Protective effects and mechanism of curcumin in animal models of pulmonary fibrosis: a preclinical systematic review and meta-analysis
Introduction: At present, there is a lack of effective treatment for pulmonary fibrosis (PF), and a number of studies have confirmed that curcumin (CUR) has a good effect on PF.Research Qusetion: Is CUR effective in preclinical trials for PF and what is its mechanism of action?Methods: Animal report...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1258885/full |
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| author | Fang Hanyu Hong Zheng Wang Jiaqi Dong Tairan Zhao Yiyuanzi Yang Qiwen Liu Ying Zhang Hongchun Zhang Hongchun Liu Lu |
| author_facet | Fang Hanyu Hong Zheng Wang Jiaqi Dong Tairan Zhao Yiyuanzi Yang Qiwen Liu Ying Zhang Hongchun Zhang Hongchun Liu Lu |
| author_sort | Fang Hanyu |
| collection | DOAJ |
| description | Introduction: At present, there is a lack of effective treatment for pulmonary fibrosis (PF), and a number of studies have confirmed that curcumin (CUR) has a good effect on PF.Research Qusetion: Is CUR effective in preclinical trials for PF and what is its mechanism of action?Methods: Animal reports of PF treated with CUR were searched from Pubmed, Embase, Web of Science and Cochrane Library from 1 January 2000 to 19 April 2023 to compare CUR treatment of PF with a no-intervention model group. A previous registration (nsply registration number: INPLASY202360084) of this review protocol was undertaken.Results: The meta-analysis included 27 publications and 29 studies involving 396 animals. CUR significantly improved the degree of fibrosis, levels of inflammation, and oxidative imbalances in lung tissue in animal models of PF. In terms fibrosis, such as HYP content (SMD = −4.96; 95% CI = −6.05 to −3.87; p = 0.000).In terms of inflammatory indicators, such as MPO activity (SMD = −2.12; 95% CI = −4.93 to 0.69; p = 0.000). In terms of oxidation index, such as MDA (SMD = −5.63; 95% CI = −9.66 to −1.6; p = 0.000).Conclusion: CUR significantly improved the degree of fibrosis, levels of inflammation, and oxidative imbalances in lung tissue in animal models of PF. Due to the quantitative and qualitative limitations of current research, more high-quality studies are needed to verify the above conclusion. |
| first_indexed | 2024-03-11T18:33:27Z |
| format | Article |
| id | doaj.art-f8e83d35cfc9447299bc5892051422fb |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-11T18:33:27Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-f8e83d35cfc9447299bc5892051422fb2023-10-13T08:10:39ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-10-011410.3389/fphar.2023.12588851258885Protective effects and mechanism of curcumin in animal models of pulmonary fibrosis: a preclinical systematic review and meta-analysisFang Hanyu0Hong Zheng1Wang Jiaqi2Dong Tairan3Zhao Yiyuanzi4Yang Qiwen5Liu Ying6Zhang Hongchun7Zhang Hongchun8Liu Lu9Graduate School of Beijing University of Chinese Medicine, Beijing, ChinaGraduate School of Beijing University of Chinese Medicine, Beijing, ChinaDongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, ChinaGraduate School of Beijing University of Chinese Medicine, Beijing, ChinaDongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, ChinaDongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, ChinaThe Second Health and Medical Department, China-Japan Friendship Hospital, Beijing, ChinaGraduate School of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Traditional Chinese Medicine for Pulmonary Diseases, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Traditional Chinese Medicine for Pulmonary Diseases, Jining Hospital of Xiyuan Hospital of China Academy of Chinese Medical Science, Jining, Shandong, ChinaIntroduction: At present, there is a lack of effective treatment for pulmonary fibrosis (PF), and a number of studies have confirmed that curcumin (CUR) has a good effect on PF.Research Qusetion: Is CUR effective in preclinical trials for PF and what is its mechanism of action?Methods: Animal reports of PF treated with CUR were searched from Pubmed, Embase, Web of Science and Cochrane Library from 1 January 2000 to 19 April 2023 to compare CUR treatment of PF with a no-intervention model group. A previous registration (nsply registration number: INPLASY202360084) of this review protocol was undertaken.Results: The meta-analysis included 27 publications and 29 studies involving 396 animals. CUR significantly improved the degree of fibrosis, levels of inflammation, and oxidative imbalances in lung tissue in animal models of PF. In terms fibrosis, such as HYP content (SMD = −4.96; 95% CI = −6.05 to −3.87; p = 0.000).In terms of inflammatory indicators, such as MPO activity (SMD = −2.12; 95% CI = −4.93 to 0.69; p = 0.000). In terms of oxidation index, such as MDA (SMD = −5.63; 95% CI = −9.66 to −1.6; p = 0.000).Conclusion: CUR significantly improved the degree of fibrosis, levels of inflammation, and oxidative imbalances in lung tissue in animal models of PF. Due to the quantitative and qualitative limitations of current research, more high-quality studies are needed to verify the above conclusion.https://www.frontiersin.org/articles/10.3389/fphar.2023.1258885/fullpulmonary fibrosiscurcuminanimal modelspotential mechanismsmeta-analysis |
| spellingShingle | Fang Hanyu Hong Zheng Wang Jiaqi Dong Tairan Zhao Yiyuanzi Yang Qiwen Liu Ying Zhang Hongchun Zhang Hongchun Liu Lu Protective effects and mechanism of curcumin in animal models of pulmonary fibrosis: a preclinical systematic review and meta-analysis Frontiers in Pharmacology pulmonary fibrosis curcumin animal models potential mechanisms meta-analysis |
| title | Protective effects and mechanism of curcumin in animal models of pulmonary fibrosis: a preclinical systematic review and meta-analysis |
| title_full | Protective effects and mechanism of curcumin in animal models of pulmonary fibrosis: a preclinical systematic review and meta-analysis |
| title_fullStr | Protective effects and mechanism of curcumin in animal models of pulmonary fibrosis: a preclinical systematic review and meta-analysis |
| title_full_unstemmed | Protective effects and mechanism of curcumin in animal models of pulmonary fibrosis: a preclinical systematic review and meta-analysis |
| title_short | Protective effects and mechanism of curcumin in animal models of pulmonary fibrosis: a preclinical systematic review and meta-analysis |
| title_sort | protective effects and mechanism of curcumin in animal models of pulmonary fibrosis a preclinical systematic review and meta analysis |
| topic | pulmonary fibrosis curcumin animal models potential mechanisms meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1258885/full |
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