Antimicrobial and Antioxidant Properties of Chemically Analyzed Essential Oil of <i>Artemisia annua</i> L. (Asteraceae) Native to Mediterranean Area
<i>Artemisia annua</i> (AA) is an aromatic plant belonging to the <i>Asteraceae</i> family, which has long been known for its several medicinal virtues. In addition, essential oils (EOs) extracted from AA have a wide range of therapeutic properties. Therefore, this study aime...
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MDPI AG
2023-03-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/3/807 |
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| author | Khalid Chebbac Zineb Benziane Ouaritini Abdelfattah El Moussaoui Mohammed Chalkha Soufyane Lafraxo Yousef A. Bin Jardan Hiba-Allah Nafidi Mohammed Bourhia Raja Guemmouh |
| author_facet | Khalid Chebbac Zineb Benziane Ouaritini Abdelfattah El Moussaoui Mohammed Chalkha Soufyane Lafraxo Yousef A. Bin Jardan Hiba-Allah Nafidi Mohammed Bourhia Raja Guemmouh |
| author_sort | Khalid Chebbac |
| collection | DOAJ |
| description | <i>Artemisia annua</i> (AA) is an aromatic plant belonging to the <i>Asteraceae</i> family, which has long been known for its several medicinal virtues. In addition, essential oils (EOs) extracted from AA have a wide range of therapeutic properties. Therefore, this study aimed to investigate the phytochemical composition, anti-microbial, and anti-oxidant properties of <i>Artemisia annua</i> essential oil (EOAA). EO was extracted, and its chemical constituents were ascertained by the use of GC-MS analysis. EOAA shows remarkable antioxidant capacities of DPPH free radical scavenging with an IC<sub>50</sub> value of 29 ± 5.3 μg/mL and ferric reducing antioxidant power with an EC<sub>50</sub> value of 9.21 ± 0.3 µg/mL, and it also has a good total antioxidant capacity of 911.59 ± 115.71 milligrams of ascorbic acid equivalence per gram of EO (mg AAE/g EO). Moreover, the in vitro antimicrobial screening results indicate that EOAA has shown promising antibacterial activity, especially against the <i>Escherichia coli</i> strain, and it also shows significant antifungal activity against <i>Fusarium oxysporum</i> and <i>Candida albicans</i> yeasts. Taken together, our findings highlight the importance of EOAA as a source of strong antioxidant and antimicrobial agents, which could be used as an alternative form to control free radicals and combat drug-resistant microbes. |
| first_indexed | 2024-03-11T06:17:47Z |
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| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T06:17:47Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-f8f7969cd8474817b944269818aa8ee92023-11-17T12:12:38ZengMDPI AGLife2075-17292023-03-0113380710.3390/life13030807Antimicrobial and Antioxidant Properties of Chemically Analyzed Essential Oil of <i>Artemisia annua</i> L. (Asteraceae) Native to Mediterranean AreaKhalid Chebbac0Zineb Benziane Ouaritini1Abdelfattah El Moussaoui2Mohammed Chalkha3Soufyane Lafraxo4Yousef A. Bin Jardan5Hiba-Allah Nafidi6Mohammed Bourhia7Raja Guemmouh8Laboratory of Biotechnology Conservation and Valorisation of Natural Resources, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez 30000, MoroccoLaboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life, Faculty of Sciences, Sidi Mohamed Ben Abdellah University, Fez 30000, MoroccoLaboratory of Biotechnology, Environment, Agri-Food and Health, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez 30000, MoroccoEngineering Laboratory of Organometallic, Molecular, Materials and Environment, Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University, Fez 30000, MoroccoLaboratory of Biotechnology, Environment, Agri-Food and Health, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez 30000, MoroccoDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Food Science, Faculty of Agricultural and Food Sciences, Laval University, Quebec City, QC G1V 0A6, CanadaLaboratory of Chemistry and Biochemistry, Faculty of Medicine and Pharmacy, Laayoune 70000, MoroccoLaboratory of Biotechnology Conservation and Valorisation of Natural Resources, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco<i>Artemisia annua</i> (AA) is an aromatic plant belonging to the <i>Asteraceae</i> family, which has long been known for its several medicinal virtues. In addition, essential oils (EOs) extracted from AA have a wide range of therapeutic properties. Therefore, this study aimed to investigate the phytochemical composition, anti-microbial, and anti-oxidant properties of <i>Artemisia annua</i> essential oil (EOAA). EO was extracted, and its chemical constituents were ascertained by the use of GC-MS analysis. EOAA shows remarkable antioxidant capacities of DPPH free radical scavenging with an IC<sub>50</sub> value of 29 ± 5.3 μg/mL and ferric reducing antioxidant power with an EC<sub>50</sub> value of 9.21 ± 0.3 µg/mL, and it also has a good total antioxidant capacity of 911.59 ± 115.71 milligrams of ascorbic acid equivalence per gram of EO (mg AAE/g EO). Moreover, the in vitro antimicrobial screening results indicate that EOAA has shown promising antibacterial activity, especially against the <i>Escherichia coli</i> strain, and it also shows significant antifungal activity against <i>Fusarium oxysporum</i> and <i>Candida albicans</i> yeasts. Taken together, our findings highlight the importance of EOAA as a source of strong antioxidant and antimicrobial agents, which could be used as an alternative form to control free radicals and combat drug-resistant microbes.https://www.mdpi.com/2075-1729/13/3/807<i>Artemisia annua</i> L. (Asteraceae)essential oilchemical constituentsantimicrobial activityantioxidant capacity |
| spellingShingle | Khalid Chebbac Zineb Benziane Ouaritini Abdelfattah El Moussaoui Mohammed Chalkha Soufyane Lafraxo Yousef A. Bin Jardan Hiba-Allah Nafidi Mohammed Bourhia Raja Guemmouh Antimicrobial and Antioxidant Properties of Chemically Analyzed Essential Oil of <i>Artemisia annua</i> L. (Asteraceae) Native to Mediterranean Area Life <i>Artemisia annua</i> L. (Asteraceae) essential oil chemical constituents antimicrobial activity antioxidant capacity |
| title | Antimicrobial and Antioxidant Properties of Chemically Analyzed Essential Oil of <i>Artemisia annua</i> L. (Asteraceae) Native to Mediterranean Area |
| title_full | Antimicrobial and Antioxidant Properties of Chemically Analyzed Essential Oil of <i>Artemisia annua</i> L. (Asteraceae) Native to Mediterranean Area |
| title_fullStr | Antimicrobial and Antioxidant Properties of Chemically Analyzed Essential Oil of <i>Artemisia annua</i> L. (Asteraceae) Native to Mediterranean Area |
| title_full_unstemmed | Antimicrobial and Antioxidant Properties of Chemically Analyzed Essential Oil of <i>Artemisia annua</i> L. (Asteraceae) Native to Mediterranean Area |
| title_short | Antimicrobial and Antioxidant Properties of Chemically Analyzed Essential Oil of <i>Artemisia annua</i> L. (Asteraceae) Native to Mediterranean Area |
| title_sort | antimicrobial and antioxidant properties of chemically analyzed essential oil of i artemisia annua i l asteraceae native to mediterranean area |
| topic | <i>Artemisia annua</i> L. (Asteraceae) essential oil chemical constituents antimicrobial activity antioxidant capacity |
| url | https://www.mdpi.com/2075-1729/13/3/807 |
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