Effect of Non-Modified as Well as Surface-Modified SiO<sub>2</sub> Nanoparticles on Red Blood Cells, Biological and Model Membranes
Nanoparticles are extremely promising components that are used in diagnostics and medical therapies. Among them, silica nanoparticles are ultrafine materials that, due to their unique physicochemical properties, have already been used in biomedicine, for instance, in cancer therapy. The aim of this...
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MDPI AG
2023-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/14/11760 |
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| author | Katarzyna Solarska-Ściuk Katarzyna Męczarska Vera Jencova Patryk Jędrzejczak Łukasz Klapiszewski Aleksandra Jaworska Monika Hryć Dorota Bonarska-Kujawa |
| author_facet | Katarzyna Solarska-Ściuk Katarzyna Męczarska Vera Jencova Patryk Jędrzejczak Łukasz Klapiszewski Aleksandra Jaworska Monika Hryć Dorota Bonarska-Kujawa |
| author_sort | Katarzyna Solarska-Ściuk |
| collection | DOAJ |
| description | Nanoparticles are extremely promising components that are used in diagnostics and medical therapies. Among them, silica nanoparticles are ultrafine materials that, due to their unique physicochemical properties, have already been used in biomedicine, for instance, in cancer therapy. The aim of this study was to investigate the cytotoxicity of three types of nanoparticles (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>SiO</mi><mn>2</mn></msub></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>SiO</mi><mn>2</mn></msub><mtext>-</mtext><mi>SH</mi></mrow></semantics></math></inline-formula>, and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>SiO</mi><mn>2</mn></msub><mtext>-</mtext><mi>COOH</mi></mrow></semantics></math></inline-formula>) in relation to red blood cells, as well as the impact of silicon dioxide nanoparticles on biological membranes and liposome models of membranes. The results obtained prove that hemolytic toxicity depends on the concentration of nanoparticles and the incubation period. Silica nanoparticles have a marginal impact on the changes in the osmotic resistance of erythrocytes, except for <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>SiO</mi><mn>2</mn></msub><mtext>-</mtext><mi>COOH</mi></mrow></semantics></math></inline-formula>, which, similarly to <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>SiO</mi><mn>2</mn></msub></semantics></math></inline-formula> and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>SiO</mi><mn>2</mn></msub><mtext>-</mtext><mi>SH</mi></mrow></semantics></math></inline-formula>, changes the shape of erythrocytes from discocytes mainly towards echinocytes. What is more, nanosilica has an impact on the change in fluidity of biological and model membranes. The research gives a new view of the practical possibilities for the use of large-grain nanoparticles in biomedicine. |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T01:00:13Z |
| publishDate | 2023-07-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f8dc5affa37043b3888521dc25aa7c552023-11-18T19:44:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-07-0124141176010.3390/ijms241411760Effect of Non-Modified as Well as Surface-Modified SiO<sub>2</sub> Nanoparticles on Red Blood Cells, Biological and Model MembranesKatarzyna Solarska-Ściuk0Katarzyna Męczarska1Vera Jencova2Patryk Jędrzejczak3Łukasz Klapiszewski4Aleksandra Jaworska5Monika Hryć6Dorota Bonarska-Kujawa7Department of Physics and Biophysics, Wrocław University of Environmental and Life Sciences, Norwida St. 25, 50-375 Wrocław, PolandDepartment of Physics and Biophysics, Wrocław University of Environmental and Life Sciences, Norwida St. 25, 50-375 Wrocław, PolandDepartment of Chemistry, Faculty of Science, Humanities and Education, Technical University of Liberec, Studentska 2, 461 17 Liberec, Czech RepublicInstitute of Chemical Technology and Engineering, Faculty of Chemical Technology, Poznan University of Technology, Berdychowo 4, 60-965 Poznan, PolandInstitute of Chemical Technology and Engineering, Faculty of Chemical Technology, Poznan University of Technology, Berdychowo 4, 60-965 Poznan, PolandDepartment of Physics and Biophysics, Wrocław University of Environmental and Life Sciences, Norwida St. 25, 50-375 Wrocław, PolandDepartment of Physics and Biophysics, Wrocław University of Environmental and Life Sciences, Norwida St. 25, 50-375 Wrocław, PolandDepartment of Physics and Biophysics, Wrocław University of Environmental and Life Sciences, Norwida St. 25, 50-375 Wrocław, PolandNanoparticles are extremely promising components that are used in diagnostics and medical therapies. Among them, silica nanoparticles are ultrafine materials that, due to their unique physicochemical properties, have already been used in biomedicine, for instance, in cancer therapy. The aim of this study was to investigate the cytotoxicity of three types of nanoparticles (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>SiO</mi><mn>2</mn></msub></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>SiO</mi><mn>2</mn></msub><mtext>-</mtext><mi>SH</mi></mrow></semantics></math></inline-formula>, and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>SiO</mi><mn>2</mn></msub><mtext>-</mtext><mi>COOH</mi></mrow></semantics></math></inline-formula>) in relation to red blood cells, as well as the impact of silicon dioxide nanoparticles on biological membranes and liposome models of membranes. The results obtained prove that hemolytic toxicity depends on the concentration of nanoparticles and the incubation period. Silica nanoparticles have a marginal impact on the changes in the osmotic resistance of erythrocytes, except for <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>SiO</mi><mn>2</mn></msub><mtext>-</mtext><mi>COOH</mi></mrow></semantics></math></inline-formula>, which, similarly to <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>SiO</mi><mn>2</mn></msub></semantics></math></inline-formula> and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>SiO</mi><mn>2</mn></msub><mtext>-</mtext><mi>SH</mi></mrow></semantics></math></inline-formula>, changes the shape of erythrocytes from discocytes mainly towards echinocytes. What is more, nanosilica has an impact on the change in fluidity of biological and model membranes. The research gives a new view of the practical possibilities for the use of large-grain nanoparticles in biomedicine.https://www.mdpi.com/1422-0067/24/14/11760silica nanoparticleshemolytic toxicityosmotic resistancebiological membraneserythrocyteserythrocyte membranes |
| spellingShingle | Katarzyna Solarska-Ściuk Katarzyna Męczarska Vera Jencova Patryk Jędrzejczak Łukasz Klapiszewski Aleksandra Jaworska Monika Hryć Dorota Bonarska-Kujawa Effect of Non-Modified as Well as Surface-Modified SiO<sub>2</sub> Nanoparticles on Red Blood Cells, Biological and Model Membranes International Journal of Molecular Sciences silica nanoparticles hemolytic toxicity osmotic resistance biological membranes erythrocytes erythrocyte membranes |
| title | Effect of Non-Modified as Well as Surface-Modified SiO<sub>2</sub> Nanoparticles on Red Blood Cells, Biological and Model Membranes |
| title_full | Effect of Non-Modified as Well as Surface-Modified SiO<sub>2</sub> Nanoparticles on Red Blood Cells, Biological and Model Membranes |
| title_fullStr | Effect of Non-Modified as Well as Surface-Modified SiO<sub>2</sub> Nanoparticles on Red Blood Cells, Biological and Model Membranes |
| title_full_unstemmed | Effect of Non-Modified as Well as Surface-Modified SiO<sub>2</sub> Nanoparticles on Red Blood Cells, Biological and Model Membranes |
| title_short | Effect of Non-Modified as Well as Surface-Modified SiO<sub>2</sub> Nanoparticles on Red Blood Cells, Biological and Model Membranes |
| title_sort | effect of non modified as well as surface modified sio sub 2 sub nanoparticles on red blood cells biological and model membranes |
| topic | silica nanoparticles hemolytic toxicity osmotic resistance biological membranes erythrocytes erythrocyte membranes |
| url | https://www.mdpi.com/1422-0067/24/14/11760 |
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