IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling
Over the last decade, the E3-ubiquitine ligases from IAP (Inhibitor of Apoptosis) family have emerged as potent regulators of immune response. In immune cells, they control signaling pathways driving differentiation and inflammation in response to stimulation of tumor necrosis factor receptor (TNFR)...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/5/1118 |
| _version_ | 1827717765206638592 |
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| author | Baptiste Dumétier Aymeric Zadoroznyj Laurence Dubrez |
| author_facet | Baptiste Dumétier Aymeric Zadoroznyj Laurence Dubrez |
| author_sort | Baptiste Dumétier |
| collection | DOAJ |
| description | Over the last decade, the E3-ubiquitine ligases from IAP (Inhibitor of Apoptosis) family have emerged as potent regulators of immune response. In immune cells, they control signaling pathways driving differentiation and inflammation in response to stimulation of tumor necrosis factor receptor (TNFR) family, pattern-recognition receptors (PRRs), and some cytokine receptors. They are able to control the activity, the cellular fate, or the stability of actors of signaling pathways, acting at different levels from components of receptor-associated multiprotein complexes to signaling effectors and transcription factors, as well as cytoskeleton regulators. Much less is known about ubiquitination substrates involved in non-immune signaling pathways. This review aimed to present IAP ubiquitination substrates and the role of IAP-mediated ubiquitination in regulating signaling pathways. |
| first_indexed | 2024-03-10T20:08:01Z |
| format | Article |
| id | doaj.art-f8ee6e0c8b304a04b0dda72c9c5d0286 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T20:08:01Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-f8ee6e0c8b304a04b0dda72c9c5d02862023-11-19T23:09:19ZengMDPI AGCells2073-44092020-04-0195111810.3390/cells9051118IAP-Mediated Protein Ubiquitination in Regulating Cell SignalingBaptiste Dumétier0Aymeric Zadoroznyj1Laurence Dubrez2Institut National de la Santé et de la Recherche Médicale (Inserm), LNC UMR1231, 21000 Dijon, FranceInstitut National de la Santé et de la Recherche Médicale (Inserm), LNC UMR1231, 21000 Dijon, FranceInstitut National de la Santé et de la Recherche Médicale (Inserm), LNC UMR1231, 21000 Dijon, FranceOver the last decade, the E3-ubiquitine ligases from IAP (Inhibitor of Apoptosis) family have emerged as potent regulators of immune response. In immune cells, they control signaling pathways driving differentiation and inflammation in response to stimulation of tumor necrosis factor receptor (TNFR) family, pattern-recognition receptors (PRRs), and some cytokine receptors. They are able to control the activity, the cellular fate, or the stability of actors of signaling pathways, acting at different levels from components of receptor-associated multiprotein complexes to signaling effectors and transcription factors, as well as cytoskeleton regulators. Much less is known about ubiquitination substrates involved in non-immune signaling pathways. This review aimed to present IAP ubiquitination substrates and the role of IAP-mediated ubiquitination in regulating signaling pathways.https://www.mdpi.com/2073-4409/9/5/1118IAPubiquitinationcell signalinginflammation |
| spellingShingle | Baptiste Dumétier Aymeric Zadoroznyj Laurence Dubrez IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling Cells IAP ubiquitination cell signaling inflammation |
| title | IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling |
| title_full | IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling |
| title_fullStr | IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling |
| title_full_unstemmed | IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling |
| title_short | IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling |
| title_sort | iap mediated protein ubiquitination in regulating cell signaling |
| topic | IAP ubiquitination cell signaling inflammation |
| url | https://www.mdpi.com/2073-4409/9/5/1118 |
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