Eugenol-Based Polymeric Materials—Antibacterial Activity and Applications
Eugenol (4-Allyl-2-methoxy phenol) (EUG) is a plant-derived allyl chain-substituted guaiacol, widely known for its antimicrobial and anesthetic properties, as well as the ability to scavenge reactive oxygen species. It is typically used as a mixture with zinc oxide (ZOE) for the preparation of resto...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/11/1570 |
| _version_ | 1797460437709619200 |
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| author | Anna Kowalewska Kamila Majewska-Smolarek |
| author_facet | Anna Kowalewska Kamila Majewska-Smolarek |
| author_sort | Anna Kowalewska |
| collection | DOAJ |
| description | Eugenol (4-Allyl-2-methoxy phenol) (EUG) is a plant-derived allyl chain-substituted guaiacol, widely known for its antimicrobial and anesthetic properties, as well as the ability to scavenge reactive oxygen species. It is typically used as a mixture with zinc oxide (ZOE) for the preparation of restorative tooth fillings and treatment of root canal infections. However, the high volatility of this insoluble-in-water component of natural essential oils can be an obstacle to its wider application. Moreover, molecular eugenol can be allergenic and even toxic if taken orally in high doses for long periods of time. Therefore, a growing interest in eugenol loading in polymeric materials (including the encapsulation of molecular eugenol and polymerization of EUG-derived monomers) has been noted recently. Such active macromolecular systems enhance the stability of eugenol action and potentially provide prolonged contact with pathogens without the undesired side effects of free EUG. In this review, we present an overview of methods leading to the formation of macromolecular derivatives of eugenol as well as the latest developments and further perspectives in their pharmacological and antimicrobial applications. |
| first_indexed | 2024-03-09T17:06:00Z |
| format | Article |
| id | doaj.art-f8ebb093f3d4484992cb38bde6bea92a |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T17:06:00Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-f8ebb093f3d4484992cb38bde6bea92a2023-11-24T14:25:09ZengMDPI AGAntibiotics2079-63822023-10-011211157010.3390/antibiotics12111570Eugenol-Based Polymeric Materials—Antibacterial Activity and ApplicationsAnna Kowalewska0Kamila Majewska-Smolarek1Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Łódź, PolandCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Łódź, PolandEugenol (4-Allyl-2-methoxy phenol) (EUG) is a plant-derived allyl chain-substituted guaiacol, widely known for its antimicrobial and anesthetic properties, as well as the ability to scavenge reactive oxygen species. It is typically used as a mixture with zinc oxide (ZOE) for the preparation of restorative tooth fillings and treatment of root canal infections. However, the high volatility of this insoluble-in-water component of natural essential oils can be an obstacle to its wider application. Moreover, molecular eugenol can be allergenic and even toxic if taken orally in high doses for long periods of time. Therefore, a growing interest in eugenol loading in polymeric materials (including the encapsulation of molecular eugenol and polymerization of EUG-derived monomers) has been noted recently. Such active macromolecular systems enhance the stability of eugenol action and potentially provide prolonged contact with pathogens without the undesired side effects of free EUG. In this review, we present an overview of methods leading to the formation of macromolecular derivatives of eugenol as well as the latest developments and further perspectives in their pharmacological and antimicrobial applications.https://www.mdpi.com/2079-6382/12/11/1570eugenolpolymeric materialsencapsulationantimicrobialcoatingsbiomedical applications |
| spellingShingle | Anna Kowalewska Kamila Majewska-Smolarek Eugenol-Based Polymeric Materials—Antibacterial Activity and Applications Antibiotics eugenol polymeric materials encapsulation antimicrobial coatings biomedical applications |
| title | Eugenol-Based Polymeric Materials—Antibacterial Activity and Applications |
| title_full | Eugenol-Based Polymeric Materials—Antibacterial Activity and Applications |
| title_fullStr | Eugenol-Based Polymeric Materials—Antibacterial Activity and Applications |
| title_full_unstemmed | Eugenol-Based Polymeric Materials—Antibacterial Activity and Applications |
| title_short | Eugenol-Based Polymeric Materials—Antibacterial Activity and Applications |
| title_sort | eugenol based polymeric materials antibacterial activity and applications |
| topic | eugenol polymeric materials encapsulation antimicrobial coatings biomedical applications |
| url | https://www.mdpi.com/2079-6382/12/11/1570 |
| work_keys_str_mv | AT annakowalewska eugenolbasedpolymericmaterialsantibacterialactivityandapplications AT kamilamajewskasmolarek eugenolbasedpolymericmaterialsantibacterialactivityandapplications |