |
| Online Access: | http://www.asianspinejournal.org/upload/pdf/asj-2022-0209.pdf |
| _version_ | 1797738224629579776 |
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| author | Leonard Christianto Singjie Samuel Andi Kusuma Ifran Saleh Erica Kholinne |
| author_facet | Leonard Christianto Singjie Samuel Andi Kusuma Ifran Saleh Erica Kholinne |
| author_sort | Leonard Christianto Singjie |
| collection | DOAJ |
| description | Low back pain is one of the leading causes of disability in the world. Regenerative medicine can be one of the novel treatment breakthroughs in patients with low back pain, yet its use is still debatable. We performed a systematic evaluation and meta-analysis to determine the efficacy of platelet-rich plasma (PRP) treatment for patients with chronic low back pain. Comprehensive database searches were performed in four databases. This study was conducted and reported based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses Guideline and registered to PROSPERO. We included and examined randomized controlled trials that looked into research employing PRP for patients with chronic low back pain. Outcomes of interest include clinical enhancement of pain, which is demonstrated in pain scores. Three studies were included comprising 138 patients with chronic low back pain. After 1, 3, and 6 months after injection, there was a substantial reduction in the pain score difference between the PRP and control groups, demonstrating PRP’s superiority over the control group in the treatment of chronic low back pain. PRP injection significantly enhances chronic low back pain in the first, third, and sixth months after injection compared to controls. |
| first_indexed | 2024-03-12T13:39:48Z |
| format | Article |
| id | doaj.art-f8d834be3834415c97e932251843222c |
| institution | Directory Open Access Journal |
| issn | 1976-1902 1976-7846 |
| language | English |
| last_indexed | 2024-03-12T13:39:48Z |
| publishDate | 2023-08-01 |
| publisher | Korean Spine Society |
| record_format | Article |
| series | Asian Spine Journal |
| spelling | doaj.art-f8d834be3834415c97e932251843222c2023-08-23T23:49:26ZengKorean Spine SocietyAsian Spine Journal1976-19021976-78462023-08-0117478278910.31616/asj.2022.02091523The Potency of Platelet-Rich Plasma for Chronic Low Back Pain: A Systematic Review and Meta-analysis of Randomized Controlled TrialLeonard Christianto Singjie0Samuel Andi Kusuma1Ifran Saleh2Erica Kholinne3 Bone and Joint Center, St. Carolus Hospital, Jakarta, Indonesia Atma Jaya Hospital, Jakarta, Indonesia Bone and Joint Center, St. Carolus Hospital, Jakarta, Indonesia Bone and Joint Center, St. Carolus Hospital, Jakarta, IndonesiaLow back pain is one of the leading causes of disability in the world. Regenerative medicine can be one of the novel treatment breakthroughs in patients with low back pain, yet its use is still debatable. We performed a systematic evaluation and meta-analysis to determine the efficacy of platelet-rich plasma (PRP) treatment for patients with chronic low back pain. Comprehensive database searches were performed in four databases. This study was conducted and reported based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses Guideline and registered to PROSPERO. We included and examined randomized controlled trials that looked into research employing PRP for patients with chronic low back pain. Outcomes of interest include clinical enhancement of pain, which is demonstrated in pain scores. Three studies were included comprising 138 patients with chronic low back pain. After 1, 3, and 6 months after injection, there was a substantial reduction in the pain score difference between the PRP and control groups, demonstrating PRP’s superiority over the control group in the treatment of chronic low back pain. PRP injection significantly enhances chronic low back pain in the first, third, and sixth months after injection compared to controls.http://www.asianspinejournal.org/upload/pdf/asj-2022-0209.pdfplatelet-rich plasmachronic low back painregenerative medicineinjections |
| spellingShingle | Leonard Christianto Singjie Samuel Andi Kusuma Ifran Saleh Erica Kholinne The Potency of Platelet-Rich Plasma for Chronic Low Back Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trial Asian Spine Journal platelet-rich plasma chronic low back pain regenerative medicine injections |
| title | The Potency of Platelet-Rich Plasma for Chronic Low Back Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trial |
| title_full | The Potency of Platelet-Rich Plasma for Chronic Low Back Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trial |
| title_fullStr | The Potency of Platelet-Rich Plasma for Chronic Low Back Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trial |
| title_full_unstemmed | The Potency of Platelet-Rich Plasma for Chronic Low Back Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trial |
| title_short | The Potency of Platelet-Rich Plasma for Chronic Low Back Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trial |
| title_sort | potency of platelet rich plasma for chronic low back pain a systematic review and meta analysis of randomized controlled trial |
| topic | platelet-rich plasma chronic low back pain regenerative medicine injections |
| url | http://www.asianspinejournal.org/upload/pdf/asj-2022-0209.pdf |
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