Synergistic Effects and Mechanisms of Budesonide in Combination with Fluconazole against Resistant Candida albicans.
Candida albicans is an important opportunistic pathogen, causing both superficial mucosal infections and life-threatening systemic diseases in the clinic. The emergence of drug resistance in Candida albicans has become a noteworthy phenomenon due to the extensive use of antifungal agents and the dev...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5179115?pdf=render |
| _version_ | 1819110493783064576 |
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| author | Xiuyun Li Cuixiang Yu Xin Huang Shujuan Sun |
| author_facet | Xiuyun Li Cuixiang Yu Xin Huang Shujuan Sun |
| author_sort | Xiuyun Li |
| collection | DOAJ |
| description | Candida albicans is an important opportunistic pathogen, causing both superficial mucosal infections and life-threatening systemic diseases in the clinic. The emergence of drug resistance in Candida albicans has become a noteworthy phenomenon due to the extensive use of antifungal agents and the development of biofilms. This study showed that budesonide potentiates the antifungal effect of fluconazole against fluconazole-resistant Candida albicans strains both in vitro and in vivo. In addition, our results demonstrated, for the first time, that the combination of fluconazole and budesonide can reverse the resistance of Candida albicans by inhibiting the function of drug transporters, reducing the formation of biofilms, promoting apoptosis and inhibiting the activity of extracellular phospholipases. This is the first study implicating the effects and mechanisms of budesonide against Candida albicans alone or in combination with fluconazole, which may ultimately lead to the identification of new potential antifungal targets. |
| first_indexed | 2024-12-22T03:42:36Z |
| format | Article |
| id | doaj.art-f8eeda1d14de4a8989505b9420e71125 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T03:42:36Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-f8eeda1d14de4a8989505b9420e711252022-12-21T18:40:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011112e016893610.1371/journal.pone.0168936Synergistic Effects and Mechanisms of Budesonide in Combination with Fluconazole against Resistant Candida albicans.Xiuyun LiCuixiang YuXin HuangShujuan SunCandida albicans is an important opportunistic pathogen, causing both superficial mucosal infections and life-threatening systemic diseases in the clinic. The emergence of drug resistance in Candida albicans has become a noteworthy phenomenon due to the extensive use of antifungal agents and the development of biofilms. This study showed that budesonide potentiates the antifungal effect of fluconazole against fluconazole-resistant Candida albicans strains both in vitro and in vivo. In addition, our results demonstrated, for the first time, that the combination of fluconazole and budesonide can reverse the resistance of Candida albicans by inhibiting the function of drug transporters, reducing the formation of biofilms, promoting apoptosis and inhibiting the activity of extracellular phospholipases. This is the first study implicating the effects and mechanisms of budesonide against Candida albicans alone or in combination with fluconazole, which may ultimately lead to the identification of new potential antifungal targets.http://europepmc.org/articles/PMC5179115?pdf=render |
| spellingShingle | Xiuyun Li Cuixiang Yu Xin Huang Shujuan Sun Synergistic Effects and Mechanisms of Budesonide in Combination with Fluconazole against Resistant Candida albicans. PLoS ONE |
| title | Synergistic Effects and Mechanisms of Budesonide in Combination with Fluconazole against Resistant Candida albicans. |
| title_full | Synergistic Effects and Mechanisms of Budesonide in Combination with Fluconazole against Resistant Candida albicans. |
| title_fullStr | Synergistic Effects and Mechanisms of Budesonide in Combination with Fluconazole against Resistant Candida albicans. |
| title_full_unstemmed | Synergistic Effects and Mechanisms of Budesonide in Combination with Fluconazole against Resistant Candida albicans. |
| title_short | Synergistic Effects and Mechanisms of Budesonide in Combination with Fluconazole against Resistant Candida albicans. |
| title_sort | synergistic effects and mechanisms of budesonide in combination with fluconazole against resistant candida albicans |
| url | http://europepmc.org/articles/PMC5179115?pdf=render |
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