The Potential Effects of Phytoestrogens: The Role in Neuroprotection
Phytoestrogens are naturally occurring non-steroidal phenolic plant compounds. Their structure is similar to 17-β-estradiol, the main female sex hormone. This review offers a concise summary of the current literature on several potential health benefits of phytoestrogens, mainly their neuroprotectiv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/10/2954 |
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| author | Justyna Gorzkiewicz Grzegorz Bartosz Izabela Sadowska-Bartosz |
| author_facet | Justyna Gorzkiewicz Grzegorz Bartosz Izabela Sadowska-Bartosz |
| author_sort | Justyna Gorzkiewicz |
| collection | DOAJ |
| description | Phytoestrogens are naturally occurring non-steroidal phenolic plant compounds. Their structure is similar to 17-β-estradiol, the main female sex hormone. This review offers a concise summary of the current literature on several potential health benefits of phytoestrogens, mainly their neuroprotective effect. Phytoestrogens lower the risk of menopausal symptoms and osteoporosis, as well as cardiovascular disease. They also reduce the risk of brain disease. The effects of phytoestrogens and their derivatives on cancer are mainly due to the inhibition of estrogen synthesis and metabolism, leading to antiangiogenic, antimetastatic, and epigenetic effects. The brain controls the secretion of estrogen (hypothalamus-pituitary-gonads axis). However, it has not been unequivocally established whether estrogen therapy has a neuroprotective effect on brain function. The neuroprotective effects of phytoestrogens seem to be related to both their antioxidant properties and interaction with the estrogen receptor. The possible effects of phytoestrogens on the thyroid cause some concern; nevertheless, generally, no serious side effects have been reported, and these compounds can be recommended as health-promoting food components or supplements. |
| first_indexed | 2024-03-10T11:22:31Z |
| format | Article |
| id | doaj.art-f8e701a160b94e69a03bb42af0ab124a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T11:22:31Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f8e701a160b94e69a03bb42af0ab124a2023-11-21T19:56:55ZengMDPI AGMolecules1420-30492021-05-012610295410.3390/molecules26102954The Potential Effects of Phytoestrogens: The Role in NeuroprotectionJustyna Gorzkiewicz0Grzegorz Bartosz1Izabela Sadowska-Bartosz2Laboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, Rzeszow University, 4 Zelwerowicza Street, 35-601 Rzeszow, PolandDepartment of Bioenergetics, Food Analysis and Microbiology, Institute of Food Technology and Nutrition, College of Natural Sciences, Rzeszow University, 4 Zelwerowicza Street, 35-601 Rzeszow, PolandLaboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, Rzeszow University, 4 Zelwerowicza Street, 35-601 Rzeszow, PolandPhytoestrogens are naturally occurring non-steroidal phenolic plant compounds. Their structure is similar to 17-β-estradiol, the main female sex hormone. This review offers a concise summary of the current literature on several potential health benefits of phytoestrogens, mainly their neuroprotective effect. Phytoestrogens lower the risk of menopausal symptoms and osteoporosis, as well as cardiovascular disease. They also reduce the risk of brain disease. The effects of phytoestrogens and their derivatives on cancer are mainly due to the inhibition of estrogen synthesis and metabolism, leading to antiangiogenic, antimetastatic, and epigenetic effects. The brain controls the secretion of estrogen (hypothalamus-pituitary-gonads axis). However, it has not been unequivocally established whether estrogen therapy has a neuroprotective effect on brain function. The neuroprotective effects of phytoestrogens seem to be related to both their antioxidant properties and interaction with the estrogen receptor. The possible effects of phytoestrogens on the thyroid cause some concern; nevertheless, generally, no serious side effects have been reported, and these compounds can be recommended as health-promoting food components or supplements.https://www.mdpi.com/1420-3049/26/10/2954phytoestrogensneuroprotective effectisoflavones |
| spellingShingle | Justyna Gorzkiewicz Grzegorz Bartosz Izabela Sadowska-Bartosz The Potential Effects of Phytoestrogens: The Role in Neuroprotection Molecules phytoestrogens neuroprotective effect isoflavones |
| title | The Potential Effects of Phytoestrogens: The Role in Neuroprotection |
| title_full | The Potential Effects of Phytoestrogens: The Role in Neuroprotection |
| title_fullStr | The Potential Effects of Phytoestrogens: The Role in Neuroprotection |
| title_full_unstemmed | The Potential Effects of Phytoestrogens: The Role in Neuroprotection |
| title_short | The Potential Effects of Phytoestrogens: The Role in Neuroprotection |
| title_sort | potential effects of phytoestrogens the role in neuroprotection |
| topic | phytoestrogens neuroprotective effect isoflavones |
| url | https://www.mdpi.com/1420-3049/26/10/2954 |
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