The Proteostasis Network: A Global Therapeutic Target for Neuroprotection after Spinal Cord Injury

The Proteostasis Network: A Global Therapeutic Target for Neuroprotection after Spinal Cord Injury

Proteostasis (protein homeostasis) is critical for cellular as well as organismal survival. It is strictly regulated by multiple conserved pathways including the ubiquitin-proteasome system, autophagy, the heat shock response, the integrated stress response, and the unfolded protein response. These...

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Bibliographic Details
Main Authors: Scott R. Whittemore, Sujata Saraswat Ohri, Michael D. Forston, George Z. Wei, Michal Hetman
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
spinal cord injury
neurotrauma
proteostasis
ER stress
neuroprotection
cell death
Online Access:https://www.mdpi.com/2073-4409/11/21/3339

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