Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson’s disease
By controlling the proper folding of proteins imported into mitochondria and ensuring crosstalk between the reticulum and mitochondria to modulate intracellular calcium fluxes, Mortalin is a chaperone protein that plays crucial roles in neuronal homeostasis and activity. However, its expression and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=2;spage=293;epage=298;aulast= |
| _version_ | 1811309649395187712 |
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| author | Baptiste Texier Morgane Prime Djamaa Atamena Pascale Belenguer Marion Szelechowski |
| author_facet | Baptiste Texier Morgane Prime Djamaa Atamena Pascale Belenguer Marion Szelechowski |
| author_sort | Baptiste Texier |
| collection | DOAJ |
| description | By controlling the proper folding of proteins imported into mitochondria and ensuring crosstalk between the reticulum and mitochondria to modulate intracellular calcium fluxes, Mortalin is a chaperone protein that plays crucial roles in neuronal homeostasis and activity. However, its expression and stability are strongly modified in response to cellular stresses, in particular upon altered oxidative conditions during neurodegeneration. Here, we report and discuss the abundant literature that has highlighted its contribution to the pathophysiology of Parkinson’s disease, as well as its therapeutic and prognostic potential in this still incurable pathology. |
| first_indexed | 2024-04-13T09:45:12Z |
| format | Article |
| id | doaj.art-f8fa3bceadc94b73b333b11cbbb207f3 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-13T09:45:12Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-f8fa3bceadc94b73b333b11cbbb207f32022-12-22T02:51:47ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742023-01-0118229329810.4103/1673-5374.346487Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson’s diseaseBaptiste TexierMorgane PrimeDjamaa AtamenaPascale BelenguerMarion SzelechowskiBy controlling the proper folding of proteins imported into mitochondria and ensuring crosstalk between the reticulum and mitochondria to modulate intracellular calcium fluxes, Mortalin is a chaperone protein that plays crucial roles in neuronal homeostasis and activity. However, its expression and stability are strongly modified in response to cellular stresses, in particular upon altered oxidative conditions during neurodegeneration. Here, we report and discuss the abundant literature that has highlighted its contribution to the pathophysiology of Parkinson’s disease, as well as its therapeutic and prognostic potential in this still incurable pathology.http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=2;spage=293;epage=298;aulast=chaperone; hspa9; mitochondria; mortalin; neurodegeneration; oxidative stress; parkinson’s disease; prognostic and therapeutic potential |
| spellingShingle | Baptiste Texier Morgane Prime Djamaa Atamena Pascale Belenguer Marion Szelechowski Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson’s disease Neural Regeneration Research chaperone; hspa9; mitochondria; mortalin; neurodegeneration; oxidative stress; parkinson’s disease; prognostic and therapeutic potential |
| title | Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson’s disease |
| title_full | Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson’s disease |
| title_fullStr | Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson’s disease |
| title_full_unstemmed | Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson’s disease |
| title_short | Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson’s disease |
| title_sort | mortalin hspa9 involvement and therapeutic perspective in parkinson s disease |
| topic | chaperone; hspa9; mitochondria; mortalin; neurodegeneration; oxidative stress; parkinson’s disease; prognostic and therapeutic potential |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=2;spage=293;epage=298;aulast= |
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