Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells

Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells

Mutations in genes encoding cytochrome c oxidase (mitochondrial complex IV) subunits and assembly factors [e.g., synthesis of cytochrome c oxidase 2 (SCO2)] are linked to severe metabolic syndromes. Notwithstanding that SCO2 is under transcriptional control of tumor suppressor p53, the role of mitoc...

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Bibliographic Details
Main Authors: Oro Uchenunu, Alexander V. Zhdanov, Phillipe Hutton, Predrag Jovanovic, Ye Wang, Dmitry E. Andreev, Laura Hulea, David J. Papadopoli, Daina Avizonis, Pavel V. Baranov, Michael N. Pollak, Dmitri B. Papkovsky, Ivan Topisirovic
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:FEBS Open Bio
Subjects:
AKT
AMPK
cytochrome C oxidase
metabolism
mitochondrial dysfunction
mTOR
Online Access:https://doi.org/10.1002/2211-5463.13398

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