Are lipid droplets the picnic basket of brain tumours?
Abstract Are lipid droplets (LDs) necessary to maintain the viability of brain tumour cells as they move to new nutrient-poor environments? In turn, could cancers be targeted by attacking what you might think of as the cancer cells’ picnic basket? Lipid metabolism reprogramming, represented by incre...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-01-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-024-01797-8 |
| _version_ | 1797350172840165376 |
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| author | Tanmayi Bingi Kian Cotton Charley Comer Maria Victoria Niklison-Chirou |
| author_facet | Tanmayi Bingi Kian Cotton Charley Comer Maria Victoria Niklison-Chirou |
| author_sort | Tanmayi Bingi |
| collection | DOAJ |
| description | Abstract Are lipid droplets (LDs) necessary to maintain the viability of brain tumour cells as they move to new nutrient-poor environments? In turn, could cancers be targeted by attacking what you might think of as the cancer cells’ picnic basket? Lipid metabolism reprogramming, represented by increased lipid uptake, activation of de novo lipogenesis and increased lipid storage, is a newly identified hallmark of cancers. Recently, the presence of lipid droplets has been detected in several types of cancers, such as metastatic hepatocellular carcinoma, pancreatic and breast. LDs are storage organelles that provide a source of nutrients which may drive metastasis in different tumours. Currently, several roles of LDs have been posited in various tumours. This perspective aims to review and discuss the currently understood role of LDs in brain tumours. |
| first_indexed | 2024-03-08T12:40:55Z |
| format | Article |
| id | doaj.art-f8e3d2951b3f42bda6a51c6f8b11fe2f |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-03-08T12:40:55Z |
| publishDate | 2024-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-f8e3d2951b3f42bda6a51c6f8b11fe2f2024-01-21T12:10:40ZengNature Publishing GroupCell Death Discovery2058-77162024-01-011011310.1038/s41420-024-01797-8Are lipid droplets the picnic basket of brain tumours?Tanmayi Bingi0Kian Cotton1Charley Comer2Maria Victoria Niklison-Chirou3Life Sciences Department, University of Bath, Claverton DownLife Sciences Department, University of Bath, Claverton DownLife Sciences Department, University of Bath, Claverton DownCentre for Therapeutic Innovation, Life Sciences Department, University of Bath, Claverton DownAbstract Are lipid droplets (LDs) necessary to maintain the viability of brain tumour cells as they move to new nutrient-poor environments? In turn, could cancers be targeted by attacking what you might think of as the cancer cells’ picnic basket? Lipid metabolism reprogramming, represented by increased lipid uptake, activation of de novo lipogenesis and increased lipid storage, is a newly identified hallmark of cancers. Recently, the presence of lipid droplets has been detected in several types of cancers, such as metastatic hepatocellular carcinoma, pancreatic and breast. LDs are storage organelles that provide a source of nutrients which may drive metastasis in different tumours. Currently, several roles of LDs have been posited in various tumours. This perspective aims to review and discuss the currently understood role of LDs in brain tumours.https://doi.org/10.1038/s41420-024-01797-8 |
| spellingShingle | Tanmayi Bingi Kian Cotton Charley Comer Maria Victoria Niklison-Chirou Are lipid droplets the picnic basket of brain tumours? Cell Death Discovery |
| title | Are lipid droplets the picnic basket of brain tumours? |
| title_full | Are lipid droplets the picnic basket of brain tumours? |
| title_fullStr | Are lipid droplets the picnic basket of brain tumours? |
| title_full_unstemmed | Are lipid droplets the picnic basket of brain tumours? |
| title_short | Are lipid droplets the picnic basket of brain tumours? |
| title_sort | are lipid droplets the picnic basket of brain tumours |
| url | https://doi.org/10.1038/s41420-024-01797-8 |
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