Association between previous surgical termination of pregnancy and pregnancy outcomes in frozen-thawed embryo transfer cycles of IVF/ICSI: a retrospective cohort study
Abstract This study aimed to evaluate the effect of previous surgical termination of pregnancy (STP) on pregnancy outcomes in women undergoing FET cycles of IVF/ICSI. Retrospective cohort study. Reproductive Center of Maternal and Child Health Care Hospital in Lianyungang city. Data were selected fr...
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Nature Portfolio
2024-03-01
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| Online Access: | https://doi.org/10.1038/s41598-024-57377-4 |
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| author | Shuai Zhang Hanhan Tang Minglian Zhou |
| author_facet | Shuai Zhang Hanhan Tang Minglian Zhou |
| author_sort | Shuai Zhang |
| collection | DOAJ |
| description | Abstract This study aimed to evaluate the effect of previous surgical termination of pregnancy (STP) on pregnancy outcomes in women undergoing FET cycles of IVF/ICSI. Retrospective cohort study. Reproductive Center of Maternal and Child Health Care Hospital in Lianyungang city. Data were selected from all IVF/ICSI FET cycles performed between January 2014 and December 2020. A total of 761 cycles met the criteria were included in this study. The primary outcome measures were clinical pregnancy and live birth rates. Secondary outcome measures were biochemical pregnancy rate, spontaneous abortion rate, and preterm birth rate. After adjustments for a series of potential confounding factors, the previous STP was an influential factor in reducing FET cycle clinical pregnancy rate compared with women who had not previously undergone STP (OR = 0.614, 95% CI 0.413–0.911, P = 0.016). The effect of the previous STP on the live birth rate was not statistically significant. (OR = 0.745, 95% CI 0.495–1.122, P = 0.159). Also, an increase in the number of previous STPs relative to only 1-time abortion was an independent risk factor in reducing clinical pregnancy rate and live birth rate (OR = 0.399,95% CI 0.162–0.982, p = 0.046; OR = 0.32,95% CI 0.119–0.857, p = 0.023). Previous STP was an independent factor contributing to the decline in FET cycle clinical pregnancy rates. |
| first_indexed | 2024-04-24T19:56:37Z |
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| id | doaj.art-f8fa90c5ac4944109bb05338fa547830 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T19:56:37Z |
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| spelling | doaj.art-f8fa90c5ac4944109bb05338fa5478302024-03-24T12:19:30ZengNature PortfolioScientific Reports2045-23222024-03-0114111010.1038/s41598-024-57377-4Association between previous surgical termination of pregnancy and pregnancy outcomes in frozen-thawed embryo transfer cycles of IVF/ICSI: a retrospective cohort studyShuai Zhang0Hanhan Tang1Minglian Zhou2Clinical Center of Reproductive Medicine, Lianyungang Maternal and Child Health HospitalGraduate School of Xuzhou Medical University, Xuzhou Medical UniversityClinical Center of Reproductive Medicine, Lianyungang Maternal and Child Health HospitalAbstract This study aimed to evaluate the effect of previous surgical termination of pregnancy (STP) on pregnancy outcomes in women undergoing FET cycles of IVF/ICSI. Retrospective cohort study. Reproductive Center of Maternal and Child Health Care Hospital in Lianyungang city. Data were selected from all IVF/ICSI FET cycles performed between January 2014 and December 2020. A total of 761 cycles met the criteria were included in this study. The primary outcome measures were clinical pregnancy and live birth rates. Secondary outcome measures were biochemical pregnancy rate, spontaneous abortion rate, and preterm birth rate. After adjustments for a series of potential confounding factors, the previous STP was an influential factor in reducing FET cycle clinical pregnancy rate compared with women who had not previously undergone STP (OR = 0.614, 95% CI 0.413–0.911, P = 0.016). The effect of the previous STP on the live birth rate was not statistically significant. (OR = 0.745, 95% CI 0.495–1.122, P = 0.159). Also, an increase in the number of previous STPs relative to only 1-time abortion was an independent risk factor in reducing clinical pregnancy rate and live birth rate (OR = 0.399,95% CI 0.162–0.982, p = 0.046; OR = 0.32,95% CI 0.119–0.857, p = 0.023). Previous STP was an independent factor contributing to the decline in FET cycle clinical pregnancy rates.https://doi.org/10.1038/s41598-024-57377-4Freeze–thaw embryo transferInduced termination of pregnancyInduced abortionEndometriumInfertility |
| spellingShingle | Shuai Zhang Hanhan Tang Minglian Zhou Association between previous surgical termination of pregnancy and pregnancy outcomes in frozen-thawed embryo transfer cycles of IVF/ICSI: a retrospective cohort study Scientific Reports Freeze–thaw embryo transfer Induced termination of pregnancy Induced abortion Endometrium Infertility |
| title | Association between previous surgical termination of pregnancy and pregnancy outcomes in frozen-thawed embryo transfer cycles of IVF/ICSI: a retrospective cohort study |
| title_full | Association between previous surgical termination of pregnancy and pregnancy outcomes in frozen-thawed embryo transfer cycles of IVF/ICSI: a retrospective cohort study |
| title_fullStr | Association between previous surgical termination of pregnancy and pregnancy outcomes in frozen-thawed embryo transfer cycles of IVF/ICSI: a retrospective cohort study |
| title_full_unstemmed | Association between previous surgical termination of pregnancy and pregnancy outcomes in frozen-thawed embryo transfer cycles of IVF/ICSI: a retrospective cohort study |
| title_short | Association between previous surgical termination of pregnancy and pregnancy outcomes in frozen-thawed embryo transfer cycles of IVF/ICSI: a retrospective cohort study |
| title_sort | association between previous surgical termination of pregnancy and pregnancy outcomes in frozen thawed embryo transfer cycles of ivf icsi a retrospective cohort study |
| topic | Freeze–thaw embryo transfer Induced termination of pregnancy Induced abortion Endometrium Infertility |
| url | https://doi.org/10.1038/s41598-024-57377-4 |
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