Histological chorioamnionitis and its impact on respiratory outcome in very-low-birth-weight preterm infants
Background: The role of intrauterine infection in the development of neonatal pulmonary disease is unclear and the impact of histological chorioamnionitis (HCAM) on respiratory outcomes in preterm infants remains controversial. The aim of this study was to explore the association between HCAM and ne...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-05-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957221000036 |
| _version_ | 1819292366212694016 |
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| author | Po-Chia Liu Yi-Li Hung Chung-Min Shen Pau-Chung Chen Wu-Shiun Hsieh |
| author_facet | Po-Chia Liu Yi-Li Hung Chung-Min Shen Pau-Chung Chen Wu-Shiun Hsieh |
| author_sort | Po-Chia Liu |
| collection | DOAJ |
| description | Background: The role of intrauterine infection in the development of neonatal pulmonary disease is unclear and the impact of histological chorioamnionitis (HCAM) on respiratory outcomes in preterm infants remains controversial. The aim of this study was to explore the association between HCAM and neonatal respiratory outcomes in very-low-birth-weight (VLBW) preterm infants and evaluate the stepwise difference in the stage and severity of HCAM among neonatal respiratory outcomes. Methods: We retrospectively enrolled 129 VLBW preterm infants with placenta histopathology examinations in this study. HCAM was subdivided into 3 stages (early, intermediate, and advanced) according to the progression of the maternal inflammatory response. The perinatal characteristics, placental histopathology, and neonatal morbidities, including respiratory outcomes (respiratory distress syndrome (RDS), Wilson-Mikity syndrome (WMS) and bronchopulmonary dysplasia (BPD)), were collected for comparison. Results: A total of 52.7% (68/129) of the infants had HCAM, including 23 early (stage 1), 30 intermediate (stage 2), and 15 advanced (stage 3) stage. There was no significant difference in the gestational age, birth body weight or mortality rate between the HCAM and non-HCAM groups. Mothers with HCAM had a significantly lower incidence of pre-eclampsia but a higher rate of premature rupture of membrane. They also had higher WBC counts and C-reactive protein levels before delivery. Neonates with HCAM had a lower incidence of RDS but were at a higher risk for developing WMS and BPD. After multivariate analysis adjustment, HCAM was still negatively associated with RDS (aOR = .069, p < .001) but without correlation with BPD. However, neonates with intermediate to advanced-stage HCAM had a higher risk of developing WMS and increased home oxygen usage rate compared to those with early-stage HCAM. Conclusion: HCAM has a protective effect from RDS in preterm neonates. Additionally, VLBW neonates with intermediate to advanced-stage HCAM are at risk for WMS. |
| first_indexed | 2024-12-24T03:53:23Z |
| format | Article |
| id | doaj.art-f8ea72d9ebf34647aefef72426ee73a1 |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-12-24T03:53:23Z |
| publishDate | 2021-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-f8ea72d9ebf34647aefef72426ee73a12022-12-21T17:16:31ZengElsevierPediatrics and Neonatology1875-95722021-05-01623258264Histological chorioamnionitis and its impact on respiratory outcome in very-low-birth-weight preterm infantsPo-Chia Liu0Yi-Li Hung1Chung-Min Shen2Pau-Chung Chen3Wu-Shiun Hsieh4Department of Pediatrics, Cathay General Hospital, Taipei, TaiwanDepartment of Pediatrics, Cathay General Hospital, Taipei, Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Department of Pediatrics, National Taiwan University Children's Hospital, Taipei, TaiwanDepartment of Pediatrics, Cathay General Hospital, Taipei, Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City, TaiwanInstitute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan; Taiwan University College of Public Health, Taipei, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, TaiwanDepartment of Pediatrics, Cathay General Hospital, Taipei, Taiwan; Department of Pediatrics, National Taiwan University Children's Hospital, Taipei, Taiwan; Department of Pediatrics, National Taiwan University College of Medicine, Taipei, Taiwan; Corresponding author. Department of Pediatrics, Cathay General Hospital, No. 280, Sec. 4, Ren Ai Road, Taipei 10630, Taiwan. Fax: +886 2 2314 7450.Background: The role of intrauterine infection in the development of neonatal pulmonary disease is unclear and the impact of histological chorioamnionitis (HCAM) on respiratory outcomes in preterm infants remains controversial. The aim of this study was to explore the association between HCAM and neonatal respiratory outcomes in very-low-birth-weight (VLBW) preterm infants and evaluate the stepwise difference in the stage and severity of HCAM among neonatal respiratory outcomes. Methods: We retrospectively enrolled 129 VLBW preterm infants with placenta histopathology examinations in this study. HCAM was subdivided into 3 stages (early, intermediate, and advanced) according to the progression of the maternal inflammatory response. The perinatal characteristics, placental histopathology, and neonatal morbidities, including respiratory outcomes (respiratory distress syndrome (RDS), Wilson-Mikity syndrome (WMS) and bronchopulmonary dysplasia (BPD)), were collected for comparison. Results: A total of 52.7% (68/129) of the infants had HCAM, including 23 early (stage 1), 30 intermediate (stage 2), and 15 advanced (stage 3) stage. There was no significant difference in the gestational age, birth body weight or mortality rate between the HCAM and non-HCAM groups. Mothers with HCAM had a significantly lower incidence of pre-eclampsia but a higher rate of premature rupture of membrane. They also had higher WBC counts and C-reactive protein levels before delivery. Neonates with HCAM had a lower incidence of RDS but were at a higher risk for developing WMS and BPD. After multivariate analysis adjustment, HCAM was still negatively associated with RDS (aOR = .069, p < .001) but without correlation with BPD. However, neonates with intermediate to advanced-stage HCAM had a higher risk of developing WMS and increased home oxygen usage rate compared to those with early-stage HCAM. Conclusion: HCAM has a protective effect from RDS in preterm neonates. Additionally, VLBW neonates with intermediate to advanced-stage HCAM are at risk for WMS.http://www.sciencedirect.com/science/article/pii/S1875957221000036bronchopulmonary dysplasiahistological chorioamnionitisrespiratory distress syndromevery-low-birth-weight infantsWilson-mikity syndrome |
| spellingShingle | Po-Chia Liu Yi-Li Hung Chung-Min Shen Pau-Chung Chen Wu-Shiun Hsieh Histological chorioamnionitis and its impact on respiratory outcome in very-low-birth-weight preterm infants Pediatrics and Neonatology bronchopulmonary dysplasia histological chorioamnionitis respiratory distress syndrome very-low-birth-weight infants Wilson-mikity syndrome |
| title | Histological chorioamnionitis and its impact on respiratory outcome in very-low-birth-weight preterm infants |
| title_full | Histological chorioamnionitis and its impact on respiratory outcome in very-low-birth-weight preterm infants |
| title_fullStr | Histological chorioamnionitis and its impact on respiratory outcome in very-low-birth-weight preterm infants |
| title_full_unstemmed | Histological chorioamnionitis and its impact on respiratory outcome in very-low-birth-weight preterm infants |
| title_short | Histological chorioamnionitis and its impact on respiratory outcome in very-low-birth-weight preterm infants |
| title_sort | histological chorioamnionitis and its impact on respiratory outcome in very low birth weight preterm infants |
| topic | bronchopulmonary dysplasia histological chorioamnionitis respiratory distress syndrome very-low-birth-weight infants Wilson-mikity syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S1875957221000036 |
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