Biosynthesis, characterization, and investigation of antimicrobial and cytotoxic activities of silver nanoparticles using Solanum tuberosum peel aqueous extract
Metallic nanoparticle biosynthesis is thought to offer opportunities for a wide range of biological uses. The green process of turning biological waste into utilizable products gaining attention due to its economical and eco-friendly approach in recent years. This study reported the ability of Solan...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023062692 |
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| author | Jiajun Xu Mahmut Yıldıztekin Dayong Han Cumali Keskin Ayşe Baran Mehmet Fırat Baran Aziz Eftekhari Canan Aytuğ Ava Sevgi İrtegün Kandemir Deniz Bariş Cebe Beşir Dağ Aferin Beilerli Rovshan Khalilov |
| author_facet | Jiajun Xu Mahmut Yıldıztekin Dayong Han Cumali Keskin Ayşe Baran Mehmet Fırat Baran Aziz Eftekhari Canan Aytuğ Ava Sevgi İrtegün Kandemir Deniz Bariş Cebe Beşir Dağ Aferin Beilerli Rovshan Khalilov |
| author_sort | Jiajun Xu |
| collection | DOAJ |
| description | Metallic nanoparticle biosynthesis is thought to offer opportunities for a wide range of biological uses. The green process of turning biological waste into utilizable products gaining attention due to its economical and eco-friendly approach in recent years. This study reported the ability of Solanum tuberosum (ST) peel extract to the green synthesis of non-toxic, stable, small-sized silver nanoparticles without any toxic reducing agent utilizing the phytochemical components present in its structure. UV–visible spectroscopy, X-ray diffraction analysis, Fourier transform infrared spectroscopy, flourier scanning electron microscopy, atomic force microscopy, transmission electron microscopy, and energy dispersive analysis X-ray confirmed the biosynthesis and characterization of silver nanoparticles. Also, dynamic light scattering and thermogravimetric analyses showed stable synthesized nanoparticles. The antibacterial activity of the biosynthesized silver nanoparticles was evaluated against four different bacterial strains, Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Staphylococcus aureus (S. aureus) Bacillus subtilis (B. subtilis), and a yeast, Candida albicans (C. albicans) using the minimum inhibitory concentration technique. The cytotoxic activities were determined against Human dermal fibroblast (HDF), glioblastoma (U118), colorectal adenocarcinoma (CaCo-2), and human ovarian (Skov-3) cell lines cancer cells using MTT test. The nanoparticle capping agents that could be involved in the reduction of silver ions to Ag NPs and their stabilization was identified using FTIR. Nanoparticles were spherical in shape and had a size ranging from 3.91 to 27.07 nm, showed crystalline nature, good stability (−31.3 mV), and the presence of capping agents. ST-Ag NPs significantly decreased the growth of bacterial strains after treatment. The in vitro analysis showed that the ST-Ag NPs demonstrated dose-dependent cytotoxicity against cell lines. Based on the data, it is feasible to infer that biogenic Ag NPs were capped with functional groups and demonstrated considerable potential as antibacterial and anticancer agents for biomedical and industrial applications. |
| first_indexed | 2024-03-12T12:21:13Z |
| format | Article |
| id | doaj.art-f8dfc36d07d142dd9dea095cb6ffa6a8 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-12T12:21:13Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-f8dfc36d07d142dd9dea095cb6ffa6a82023-08-30T05:53:36ZengElsevierHeliyon2405-84402023-08-0198e19061Biosynthesis, characterization, and investigation of antimicrobial and cytotoxic activities of silver nanoparticles using Solanum tuberosum peel aqueous extractJiajun Xu0Mahmut Yıldıztekin1Dayong Han2Cumali Keskin3Ayşe Baran4Mehmet Fırat Baran5Aziz Eftekhari6Canan Aytuğ Ava7Sevgi İrtegün Kandemir8Deniz Bariş Cebe9Beşir Dağ10Aferin Beilerli11Rovshan Khalilov12Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Str,Nangang District,Harbin,P.R.China, 150001Department of Herbal and Animal Production, Koycegiz Vocational School, Muğla Sıtkı Kocman University, Mugla, TurkeyDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Str,Nangang District,Harbin,P.R.China, 150001; Corresponding author.Department of Medical Services and Techniques, Vocational School of Health Services, Mardin Artuklu University, Mardin, Turkey; Corresponding author.Department of Biology, Graduate Education Institute, Mardin Artuklu University, Mardin, TurkeyDepartment of Food Technology, Vocational School of Technical Sciences, Batman University, Batman, TurkeyDepartment of Biochemistry, Faculty of Science, Ege University, Izmir, Turkey; Nanotechnology and Biochemical Toxicology (NBT) center, Azerbaijan State University of Economics (UNEC), Baku AZ1001, Azerbaijan; Corresponding author.Dicle University Science and Technology Application and Research Center, Dicle University, Diyarbakır, TurkeyDepartment of Medical Biology, Dicle University Central Research Laboratory, Faculty of Medicine, Dicle University, Diyarbakir, TurkeyDepartment of Chemistry, Batman University, Batman, TurkeyDepartment of Chemistry, Batman University, Batman, TurkeyDepartment of Obstetrics and Gynecology, Tyumen State Medical University, 54 Odesskaya Street, 625023, Tyumen, RussiaDepartment of Biophysics and Biochemistry, Baku State University, Baku, Azerbaijan; Nanotechnology and Biochemical Toxicology (NBT) center, Azerbaijan State University of Economics (UNEC), Baku AZ1001, AzerbaijanMetallic nanoparticle biosynthesis is thought to offer opportunities for a wide range of biological uses. The green process of turning biological waste into utilizable products gaining attention due to its economical and eco-friendly approach in recent years. This study reported the ability of Solanum tuberosum (ST) peel extract to the green synthesis of non-toxic, stable, small-sized silver nanoparticles without any toxic reducing agent utilizing the phytochemical components present in its structure. UV–visible spectroscopy, X-ray diffraction analysis, Fourier transform infrared spectroscopy, flourier scanning electron microscopy, atomic force microscopy, transmission electron microscopy, and energy dispersive analysis X-ray confirmed the biosynthesis and characterization of silver nanoparticles. Also, dynamic light scattering and thermogravimetric analyses showed stable synthesized nanoparticles. The antibacterial activity of the biosynthesized silver nanoparticles was evaluated against four different bacterial strains, Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Staphylococcus aureus (S. aureus) Bacillus subtilis (B. subtilis), and a yeast, Candida albicans (C. albicans) using the minimum inhibitory concentration technique. The cytotoxic activities were determined against Human dermal fibroblast (HDF), glioblastoma (U118), colorectal adenocarcinoma (CaCo-2), and human ovarian (Skov-3) cell lines cancer cells using MTT test. The nanoparticle capping agents that could be involved in the reduction of silver ions to Ag NPs and their stabilization was identified using FTIR. Nanoparticles were spherical in shape and had a size ranging from 3.91 to 27.07 nm, showed crystalline nature, good stability (−31.3 mV), and the presence of capping agents. ST-Ag NPs significantly decreased the growth of bacterial strains after treatment. The in vitro analysis showed that the ST-Ag NPs demonstrated dose-dependent cytotoxicity against cell lines. Based on the data, it is feasible to infer that biogenic Ag NPs were capped with functional groups and demonstrated considerable potential as antibacterial and anticancer agents for biomedical and industrial applications.http://www.sciencedirect.com/science/article/pii/S2405844023062692Antimicrobial activityCytotoxic activityBiogenic silver nanoparticlesSolanum tuberosum L.Nanomedicine |
| spellingShingle | Jiajun Xu Mahmut Yıldıztekin Dayong Han Cumali Keskin Ayşe Baran Mehmet Fırat Baran Aziz Eftekhari Canan Aytuğ Ava Sevgi İrtegün Kandemir Deniz Bariş Cebe Beşir Dağ Aferin Beilerli Rovshan Khalilov Biosynthesis, characterization, and investigation of antimicrobial and cytotoxic activities of silver nanoparticles using Solanum tuberosum peel aqueous extract Heliyon Antimicrobial activity Cytotoxic activity Biogenic silver nanoparticles Solanum tuberosum L. Nanomedicine |
| title | Biosynthesis, characterization, and investigation of antimicrobial and cytotoxic activities of silver nanoparticles using Solanum tuberosum peel aqueous extract |
| title_full | Biosynthesis, characterization, and investigation of antimicrobial and cytotoxic activities of silver nanoparticles using Solanum tuberosum peel aqueous extract |
| title_fullStr | Biosynthesis, characterization, and investigation of antimicrobial and cytotoxic activities of silver nanoparticles using Solanum tuberosum peel aqueous extract |
| title_full_unstemmed | Biosynthesis, characterization, and investigation of antimicrobial and cytotoxic activities of silver nanoparticles using Solanum tuberosum peel aqueous extract |
| title_short | Biosynthesis, characterization, and investigation of antimicrobial and cytotoxic activities of silver nanoparticles using Solanum tuberosum peel aqueous extract |
| title_sort | biosynthesis characterization and investigation of antimicrobial and cytotoxic activities of silver nanoparticles using solanum tuberosum peel aqueous extract |
| topic | Antimicrobial activity Cytotoxic activity Biogenic silver nanoparticles Solanum tuberosum L. Nanomedicine |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023062692 |
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