Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections
Actin filaments, microtubules and intermediate filaments form the cytoskeleton of vertebrate cells. Involved in maintaining cell integrity and structure, facilitating cargo and vesicle transport, remodelling surface structures and motility, the cytoskeleton is necessary for the successful life of a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-02-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/10/2/79 |
| _version_ | 1828483771739930624 |
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| author | Christopher E. Denes Monica Miranda-Saksena Anthony L. Cunningham Russell J. Diefenbach |
| author_facet | Christopher E. Denes Monica Miranda-Saksena Anthony L. Cunningham Russell J. Diefenbach |
| author_sort | Christopher E. Denes |
| collection | DOAJ |
| description | Actin filaments, microtubules and intermediate filaments form the cytoskeleton of vertebrate cells. Involved in maintaining cell integrity and structure, facilitating cargo and vesicle transport, remodelling surface structures and motility, the cytoskeleton is necessary for the successful life of a cell. Because of the broad range of functions these filaments are involved in, they are common targets for viral pathogens, including the alphaherpesviruses. Human-tropic alphaherpesviruses are prevalent pathogens carried by more than half of the world’s population; comprising herpes simplex virus (types 1 and 2) and varicella-zoster virus, these viruses are characterised by their ability to establish latency in sensory neurons. This review will discuss the known mechanisms involved in subversion of and transport via the cytoskeleton during alphaherpesvirus infections, focusing on protein-protein interactions and pathways that have recently been identified. Studies on related alphaherpesviruses whose primary host is not human, along with comparisons to more distantly related beta and gammaherpesviruses, are also presented in this review. The need to decipher as-yet-unknown mechanisms exploited by viruses to hijack cytoskeletal components—to reveal the hidden cytoskeletons in the closet—will also be addressed. |
| first_indexed | 2024-12-11T08:43:41Z |
| format | Article |
| id | doaj.art-f8f0524d63724c328f37aa10e254f0dd |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-11T08:43:41Z |
| publishDate | 2018-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-f8f0524d63724c328f37aa10e254f0dd2022-12-22T01:14:12ZengMDPI AGViruses1999-49152018-02-011027910.3390/v10020079v10020079Cytoskeletons in the Closet—Subversion in Alphaherpesvirus InfectionsChristopher E. Denes0Monica Miranda-Saksena1Anthony L. Cunningham2Russell J. Diefenbach3Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, AustraliaCentre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, AustraliaCentre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, AustraliaCentre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, AustraliaActin filaments, microtubules and intermediate filaments form the cytoskeleton of vertebrate cells. Involved in maintaining cell integrity and structure, facilitating cargo and vesicle transport, remodelling surface structures and motility, the cytoskeleton is necessary for the successful life of a cell. Because of the broad range of functions these filaments are involved in, they are common targets for viral pathogens, including the alphaherpesviruses. Human-tropic alphaherpesviruses are prevalent pathogens carried by more than half of the world’s population; comprising herpes simplex virus (types 1 and 2) and varicella-zoster virus, these viruses are characterised by their ability to establish latency in sensory neurons. This review will discuss the known mechanisms involved in subversion of and transport via the cytoskeleton during alphaherpesvirus infections, focusing on protein-protein interactions and pathways that have recently been identified. Studies on related alphaherpesviruses whose primary host is not human, along with comparisons to more distantly related beta and gammaherpesviruses, are also presented in this review. The need to decipher as-yet-unknown mechanisms exploited by viruses to hijack cytoskeletal components—to reveal the hidden cytoskeletons in the closet—will also be addressed.http://www.mdpi.com/1999-4915/10/2/79alphaherpesviruscytoskeletonactinmicrotubulesintermediate filamentsherpes simplex virusvirus transport |
| spellingShingle | Christopher E. Denes Monica Miranda-Saksena Anthony L. Cunningham Russell J. Diefenbach Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections Viruses alphaherpesvirus cytoskeleton actin microtubules intermediate filaments herpes simplex virus virus transport |
| title | Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections |
| title_full | Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections |
| title_fullStr | Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections |
| title_full_unstemmed | Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections |
| title_short | Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections |
| title_sort | cytoskeletons in the closet subversion in alphaherpesvirus infections |
| topic | alphaherpesvirus cytoskeleton actin microtubules intermediate filaments herpes simplex virus virus transport |
| url | http://www.mdpi.com/1999-4915/10/2/79 |
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