Association of APOE genotype with CT markers of cerebral amyloid angiopathy in spontaneous intracerebral haemorrhage
Background and objective We investigated the association of APOE alleles with CT-based cerebral amyloid angiopathy (CAA) markers including subarachnoid extension (SAE) and finger-like projection (FLP).Methods We included patients with acute primary supratentorial intracerebral haemorrhage (ICH) from...
| Glavni autori: | , , , , , , , , |
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| Format: | Članak |
| Jezik: | English |
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BMJ Publishing Group
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| Serija: | Stroke and Vascular Neurology |
| Online pristup: | https://svn.bmj.com/content/early/2024/12/08/svn-2024-003477.full |
| _version_ | 1826930498981593088 |
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| author | Feng Gao Lu Tang Dongsheng Fan Nan Li Xu Huang Xiaolu Liu Qiong Yang Xiangzhu Zeng Kailin Xia |
| author_facet | Feng Gao Lu Tang Dongsheng Fan Nan Li Xu Huang Xiaolu Liu Qiong Yang Xiangzhu Zeng Kailin Xia |
| author_sort | Feng Gao |
| collection | DOAJ |
| description | Background and objective We investigated the association of APOE alleles with CT-based cerebral amyloid angiopathy (CAA) markers including subarachnoid extension (SAE) and finger-like projection (FLP).Methods We included patients with acute primary supratentorial intracerebral haemorrhage (ICH) from a multicentre cohort in China. First, the association of APOE with ICH location (lobar vs non-lobar) was evaluated. Next, the relationships of APOE with SAE, FLP, and the coexistence of the two (SAE+FLP) were evaluated.Results 533 patients with supratentorial ICH were enrolled. Among them were 138 patients with lobar ICH and 395 with non-lobar ICH. Compared with the non-lobar group, APOE ε4 (OR 1.894, 95% CI 1.138 to 3.154, p=0.014) and ε2/ε4 (OR 6.098, 95% CI 1.414 to 26.293, p=0.015) were associated with lobar ICH. With regard to CAA markers, APOE ε2 was associated with SAE (OR 2.109, 95% CI 1.167 to 3.810, p=0.013), ε4 was associated with FLP and SAE+FLP (OR 3.026, 95% CI 1.353 to 6.767, p=0.007; OR 3.514, 95% CI 1.485 to 8.316, p=0.004, respectively) and ε2/ε4 was associated with all three factors (SAH: OR 7.599, 95% CI 1.764 to 32.734, p=0.006; FLP: OR 20.333, 95% CI 3.278 to 126.137, p=0.001; SAE+FLP: OR 30.568, 95% CI 4.460 to 209.503, p<0.001) after adjusting for age, and remained significant after adjusting for age and ICH volume.Conclusion In patients with spontaneous supratentorial ICH, APOE ε2 and ε4 alleles were associated with SAE and FLP, respectively, suggesting APOE allele-specific effects on CT markers of CAA and their potential mechanisms. |
| first_indexed | 2025-02-17T16:28:47Z |
| format | Article |
| id | doaj.art-f8de80abceb94e459839ba8ec231ba08 |
| institution | Directory Open Access Journal |
| issn | 2059-8696 |
| language | English |
| last_indexed | 2025-02-17T16:28:47Z |
| publisher | BMJ Publishing Group |
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| series | Stroke and Vascular Neurology |
| spelling | doaj.art-f8de80abceb94e459839ba8ec231ba082024-12-17T06:10:11ZengBMJ Publishing GroupStroke and Vascular Neurology2059-869610.1136/svn-2024-003477Association of APOE genotype with CT markers of cerebral amyloid angiopathy in spontaneous intracerebral haemorrhageFeng Gao0Lu Tang1Dongsheng Fan2Nan Li3Xu Huang4Xiaolu Liu5Qiong Yang6Xiangzhu Zeng7Kailin Xia8Department of Neurosurgery, Peking University Shougang Hospital, Beijing, ChinaDepartment of Neurology, Peking University Third Hospital, Beijing, ChinaDepartment of Neurology, Peking University Third Hospital, Beijing, ChinaResearch Center of Clincial Epidemiology, Peking University Third Hospital, Beijing, ChinaDepartment of Neurosurgery, Peking University Shougang Hospital, Beijing, ChinaDepartment of Neurology, Peking University Third Hospital, Beijing, ChinaDepartment of Neurology, Peking University Third Hospital, Beijing, ChinaDepartment of Radiology, Peking University Third Hospital, Beijing, ChinaDepartment of Neurology, Peking University Third Hospital, Beijing, ChinaBackground and objective We investigated the association of APOE alleles with CT-based cerebral amyloid angiopathy (CAA) markers including subarachnoid extension (SAE) and finger-like projection (FLP).Methods We included patients with acute primary supratentorial intracerebral haemorrhage (ICH) from a multicentre cohort in China. First, the association of APOE with ICH location (lobar vs non-lobar) was evaluated. Next, the relationships of APOE with SAE, FLP, and the coexistence of the two (SAE+FLP) were evaluated.Results 533 patients with supratentorial ICH were enrolled. Among them were 138 patients with lobar ICH and 395 with non-lobar ICH. Compared with the non-lobar group, APOE ε4 (OR 1.894, 95% CI 1.138 to 3.154, p=0.014) and ε2/ε4 (OR 6.098, 95% CI 1.414 to 26.293, p=0.015) were associated with lobar ICH. With regard to CAA markers, APOE ε2 was associated with SAE (OR 2.109, 95% CI 1.167 to 3.810, p=0.013), ε4 was associated with FLP and SAE+FLP (OR 3.026, 95% CI 1.353 to 6.767, p=0.007; OR 3.514, 95% CI 1.485 to 8.316, p=0.004, respectively) and ε2/ε4 was associated with all three factors (SAH: OR 7.599, 95% CI 1.764 to 32.734, p=0.006; FLP: OR 20.333, 95% CI 3.278 to 126.137, p=0.001; SAE+FLP: OR 30.568, 95% CI 4.460 to 209.503, p<0.001) after adjusting for age, and remained significant after adjusting for age and ICH volume.Conclusion In patients with spontaneous supratentorial ICH, APOE ε2 and ε4 alleles were associated with SAE and FLP, respectively, suggesting APOE allele-specific effects on CT markers of CAA and their potential mechanisms.https://svn.bmj.com/content/early/2024/12/08/svn-2024-003477.full |
| spellingShingle | Feng Gao Lu Tang Dongsheng Fan Nan Li Xu Huang Xiaolu Liu Qiong Yang Xiangzhu Zeng Kailin Xia Association of APOE genotype with CT markers of cerebral amyloid angiopathy in spontaneous intracerebral haemorrhage Stroke and Vascular Neurology |
| title | Association of APOE genotype with CT markers of cerebral amyloid angiopathy in spontaneous intracerebral haemorrhage |
| title_full | Association of APOE genotype with CT markers of cerebral amyloid angiopathy in spontaneous intracerebral haemorrhage |
| title_fullStr | Association of APOE genotype with CT markers of cerebral amyloid angiopathy in spontaneous intracerebral haemorrhage |
| title_full_unstemmed | Association of APOE genotype with CT markers of cerebral amyloid angiopathy in spontaneous intracerebral haemorrhage |
| title_short | Association of APOE genotype with CT markers of cerebral amyloid angiopathy in spontaneous intracerebral haemorrhage |
| title_sort | association of apoe genotype with ct markers of cerebral amyloid angiopathy in spontaneous intracerebral haemorrhage |
| url | https://svn.bmj.com/content/early/2024/12/08/svn-2024-003477.full |
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