Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P2/STAT3 Signaling Pathway

Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P2/STAT3 Signaling Pathway

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that activates a family of G protein coupled-receptors (GPCRs) implicated in mammalian development, angiogenesis, immunity and tissue regeneration. S1P functions as a trophic factor for many cell types, including embryonic stem cells (ESCs)....

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Bibliographic Details
Main Authors: Gaelen S. Smith, Julie D. Saba, Ashok Kumar
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Biomolecules
Subjects:
sphingosine-1-phosphate
sphingosine phosphate lyase
embryonic stem cell
S1P2
pluripotency
proliferation
STAT3
Online Access:http://www.mdpi.com/2218-273X/3/3/351

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