Health-related quality of life in T1DM patients after high-dose cholecalciferol supplementation: data from a pilot clinical trial
Abstract Background Type 1 Diabetes Mellitus (T1DM) impacts health-related quality of life (HRQoL). Cross-sectional studies suggest that low levels of vitamin D (VD) may impair HRQoL, however, the effect of VD supplementation on quality of life in T1DM patients has not yet been clarified. Our study...
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-03-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13098-022-00817-w |
| _version_ | 1811311699946373120 |
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| author | Ana Carolina Contente Braga de Souza Maria Clara Neres Iunes de Oliveira Gabriela Nascimento de Lemos Emanuele Rocha da Silva Ícaro José Araújo de Souza Wanderson Maia da Silva Angélica Leite de Alcântara Nivin Mazen Said Lorena Vilhena de Moraes João Felício Abrahão Neto Simone Rodrigues dos Passos Ádria Aline Alves Monteiro Natércia Neves Marques de Queiroz Franciane Trindade Cunha de Melo Karem Miléo Felício Lilian de Souza D’Albuquerque Silva Daniela Lopes Gomes Neyla Arroyo Lara Mourão Pedro Paulo Freire Piani Isabel Jane Campos Lobato João Soares Felício |
| author_facet | Ana Carolina Contente Braga de Souza Maria Clara Neres Iunes de Oliveira Gabriela Nascimento de Lemos Emanuele Rocha da Silva Ícaro José Araújo de Souza Wanderson Maia da Silva Angélica Leite de Alcântara Nivin Mazen Said Lorena Vilhena de Moraes João Felício Abrahão Neto Simone Rodrigues dos Passos Ádria Aline Alves Monteiro Natércia Neves Marques de Queiroz Franciane Trindade Cunha de Melo Karem Miléo Felício Lilian de Souza D’Albuquerque Silva Daniela Lopes Gomes Neyla Arroyo Lara Mourão Pedro Paulo Freire Piani Isabel Jane Campos Lobato João Soares Felício |
| author_sort | Ana Carolina Contente Braga de Souza |
| collection | DOAJ |
| description | Abstract Background Type 1 Diabetes Mellitus (T1DM) impacts health-related quality of life (HRQoL). Cross-sectional studies suggest that low levels of vitamin D (VD) may impair HRQoL, however, the effect of VD supplementation on quality of life in T1DM patients has not yet been clarified. Our study evaluated the effects of high-dose VD supplementation on HRQoL in T1DM. Methods We performed a prospective study with 64 patients receiving cholecalciferol (4000 IU/day for patients with 25-OH-vitamin D [25(OH)D] between 30 and 60 ng/mL, and 10,000 IU/day for those with 25(OH)D below 30 ng/mL) for 12 weeks, as part of a research protocol. HRQoL was assessed with EuroQol instruments (EQ-5D and EQ-VAS). Results There was an improvement in global EQ-5D index, and analysing specifically the EQ-5D domains, we observed an improvement in mobility (1.3 ± 0.6 versus 1.1 ± 0.3, p < 0.01). Evaluating possible outcome influencing variables, we detected a reduction in albuminuria at the end of the trial, without changes in BMI, lipids, blood pressure, glycemic control and insulin doses. We found correlations between final albuminuria and the dimensions: mobility (r = 0.6; p < 0.01), personal care (r = 0.7; p < 0.01), pain and discomfort (r = 0.6; p < 0.01) and habitual activities (r = 0.6; p < 0.01), suggesting an association between albuminuria reduction and the impact of VD supplementation on HRQoL. Conclusion Our data showed that high doses of cholecalciferol supplementation can improve HRQoL in patients with T1DM, and the reduction of albuminuria seems to be an important factor in this context. Trial registration: (ISRCTN32601947), 03/06/2017 retrospectively registered. |
| first_indexed | 2024-04-13T10:23:31Z |
| format | Article |
| id | doaj.art-f8fc470fdd4b44789bdd433cbd2e0543 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-13T10:23:31Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-f8fc470fdd4b44789bdd433cbd2e05432022-12-22T02:50:26ZengBMCDiabetology & Metabolic Syndrome1758-59962022-03-011411810.1186/s13098-022-00817-wHealth-related quality of life in T1DM patients after high-dose cholecalciferol supplementation: data from a pilot clinical trialAna Carolina Contente Braga de Souza0Maria Clara Neres Iunes de Oliveira1Gabriela Nascimento de Lemos2Emanuele Rocha da Silva3Ícaro José Araújo de Souza4Wanderson Maia da Silva5Angélica Leite de Alcântara6Nivin Mazen Said7Lorena Vilhena de Moraes8João Felício Abrahão Neto9Simone Rodrigues dos Passos10Ádria Aline Alves Monteiro11Natércia Neves Marques de Queiroz12Franciane Trindade Cunha de Melo13Karem Miléo Felício14Lilian de Souza D’Albuquerque Silva15Daniela Lopes Gomes16Neyla Arroyo Lara Mourão17Pedro Paulo Freire Piani18Isabel Jane Campos Lobato19João Soares Felício20Endocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáEndocrinology Division, University Hospital João de Barros Barreto, Federal University of ParáAbstract Background Type 1 Diabetes Mellitus (T1DM) impacts health-related quality of life (HRQoL). Cross-sectional studies suggest that low levels of vitamin D (VD) may impair HRQoL, however, the effect of VD supplementation on quality of life in T1DM patients has not yet been clarified. Our study evaluated the effects of high-dose VD supplementation on HRQoL in T1DM. Methods We performed a prospective study with 64 patients receiving cholecalciferol (4000 IU/day for patients with 25-OH-vitamin D [25(OH)D] between 30 and 60 ng/mL, and 10,000 IU/day for those with 25(OH)D below 30 ng/mL) for 12 weeks, as part of a research protocol. HRQoL was assessed with EuroQol instruments (EQ-5D and EQ-VAS). Results There was an improvement in global EQ-5D index, and analysing specifically the EQ-5D domains, we observed an improvement in mobility (1.3 ± 0.6 versus 1.1 ± 0.3, p < 0.01). Evaluating possible outcome influencing variables, we detected a reduction in albuminuria at the end of the trial, without changes in BMI, lipids, blood pressure, glycemic control and insulin doses. We found correlations between final albuminuria and the dimensions: mobility (r = 0.6; p < 0.01), personal care (r = 0.7; p < 0.01), pain and discomfort (r = 0.6; p < 0.01) and habitual activities (r = 0.6; p < 0.01), suggesting an association between albuminuria reduction and the impact of VD supplementation on HRQoL. Conclusion Our data showed that high doses of cholecalciferol supplementation can improve HRQoL in patients with T1DM, and the reduction of albuminuria seems to be an important factor in this context. Trial registration: (ISRCTN32601947), 03/06/2017 retrospectively registered.https://doi.org/10.1186/s13098-022-00817-wType 1 diabetes mellitusQuality of lifeVitamin DAlbuminuria |
| spellingShingle | Ana Carolina Contente Braga de Souza Maria Clara Neres Iunes de Oliveira Gabriela Nascimento de Lemos Emanuele Rocha da Silva Ícaro José Araújo de Souza Wanderson Maia da Silva Angélica Leite de Alcântara Nivin Mazen Said Lorena Vilhena de Moraes João Felício Abrahão Neto Simone Rodrigues dos Passos Ádria Aline Alves Monteiro Natércia Neves Marques de Queiroz Franciane Trindade Cunha de Melo Karem Miléo Felício Lilian de Souza D’Albuquerque Silva Daniela Lopes Gomes Neyla Arroyo Lara Mourão Pedro Paulo Freire Piani Isabel Jane Campos Lobato João Soares Felício Health-related quality of life in T1DM patients after high-dose cholecalciferol supplementation: data from a pilot clinical trial Diabetology & Metabolic Syndrome Type 1 diabetes mellitus Quality of life Vitamin D Albuminuria |
| title | Health-related quality of life in T1DM patients after high-dose cholecalciferol supplementation: data from a pilot clinical trial |
| title_full | Health-related quality of life in T1DM patients after high-dose cholecalciferol supplementation: data from a pilot clinical trial |
| title_fullStr | Health-related quality of life in T1DM patients after high-dose cholecalciferol supplementation: data from a pilot clinical trial |
| title_full_unstemmed | Health-related quality of life in T1DM patients after high-dose cholecalciferol supplementation: data from a pilot clinical trial |
| title_short | Health-related quality of life in T1DM patients after high-dose cholecalciferol supplementation: data from a pilot clinical trial |
| title_sort | health related quality of life in t1dm patients after high dose cholecalciferol supplementation data from a pilot clinical trial |
| topic | Type 1 diabetes mellitus Quality of life Vitamin D Albuminuria |
| url | https://doi.org/10.1186/s13098-022-00817-w |
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