Interstitial pulmonary fibrosis: The role of angiogenic factors, the inhibitory pathways of progression
AIM. To assess the role of angiogenic factors (vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) in interstitial lung diseases (ILD), such as fibrosing alveolitis, sarcoidosis. MATERIALS AND METHODS. The blood levels of endothelial dysfunction and neoangiogenesis markers (ET-1 and VE...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2014-08-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31533 |
| _version_ | 1818288215966089216 |
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| author | E N Popova M V Lebedeva A B PonomarEv I A Popova V V Fomin |
| author_facet | E N Popova M V Lebedeva A B PonomarEv I A Popova V V Fomin |
| author_sort | E N Popova |
| collection | DOAJ |
| description | AIM. To assess the role of angiogenic factors (vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) in interstitial lung diseases (ILD), such as fibrosing alveolitis, sarcoidosis. MATERIALS AND METHODS. The blood levels of endothelial dysfunction and neoangiogenesis markers (ET-1 and VEGF) were investigated in 96 patients with different clinical forms of ILD at it different stages; the found changes were compared with the clinical and morphological manifestations of the disease. RESULTS. It has been ascertained that regardless of the clinical type of ILD, there is a correlation between the blood levels of VEGF and ET-1 and the intensity of lung neoangiogenesis, the expression of VEGF by the endothelium of newly formed blood vessels, the production of angiogenic factors, the degree of endothelial dysfunction, the extent of pulmonary fibrosis, the degree of pulmonary vascular remodeling, and the severity of pulmonary hypertension. The findings suggest that the markers of neoangiogenesis play an important role in the mechanisms of ILD progression. CONCLUSION. The study of these parameters in the blood may be used to clarify the activity and prognosis of ILD. |
| first_indexed | 2024-12-13T01:52:51Z |
| format | Article |
| id | doaj.art-f8ed06e4c3cd4536a094ab91c8f0d6cf |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-13T01:52:51Z |
| publishDate | 2014-08-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-f8ed06e4c3cd4536a094ab91c8f0d6cf2022-12-22T00:03:28Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422014-08-01868232828549Interstitial pulmonary fibrosis: The role of angiogenic factors, the inhibitory pathways of progressionE N PopovaM V LebedevaA B PonomarEvI A PopovaV V FominAIM. To assess the role of angiogenic factors (vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) in interstitial lung diseases (ILD), such as fibrosing alveolitis, sarcoidosis. MATERIALS AND METHODS. The blood levels of endothelial dysfunction and neoangiogenesis markers (ET-1 and VEGF) were investigated in 96 patients with different clinical forms of ILD at it different stages; the found changes were compared with the clinical and morphological manifestations of the disease. RESULTS. It has been ascertained that regardless of the clinical type of ILD, there is a correlation between the blood levels of VEGF and ET-1 and the intensity of lung neoangiogenesis, the expression of VEGF by the endothelium of newly formed blood vessels, the production of angiogenic factors, the degree of endothelial dysfunction, the extent of pulmonary fibrosis, the degree of pulmonary vascular remodeling, and the severity of pulmonary hypertension. The findings suggest that the markers of neoangiogenesis play an important role in the mechanisms of ILD progression. CONCLUSION. The study of these parameters in the blood may be used to clarify the activity and prognosis of ILD.https://ter-arkhiv.ru/0040-3660/article/view/31533interstitial lung diseasesangiogenic factorsvascular endothelial growth factorendothelin-1pulmonary fibrosis |
| spellingShingle | E N Popova M V Lebedeva A B PonomarEv I A Popova V V Fomin Interstitial pulmonary fibrosis: The role of angiogenic factors, the inhibitory pathways of progression Терапевтический архив interstitial lung diseases angiogenic factors vascular endothelial growth factor endothelin-1 pulmonary fibrosis |
| title | Interstitial pulmonary fibrosis: The role of angiogenic factors, the inhibitory pathways of progression |
| title_full | Interstitial pulmonary fibrosis: The role of angiogenic factors, the inhibitory pathways of progression |
| title_fullStr | Interstitial pulmonary fibrosis: The role of angiogenic factors, the inhibitory pathways of progression |
| title_full_unstemmed | Interstitial pulmonary fibrosis: The role of angiogenic factors, the inhibitory pathways of progression |
| title_short | Interstitial pulmonary fibrosis: The role of angiogenic factors, the inhibitory pathways of progression |
| title_sort | interstitial pulmonary fibrosis the role of angiogenic factors the inhibitory pathways of progression |
| topic | interstitial lung diseases angiogenic factors vascular endothelial growth factor endothelin-1 pulmonary fibrosis |
| url | https://ter-arkhiv.ru/0040-3660/article/view/31533 |
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