The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology
Natural products, including traditional herbal medicine (THM), are known to exert their therapeutic effects by acting on multiple targets, so researchers have employed network pharmacology methods to decipher the potential mechanisms of THM. To conduct THM-network pharmacology (THM-NP) studies, rese...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/9/8/362 |
| _version_ | 1818327908896210944 |
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| author | Won-Yung Lee Choong-Yeol Lee Youn-Sub Kim Chang-Eop Kim |
| author_facet | Won-Yung Lee Choong-Yeol Lee Youn-Sub Kim Chang-Eop Kim |
| author_sort | Won-Yung Lee |
| collection | DOAJ |
| description | Natural products, including traditional herbal medicine (THM), are known to exert their therapeutic effects by acting on multiple targets, so researchers have employed network pharmacology methods to decipher the potential mechanisms of THM. To conduct THM-network pharmacology (THM-NP) studies, researchers have employed different tools and databases for constructing and analyzing herb−compound−target networks. In this study, we attempted to capture the methodological trends in THM-NP research. We identified the tools and databases employed to conduct THM-NP studies and visualized their combinatorial patterns. We also constructed co-author and affiliation networks to further understand how the methodologies are employed among researchers. The results showed that the number of THM-NP studies and employed databases/tools have been dramatically increased in the last decade, and there are characteristic patterns in combining methods of each analysis step in THM-NP studies. Overall, the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was the most frequently employed network pharmacology database in THM-NP studies. Among the processes involved in THM-NP research, the methodology for constructing a compound−target network has shown the greatest change over time. In summary, our analysis describes comprehensive methodological trends and current ideas in research design for network pharmacology researchers. |
| first_indexed | 2024-12-13T12:23:45Z |
| format | Article |
| id | doaj.art-f8e16b4250d043469b93f196e521b821 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-12-13T12:23:45Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-f8e16b4250d043469b93f196e521b8212022-12-21T23:46:32ZengMDPI AGBiomolecules2218-273X2019-08-019836210.3390/biom9080362biom9080362The Methodological Trends of Traditional Herbal Medicine Employing Network PharmacologyWon-Yung Lee0Choong-Yeol Lee1Youn-Sub Kim2Chang-Eop Kim3Department of Physiology, College of Korean Medicine, Gachon University, Seongnam 13120, KoreaDepartment of Physiology, College of Korean Medicine, Gachon University, Seongnam 13120, KoreaDepartment of Anatomy-Pointology, College of Korean Medicine, Gachon University, Seongnam 13120, KoreaDepartment of Physiology, College of Korean Medicine, Gachon University, Seongnam 13120, KoreaNatural products, including traditional herbal medicine (THM), are known to exert their therapeutic effects by acting on multiple targets, so researchers have employed network pharmacology methods to decipher the potential mechanisms of THM. To conduct THM-network pharmacology (THM-NP) studies, researchers have employed different tools and databases for constructing and analyzing herb−compound−target networks. In this study, we attempted to capture the methodological trends in THM-NP research. We identified the tools and databases employed to conduct THM-NP studies and visualized their combinatorial patterns. We also constructed co-author and affiliation networks to further understand how the methodologies are employed among researchers. The results showed that the number of THM-NP studies and employed databases/tools have been dramatically increased in the last decade, and there are characteristic patterns in combining methods of each analysis step in THM-NP studies. Overall, the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was the most frequently employed network pharmacology database in THM-NP studies. Among the processes involved in THM-NP research, the methodology for constructing a compound−target network has shown the greatest change over time. In summary, our analysis describes comprehensive methodological trends and current ideas in research design for network pharmacology researchers.https://www.mdpi.com/2218-273X/9/8/362network pharmacologytraditional herbal medicinemethodological trend |
| spellingShingle | Won-Yung Lee Choong-Yeol Lee Youn-Sub Kim Chang-Eop Kim The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology Biomolecules network pharmacology traditional herbal medicine methodological trend |
| title | The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology |
| title_full | The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology |
| title_fullStr | The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology |
| title_full_unstemmed | The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology |
| title_short | The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology |
| title_sort | methodological trends of traditional herbal medicine employing network pharmacology |
| topic | network pharmacology traditional herbal medicine methodological trend |
| url | https://www.mdpi.com/2218-273X/9/8/362 |
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