Cholestatic hepatitis: atypical presentation of Epstein-Barr virus infection
Epstein-Barr virus (EBV) primary infection frequently leads to a mild and self-limited increase in liver enzymes. However, clinical manifestations of hepatitis including jaundice are very rare in children. We report a case of an 11-year-old female with fever, vomiting, abdominal pain, jaundice and c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Hygeia Press di Corridori Marinella
2018-01-01
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| Series: | Journal of Pediatric and Neonatal Individualized Medicine |
| Subjects: | |
| Online Access: | https://www.jpnim.com/index.php/jpnim/article/view/506 |
| _version_ | 1819089427010420736 |
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| author | Carolina Guimarães Raquel Garrido Margarida Chaves Sara Martins |
| author_facet | Carolina Guimarães Raquel Garrido Margarida Chaves Sara Martins |
| author_sort | Carolina Guimarães |
| collection | DOAJ |
| description | Epstein-Barr virus (EBV) primary infection frequently leads to a mild and self-limited increase in liver enzymes. However, clinical manifestations of hepatitis including jaundice are very rare in children. We report a case of an 11-year-old female with fever, vomiting, abdominal pain, jaundice and choluria. The physical examination showed jaundice, cervical adenopathy and mild hepatomegaly. She later developed tonsillitis and a rash. Laboratorial evaluation revealed atypical lymphocytosis (19.3%), increased aspartate aminotransferase 371 IU/L, alanine aminotransferase 373 IU/L and γ-glutamyl transpeptidase 110 IU/L, hyperbilirubinaemia (total bilirubin 14.83 mg/dL, direct bilirubin 11.39 mg/dL), bilirubinuria and hypoalbuminaemia (minimum 2.4 g/dL). The anti-EBV viral capsid antibodies IgM and IgG were positive. Other viral serologies were negative and the abdominal ultrasound was normal. EBV first infection should be considered in the differential diagnosis of cholestatic hepatitis in children. |
| first_indexed | 2024-12-21T22:07:45Z |
| format | Article |
| id | doaj.art-f8f4a16a20914722bc2c24e8386505a7 |
| institution | Directory Open Access Journal |
| issn | 2281-0692 |
| language | English |
| last_indexed | 2024-12-21T22:07:45Z |
| publishDate | 2018-01-01 |
| publisher | Hygeia Press di Corridori Marinella |
| record_format | Article |
| series | Journal of Pediatric and Neonatal Individualized Medicine |
| spelling | doaj.art-f8f4a16a20914722bc2c24e8386505a72022-12-21T18:48:40ZengHygeia Press di Corridori MarinellaJournal of Pediatric and Neonatal Individualized Medicine2281-06922018-01-0171e070118e07011810.7363/070118424Cholestatic hepatitis: atypical presentation of Epstein-Barr virus infectionCarolina Guimarães0Raquel Garrido1Margarida Chaves2Sara Martins3Division of Pediatrics, Hospital de Cascais, Cascais, PortugalDivision of Pediatrics, Hospital de Cascais, Cascais, PortugalDivision of Pediatrics, Hospital de Cascais, Cascais, PortugalDivision of Pediatrics, Hospital de Cascais, Cascais, PortugalEpstein-Barr virus (EBV) primary infection frequently leads to a mild and self-limited increase in liver enzymes. However, clinical manifestations of hepatitis including jaundice are very rare in children. We report a case of an 11-year-old female with fever, vomiting, abdominal pain, jaundice and choluria. The physical examination showed jaundice, cervical adenopathy and mild hepatomegaly. She later developed tonsillitis and a rash. Laboratorial evaluation revealed atypical lymphocytosis (19.3%), increased aspartate aminotransferase 371 IU/L, alanine aminotransferase 373 IU/L and γ-glutamyl transpeptidase 110 IU/L, hyperbilirubinaemia (total bilirubin 14.83 mg/dL, direct bilirubin 11.39 mg/dL), bilirubinuria and hypoalbuminaemia (minimum 2.4 g/dL). The anti-EBV viral capsid antibodies IgM and IgG were positive. Other viral serologies were negative and the abdominal ultrasound was normal. EBV first infection should be considered in the differential diagnosis of cholestatic hepatitis in children.https://www.jpnim.com/index.php/jpnim/article/view/506hepatitischolestasisepstein-barr virus |
| spellingShingle | Carolina Guimarães Raquel Garrido Margarida Chaves Sara Martins Cholestatic hepatitis: atypical presentation of Epstein-Barr virus infection Journal of Pediatric and Neonatal Individualized Medicine hepatitis cholestasis epstein-barr virus |
| title | Cholestatic hepatitis: atypical presentation of Epstein-Barr virus infection |
| title_full | Cholestatic hepatitis: atypical presentation of Epstein-Barr virus infection |
| title_fullStr | Cholestatic hepatitis: atypical presentation of Epstein-Barr virus infection |
| title_full_unstemmed | Cholestatic hepatitis: atypical presentation of Epstein-Barr virus infection |
| title_short | Cholestatic hepatitis: atypical presentation of Epstein-Barr virus infection |
| title_sort | cholestatic hepatitis atypical presentation of epstein barr virus infection |
| topic | hepatitis cholestasis epstein-barr virus |
| url | https://www.jpnim.com/index.php/jpnim/article/view/506 |
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