TGF-β2 Regulates Transcription of the K<sup>+</sup>/Cl<sup>−</sup> Cotransporter 2 (KCC2) in Immature Neurons and Its Phosphorylation at T1007 in Differentiated Neurons

TGF-β2 Regulates Transcription of the K<sup>+</sup>/Cl<sup>−</sup> Cotransporter 2 (KCC2) in Immature Neurons and Its Phosphorylation at T1007 in Differentiated Neurons

KCC2 mediates extrusion of K<sup>+</sup> and Cl<sup>−</sup> and assuresthe developmental “switch” in GABA function during neuronal maturation. However, the molecular mechanisms underlying KCC2 regulation are not fully elucidated. We investigated the impact of transforming gro...

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Bibliographic Details
Main Authors: Anastasia Rigkou, Attila Magyar, Jan Manuel Speer, Eleni Roussa
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
neurotrophins
GABA
growth factors
chloride homeostasis
pre-Bötzinger complex
Online Access:https://www.mdpi.com/2073-4409/11/23/3861

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