The Efficiency of Hydroxychloroquine for the Treatment of Primary Sjögren’s Syndrome: A Systematic Review and Meta-Analysis
Objectives: This meta-analysis was conducted to evaluate the effects of hydroxychloroquine (HCQ) in the treatment of primary Sjögren’s syndrome (pSS).Methods: Nine databases were searched for data collection. We used clinical features, including involvement in superficial tissues and visceral system...
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.693796/full |
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| author | Xuan Wang Tongyangzi Zhang Zizhen Guo Jincheng Pu Farooq Riaz Run Feng Xingxing Fang Jiamin Song Yuanyuan Liang Zhenzhen Wu Shengnan Pan Jianping Tang |
| author_facet | Xuan Wang Tongyangzi Zhang Zizhen Guo Jincheng Pu Farooq Riaz Run Feng Xingxing Fang Jiamin Song Yuanyuan Liang Zhenzhen Wu Shengnan Pan Jianping Tang |
| author_sort | Xuan Wang |
| collection | DOAJ |
| description | Objectives: This meta-analysis was conducted to evaluate the effects of hydroxychloroquine (HCQ) in the treatment of primary Sjögren’s syndrome (pSS).Methods: Nine databases were searched for data collection. We used clinical features, including involvement in superficial tissues and visceral systems, and experimental findings, including Schirmer’s test, unstimulated salivary flow rate (uSFR), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and immunoglobulins (IgG, IgM and IgA) as major outcome measures. The Downs and Black quality assessment tool and RevMan 5.3 were used to assess the methodological quality and statistical analysis, respectively.Results: Thirteen studies with pSS patients, consisting of two randomized controlled studies, four retrospective studies and seven prospective studies were analyzed. Results showed that HCQ treatment significantly improved the oral symptoms of pSS patients compared to non-HCQ treatment (P = 0.003). Similar trends favoring HCQ treatment were observed for uSFR (p = 0.05), CRP (p = 0.0008), ESR (p < 0.00001), IgM (p = 0.007) and IgA (p = 0.05). However, no significant improvement was observed in other clinical features, including ocular involvement, fatigue, articular lesions, pulmonary, neurological and lymphoproliferative symptoms, renal organs and other experimental parameters in the HCQ treatment group compared to the non-HCQ treatment group.Conclusion: HCQ treatment showed moderate efficacy to improve oral symptoms, uSFR, ESR, CRP, IgM and IgA. However, HCQ could not alleviate organ-specific systemic involvement.Systematic Review Registration:We have registered on the PROSPERO [https://www.crd.york.ac.uk/PROSPERO/], and the registration number is identifier [CRD42020205624] |
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| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-22T00:46:32Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-f8da5081d7b24f42b7ec93f23707d33f2022-12-21T18:44:33ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-09-011210.3389/fphar.2021.693796693796The Efficiency of Hydroxychloroquine for the Treatment of Primary Sjögren’s Syndrome: A Systematic Review and Meta-AnalysisXuan Wang0Tongyangzi Zhang1Zizhen Guo2Jincheng Pu3Farooq Riaz4Run Feng5Xingxing Fang6Jiamin Song7Yuanyuan Liang8Zhenzhen Wu9Shengnan Pan10Jianping Tang11Department of Rheumatology and Immunology, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaObjectives: This meta-analysis was conducted to evaluate the effects of hydroxychloroquine (HCQ) in the treatment of primary Sjögren’s syndrome (pSS).Methods: Nine databases were searched for data collection. We used clinical features, including involvement in superficial tissues and visceral systems, and experimental findings, including Schirmer’s test, unstimulated salivary flow rate (uSFR), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and immunoglobulins (IgG, IgM and IgA) as major outcome measures. The Downs and Black quality assessment tool and RevMan 5.3 were used to assess the methodological quality and statistical analysis, respectively.Results: Thirteen studies with pSS patients, consisting of two randomized controlled studies, four retrospective studies and seven prospective studies were analyzed. Results showed that HCQ treatment significantly improved the oral symptoms of pSS patients compared to non-HCQ treatment (P = 0.003). Similar trends favoring HCQ treatment were observed for uSFR (p = 0.05), CRP (p = 0.0008), ESR (p < 0.00001), IgM (p = 0.007) and IgA (p = 0.05). However, no significant improvement was observed in other clinical features, including ocular involvement, fatigue, articular lesions, pulmonary, neurological and lymphoproliferative symptoms, renal organs and other experimental parameters in the HCQ treatment group compared to the non-HCQ treatment group.Conclusion: HCQ treatment showed moderate efficacy to improve oral symptoms, uSFR, ESR, CRP, IgM and IgA. However, HCQ could not alleviate organ-specific systemic involvement.Systematic Review Registration:We have registered on the PROSPERO [https://www.crd.york.ac.uk/PROSPERO/], and the registration number is identifier [CRD42020205624]https://www.frontiersin.org/articles/10.3389/fphar.2021.693796/fullhydroxychloroquineSjögren’s syndromesystematic reviewmeta-analysistreatmemt |
| spellingShingle | Xuan Wang Tongyangzi Zhang Zizhen Guo Jincheng Pu Farooq Riaz Run Feng Xingxing Fang Jiamin Song Yuanyuan Liang Zhenzhen Wu Shengnan Pan Jianping Tang The Efficiency of Hydroxychloroquine for the Treatment of Primary Sjögren’s Syndrome: A Systematic Review and Meta-Analysis Frontiers in Pharmacology hydroxychloroquine Sjögren’s syndrome systematic review meta-analysis treatmemt |
| title | The Efficiency of Hydroxychloroquine for the Treatment of Primary Sjögren’s Syndrome: A Systematic Review and Meta-Analysis |
| title_full | The Efficiency of Hydroxychloroquine for the Treatment of Primary Sjögren’s Syndrome: A Systematic Review and Meta-Analysis |
| title_fullStr | The Efficiency of Hydroxychloroquine for the Treatment of Primary Sjögren’s Syndrome: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Efficiency of Hydroxychloroquine for the Treatment of Primary Sjögren’s Syndrome: A Systematic Review and Meta-Analysis |
| title_short | The Efficiency of Hydroxychloroquine for the Treatment of Primary Sjögren’s Syndrome: A Systematic Review and Meta-Analysis |
| title_sort | efficiency of hydroxychloroquine for the treatment of primary sjogren s syndrome a systematic review and meta analysis |
| topic | hydroxychloroquine Sjögren’s syndrome systematic review meta-analysis treatmemt |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.693796/full |
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