Long Non-Coding RNA Associated with Cholesterol Homeostasis and Its Involvement in Metabolic Diseases
Cholesterol is an essential cell component that functions to create and maintain all kinds of cell membranes and lipoprotein particles. It is crucial to maintain the proper amount of cholesterol at both the cellular and systemic level. Recently, the importance of cholesterol has been reported not on...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/21/8337 |
| _version_ | 1797548650410278912 |
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| author | Kang-Hoon Lee Hyeon-Ji Hwang Je-Yoel Cho |
| author_facet | Kang-Hoon Lee Hyeon-Ji Hwang Je-Yoel Cho |
| author_sort | Kang-Hoon Lee |
| collection | DOAJ |
| description | Cholesterol is an essential cell component that functions to create and maintain all kinds of cell membranes and lipoprotein particles. It is crucial to maintain the proper amount of cholesterol at both the cellular and systemic level. Recently, the importance of cholesterol has been reported not only in various cell development processes but also in the development of diseases. Furthermore, the involvement of long non-coding RNAs (lncRNAs), which are regarded as important epigenetic regulators in gene expression, has also been reported in cholesterol homeostasis. It is thus necessary to summarize the research on lncRNAs related to cholesterol with increased interest. This review organized the role of lncRNAs according to the major issues in cholesterol homeostasis: efflux, metabolism and synthesis, and disease process. |
| first_indexed | 2024-03-10T15:03:40Z |
| format | Article |
| id | doaj.art-f8f74dcb98fc4be8ade09642d1ec67db |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:03:40Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f8f74dcb98fc4be8ade09642d1ec67db2023-11-20T20:02:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012121833710.3390/ijms21218337Long Non-Coding RNA Associated with Cholesterol Homeostasis and Its Involvement in Metabolic DiseasesKang-Hoon Lee0Hyeon-Ji Hwang1Je-Yoel Cho2Department of Biochemistry, BK21 Plus and Research Institute for Veterinary Science, School of Veterinary Medicine, Seoul National University, Seoul 08826, KoreaDepartment of Biochemistry, BK21 Plus and Research Institute for Veterinary Science, School of Veterinary Medicine, Seoul National University, Seoul 08826, KoreaDepartment of Biochemistry, BK21 Plus and Research Institute for Veterinary Science, School of Veterinary Medicine, Seoul National University, Seoul 08826, KoreaCholesterol is an essential cell component that functions to create and maintain all kinds of cell membranes and lipoprotein particles. It is crucial to maintain the proper amount of cholesterol at both the cellular and systemic level. Recently, the importance of cholesterol has been reported not only in various cell development processes but also in the development of diseases. Furthermore, the involvement of long non-coding RNAs (lncRNAs), which are regarded as important epigenetic regulators in gene expression, has also been reported in cholesterol homeostasis. It is thus necessary to summarize the research on lncRNAs related to cholesterol with increased interest. This review organized the role of lncRNAs according to the major issues in cholesterol homeostasis: efflux, metabolism and synthesis, and disease process.https://www.mdpi.com/1422-0067/21/21/8337long non-coding RNAlncRNAcholesteroldisease |
| spellingShingle | Kang-Hoon Lee Hyeon-Ji Hwang Je-Yoel Cho Long Non-Coding RNA Associated with Cholesterol Homeostasis and Its Involvement in Metabolic Diseases International Journal of Molecular Sciences long non-coding RNA lncRNA cholesterol disease |
| title | Long Non-Coding RNA Associated with Cholesterol Homeostasis and Its Involvement in Metabolic Diseases |
| title_full | Long Non-Coding RNA Associated with Cholesterol Homeostasis and Its Involvement in Metabolic Diseases |
| title_fullStr | Long Non-Coding RNA Associated with Cholesterol Homeostasis and Its Involvement in Metabolic Diseases |
| title_full_unstemmed | Long Non-Coding RNA Associated with Cholesterol Homeostasis and Its Involvement in Metabolic Diseases |
| title_short | Long Non-Coding RNA Associated with Cholesterol Homeostasis and Its Involvement in Metabolic Diseases |
| title_sort | long non coding rna associated with cholesterol homeostasis and its involvement in metabolic diseases |
| topic | long non-coding RNA lncRNA cholesterol disease |
| url | https://www.mdpi.com/1422-0067/21/21/8337 |
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