Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination
The epidermis is a multi-layered epithelium formed by the differentiation of basal cells and movement into suprabasal layers. Here the authors define a role for the desmosomal cadherin desmoglein-1 in promoting the delamination of basal cells by remodeling the actin cytoskeleton through interactions...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03414-6 |
| _version_ | 1818341912129568768 |
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| author | Oxana Nekrasova Robert M. Harmon Joshua A. Broussard Jennifer L. Koetsier Lisa M. Godsel Gillian N. Fitz Margaret L. Gardel Kathleen J. Green |
| author_facet | Oxana Nekrasova Robert M. Harmon Joshua A. Broussard Jennifer L. Koetsier Lisa M. Godsel Gillian N. Fitz Margaret L. Gardel Kathleen J. Green |
| author_sort | Oxana Nekrasova |
| collection | DOAJ |
| description | The epidermis is a multi-layered epithelium formed by the differentiation of basal cells and movement into suprabasal layers. Here the authors define a role for the desmosomal cadherin desmoglein-1 in promoting the delamination of basal cells by remodeling the actin cytoskeleton through interactions with the dynein light chain Tctex-1 and cortactin. |
| first_indexed | 2024-12-13T16:06:20Z |
| format | Article |
| id | doaj.art-f8d863c46db64eadbafdd04712ce57e4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:06:20Z |
| publishDate | 2018-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f8d863c46db64eadbafdd04712ce57e42022-12-21T23:39:02ZengNature PortfolioNature Communications2041-17232018-03-019111810.1038/s41467-018-03414-6Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delaminationOxana Nekrasova0Robert M. Harmon1Joshua A. Broussard2Jennifer L. Koetsier3Lisa M. Godsel4Gillian N. Fitz5Margaret L. Gardel6Kathleen J. Green7Department of Pathology, Northwestern University Feinberg School of MedicineDepartment of Pathology, Northwestern University Feinberg School of MedicineDepartment of Pathology, Northwestern University Feinberg School of MedicineDepartment of Pathology, Northwestern University Feinberg School of MedicineDepartment of Pathology, Northwestern University Feinberg School of MedicineDepartment of Pathology, Northwestern University Feinberg School of MedicineInstitute for Biophysical Dynamics, University of ChicagoDepartment of Pathology, Northwestern University Feinberg School of MedicineThe epidermis is a multi-layered epithelium formed by the differentiation of basal cells and movement into suprabasal layers. Here the authors define a role for the desmosomal cadherin desmoglein-1 in promoting the delamination of basal cells by remodeling the actin cytoskeleton through interactions with the dynein light chain Tctex-1 and cortactin.https://doi.org/10.1038/s41467-018-03414-6 |
| spellingShingle | Oxana Nekrasova Robert M. Harmon Joshua A. Broussard Jennifer L. Koetsier Lisa M. Godsel Gillian N. Fitz Margaret L. Gardel Kathleen J. Green Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination Nature Communications |
| title | Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination |
| title_full | Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination |
| title_fullStr | Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination |
| title_full_unstemmed | Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination |
| title_short | Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination |
| title_sort | desmosomal cadherin association with tctex 1 and cortactin arp2 3 drives perijunctional actin polymerization to promote keratinocyte delamination |
| url | https://doi.org/10.1038/s41467-018-03414-6 |
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