Amelioration of social isolation-triggered onset of early Alzheimer's disease-related cognitive deficit by N-acetylcysteine in a transgenic mouse model

Amelioration of social isolation-triggered onset of early Alzheimer's disease-related cognitive deficit by N-acetylcysteine in a transgenic mouse model

Epidemiological study reveals that socially isolated persons have increased risk of developing Alzheimer's disease (AD). Whether this risk arises from an oxidative stress is unclear. Here we show that N-acetylcysteine (NAC), an anti-oxidant, is capable of preventing social isolation-induced acc...

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Bibliographic Details
Main Authors: Ya-Hsin Hsiao, Jinn-Rung Kuo, Shun-Hua Chen, Po-Wu Gean
Format: Article
Language:English
Published: Elsevier 2012-03-01
Series:Neurobiology of Disease
Subjects:
Social isolation
Amyloid-β peptide
Long-term potentiation
Learning and memory
Alzheimer's disease
N-acetylcysteine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111004062

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