Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis
A new method for metronidazole determination, based on spectrometric monitoring of a diazonium salt produced in-line by alkaline hydrolysis released nitrite ions, was developed and successfully applied to pharmaceutical tablets (r = 0.9993, 2.0-20.0 mg L-1, DL = 0.7 mg L-1) with no interference from...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2006-01-01
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| Series: | Journal of the Brazilian Chemical Society |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000300028 |
| _version_ | 1811282851769876480 |
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| author | Simões Simone S. Medeiros Everaldo P. Gaião Edvaldo N. Lyra Wellington S. Moreira Pablo N. T. Araújo Mario C. U. Silva Edvan C. Nascimento Valberes B. |
| author_facet | Simões Simone S. Medeiros Everaldo P. Gaião Edvaldo N. Lyra Wellington S. Moreira Pablo N. T. Araújo Mario C. U. Silva Edvan C. Nascimento Valberes B. |
| author_sort | Simões Simone S. |
| collection | DOAJ |
| description | A new method for metronidazole determination, based on spectrometric monitoring of a diazonium salt produced in-line by alkaline hydrolysis released nitrite ions, was developed and successfully applied to pharmaceutical tablets (r = 0.9993, 2.0-20.0 mg L-1, DL = 0.7 mg L-1) with no interference from common ingredients accompanying the drug. |
| first_indexed | 2024-04-13T01:59:59Z |
| format | Article |
| id | doaj.art-f8d8fc603c8e4196ba5254c68812ab15 |
| institution | Directory Open Access Journal |
| issn | 0103-5053 1678-4790 |
| language | English |
| last_indexed | 2024-04-13T01:59:59Z |
| publishDate | 2006-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Journal of the Brazilian Chemical Society |
| spelling | doaj.art-f8d8fc603c8e4196ba5254c68812ab152022-12-22T03:07:40ZengSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society0103-50531678-47902006-01-01173609613Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysisSimões Simone S.Medeiros Everaldo P.Gaião Edvaldo N.Lyra Wellington S.Moreira Pablo N. T.Araújo Mario C. U.Silva Edvan C.Nascimento Valberes B.A new method for metronidazole determination, based on spectrometric monitoring of a diazonium salt produced in-line by alkaline hydrolysis released nitrite ions, was developed and successfully applied to pharmaceutical tablets (r = 0.9993, 2.0-20.0 mg L-1, DL = 0.7 mg L-1) with no interference from common ingredients accompanying the drug.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000300028flow injection analysisspectrophotometrypharmaceuticalsmetronidazolenitrite |
| spellingShingle | Simões Simone S. Medeiros Everaldo P. Gaião Edvaldo N. Lyra Wellington S. Moreira Pablo N. T. Araújo Mario C. U. Silva Edvan C. Nascimento Valberes B. Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis Journal of the Brazilian Chemical Society flow injection analysis spectrophotometry pharmaceuticals metronidazole nitrite |
| title | Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis |
| title_full | Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis |
| title_fullStr | Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis |
| title_full_unstemmed | Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis |
| title_short | Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis |
| title_sort | flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis |
| topic | flow injection analysis spectrophotometry pharmaceuticals metronidazole nitrite |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000300028 |
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