Fibrinogen–Albumin Ratio Index Exhibits Predictive Value of Neoadjuvant Chemotherapy in Osteosarcoma
Zhendong Li,1,* Chenliang Zhou,2,* Qing Peng,3,* Suguo Wang,3 Guowei Qian,2 Lina Tang,2 Xin Zhou,4 Qingcheng Yang,1 Zan Shen,2 GaoZhong Huang,3 Yonggang Wang,2 Hongtao Li2 1Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai,...
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| Format: | Article |
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Dove Medical Press
2022-05-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/fibrinogenalbumin-ratio-index-exhibits-predictive-value-of-neoadjuvant-peer-reviewed-fulltext-article-CMAR |
| _version_ | 1818206541704069120 |
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| author | Li Z Zhou C Peng Q Wang SG Qian G Tang L Zhou X Yang Q Shen Z Huang GZ Wang Y Li H |
| author_facet | Li Z Zhou C Peng Q Wang SG Qian G Tang L Zhou X Yang Q Shen Z Huang GZ Wang Y Li H |
| author_sort | Li Z |
| collection | DOAJ |
| description | Zhendong Li,1,* Chenliang Zhou,2,* Qing Peng,3,* Suguo Wang,3 Guowei Qian,2 Lina Tang,2 Xin Zhou,4 Qingcheng Yang,1 Zan Shen,2 GaoZhong Huang,3 Yonggang Wang,2 Hongtao Li2 1Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China; 2Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China; 3Department of VIP Clinic, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China; 4Cancer Research Institute of Jilin University, the First Hospital of Jilin University, Changchun, Jilin, 130021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yonggang Wang; Hongtao Li, Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, No. 600, Yishan Road, Xu Hui District, Shanghai, 200233, People’s Republic of China, Tel +086-021-24058408, Email sirui666@163.com; Lhtmed@126.comPurpose: Inflammatory response and nutritional status are associated with cancer development and progression. The present study aimed to evaluate the predictive ability of the fibrinogen–albumin ratio index (FARI) to the efficacy of neoadjuvant chemotherapy (NAC) for osteosarcoma.Patients and methods: A retrospective analysis involving 752 consecutive osteosarcoma patients between 2012 and 2020 was performed. Data on serum fibrinogen, albumin levels, white blood cell count, platelet count, and alkaline phosphatase (ALP) before and after NAC were collected. The predictive value of the NAC efficacy in osteosarcoma was assessed by constructing a receiver operating characteristic (ROC) curve and calculating the area under the curve (AUC). Prognosis and its predictive factors were analyzed by Kaplan–Meier method and COX regression analysis. Nomogram was established according to selected variables. The predictive performance of the nomogram model was assessed using C-statistics.Results: A total of 203 patients were included. ROC analysis showed that both FARI before NAC (preFARI; AUC = 0.594, p = 0.032) and the change in FARI before and after NAC (dfFARI = preFARI-postFARI; AUC = 0.652, p = 0.001) exhibited more favorable predictive ability than ALP and other inflammation markers. The preFARI was divided into the high group (> 6.1%) and the low group (≤ 6.1%) based on the optimal cut-off value of 6.1%. Patients with a high preFARI showed significantly decreased metastasis-free survival (MFS) and disease-free survival (DFS) (all p< 0.01). In multivariable analysis, preFARI was an independent prognostic marker for patients with osteosarcoma. Predictive nomograms exhibited good ability to predict MFS (C-index = 0.748, se = 0.028) and DFS (C-index=0.727, se = 0.030).Conclusion: Our findings indicated that FARI exhibits the favorable predictive ability for the efficacy of NAC for osteosarcoma, which could support clinicians and patients in clinical decision-making and treatment optimization.Keywords: osteosarcoma, neoadjuvant chemotherapy, fibrinogen, albumin, fibrinogen–albumin ratio index, prognosis |
| first_indexed | 2024-12-12T04:14:40Z |
| format | Article |
| id | doaj.art-f8fcf6476f80448bb6d63d5f7b6908d0 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-12T04:14:40Z |
| publishDate | 2022-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-f8fcf6476f80448bb6d63d5f7b6908d02022-12-22T00:38:30ZengDove Medical PressCancer Management and Research1179-13222022-05-01Volume 141671168275083Fibrinogen–Albumin Ratio Index Exhibits Predictive Value of Neoadjuvant Chemotherapy in OsteosarcomaLi ZZhou CPeng QWang SGQian GTang LZhou XYang QShen ZHuang GZWang YLi HZhendong Li,1,* Chenliang Zhou,2,* Qing Peng,3,* Suguo Wang,3 Guowei Qian,2 Lina Tang,2 Xin Zhou,4 Qingcheng Yang,1 Zan Shen,2 GaoZhong Huang,3 Yonggang Wang,2 Hongtao Li2 1Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China; 2Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China; 3Department of VIP Clinic, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China; 4Cancer Research Institute of Jilin University, the First Hospital of Jilin University, Changchun, Jilin, 130021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yonggang Wang; Hongtao Li, Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, No. 600, Yishan Road, Xu Hui District, Shanghai, 200233, People’s Republic of China, Tel +086-021-24058408, Email sirui666@163.com; Lhtmed@126.comPurpose: Inflammatory response and nutritional status are associated with cancer development and progression. The present study aimed to evaluate the predictive ability of the fibrinogen–albumin ratio index (FARI) to the efficacy of neoadjuvant chemotherapy (NAC) for osteosarcoma.Patients and methods: A retrospective analysis involving 752 consecutive osteosarcoma patients between 2012 and 2020 was performed. Data on serum fibrinogen, albumin levels, white blood cell count, platelet count, and alkaline phosphatase (ALP) before and after NAC were collected. The predictive value of the NAC efficacy in osteosarcoma was assessed by constructing a receiver operating characteristic (ROC) curve and calculating the area under the curve (AUC). Prognosis and its predictive factors were analyzed by Kaplan–Meier method and COX regression analysis. Nomogram was established according to selected variables. The predictive performance of the nomogram model was assessed using C-statistics.Results: A total of 203 patients were included. ROC analysis showed that both FARI before NAC (preFARI; AUC = 0.594, p = 0.032) and the change in FARI before and after NAC (dfFARI = preFARI-postFARI; AUC = 0.652, p = 0.001) exhibited more favorable predictive ability than ALP and other inflammation markers. The preFARI was divided into the high group (> 6.1%) and the low group (≤ 6.1%) based on the optimal cut-off value of 6.1%. Patients with a high preFARI showed significantly decreased metastasis-free survival (MFS) and disease-free survival (DFS) (all p< 0.01). In multivariable analysis, preFARI was an independent prognostic marker for patients with osteosarcoma. Predictive nomograms exhibited good ability to predict MFS (C-index = 0.748, se = 0.028) and DFS (C-index=0.727, se = 0.030).Conclusion: Our findings indicated that FARI exhibits the favorable predictive ability for the efficacy of NAC for osteosarcoma, which could support clinicians and patients in clinical decision-making and treatment optimization.Keywords: osteosarcoma, neoadjuvant chemotherapy, fibrinogen, albumin, fibrinogen–albumin ratio index, prognosishttps://www.dovepress.com/fibrinogenalbumin-ratio-index-exhibits-predictive-value-of-neoadjuvant-peer-reviewed-fulltext-article-CMARosteosarcomaneoadjuvant chemotherapyfibrinogenalbuminfibrinogen-albumin ratio indexprognosis. |
| spellingShingle | Li Z Zhou C Peng Q Wang SG Qian G Tang L Zhou X Yang Q Shen Z Huang GZ Wang Y Li H Fibrinogen–Albumin Ratio Index Exhibits Predictive Value of Neoadjuvant Chemotherapy in Osteosarcoma Cancer Management and Research osteosarcoma neoadjuvant chemotherapy fibrinogen albumin fibrinogen-albumin ratio index prognosis. |
| title | Fibrinogen–Albumin Ratio Index Exhibits Predictive Value of Neoadjuvant Chemotherapy in Osteosarcoma |
| title_full | Fibrinogen–Albumin Ratio Index Exhibits Predictive Value of Neoadjuvant Chemotherapy in Osteosarcoma |
| title_fullStr | Fibrinogen–Albumin Ratio Index Exhibits Predictive Value of Neoadjuvant Chemotherapy in Osteosarcoma |
| title_full_unstemmed | Fibrinogen–Albumin Ratio Index Exhibits Predictive Value of Neoadjuvant Chemotherapy in Osteosarcoma |
| title_short | Fibrinogen–Albumin Ratio Index Exhibits Predictive Value of Neoadjuvant Chemotherapy in Osteosarcoma |
| title_sort | fibrinogen ndash albumin ratio index exhibits predictive value of neoadjuvant chemotherapy in osteosarcoma |
| topic | osteosarcoma neoadjuvant chemotherapy fibrinogen albumin fibrinogen-albumin ratio index prognosis. |
| url | https://www.dovepress.com/fibrinogenalbumin-ratio-index-exhibits-predictive-value-of-neoadjuvant-peer-reviewed-fulltext-article-CMAR |
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