Amyloid-beta and tau protein beyond Alzheimer’s disease
The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer’s disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. Physiologically, these two proteins are produced and expressed within the normal...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=6;spage=1262;epage=1276;aulast=Abyadeh |
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| author | Morteza Abyadeh Vivek Gupta Joao A Paulo Arezoo Gohari Mahmoudabad Sina Shadfar Shahab Mirshahvaladi Veer Gupta Christine T O. Nguyen David I Finkelstein Yuyi You Paul A Haynes Ghasem H Salekdeh Stuart L Graham Mehdi Mirzaei |
| author_facet | Morteza Abyadeh Vivek Gupta Joao A Paulo Arezoo Gohari Mahmoudabad Sina Shadfar Shahab Mirshahvaladi Veer Gupta Christine T O. Nguyen David I Finkelstein Yuyi You Paul A Haynes Ghasem H Salekdeh Stuart L Graham Mehdi Mirzaei |
| author_sort | Morteza Abyadeh |
| collection | DOAJ |
| description | The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer’s disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. Physiologically, these two proteins are produced and expressed within the normal human body. However, under pathological conditions, abnormal expression, post-translational modifications, conformational changes, and truncation can make these proteins prone to aggregation, triggering specific disease-related cascades. Recent studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, as well as retinal neurodegenerative diseases like Glaucoma and age-related macular degeneration. Additionally, these proteins have been linked to cardiovascular disease, cancer, traumatic brain injury, and diabetes, which are all leading causes of morbidity and mortality. In this comprehensive review, we provide an overview of the connections between amyloid-beta and tau proteins and a spectrum of disorders. |
| first_indexed | 2024-04-24T15:49:49Z |
| format | Article |
| id | doaj.art-f8fe9e44ce7e49208ce6a071ba24f39c |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-24T15:49:49Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-f8fe9e44ce7e49208ce6a071ba24f39c2024-04-01T13:05:59ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742024-01-011961262127610.4103/1673-5374.386406Amyloid-beta and tau protein beyond Alzheimer’s diseaseMorteza AbyadehVivek GuptaJoao A PauloArezoo Gohari MahmoudabadSina ShadfarShahab MirshahvaladiVeer GuptaChristine T O. NguyenDavid I FinkelsteinYuyi YouPaul A HaynesGhasem H SalekdehStuart L GrahamMehdi MirzaeiThe aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer’s disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. Physiologically, these two proteins are produced and expressed within the normal human body. However, under pathological conditions, abnormal expression, post-translational modifications, conformational changes, and truncation can make these proteins prone to aggregation, triggering specific disease-related cascades. Recent studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, as well as retinal neurodegenerative diseases like Glaucoma and age-related macular degeneration. Additionally, these proteins have been linked to cardiovascular disease, cancer, traumatic brain injury, and diabetes, which are all leading causes of morbidity and mortality. In this comprehensive review, we provide an overview of the connections between amyloid-beta and tau proteins and a spectrum of disorders.http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=6;spage=1262;epage=1276;aulast=Abyadehamyloid-beta; cancer; cardiovascular diseases; diabetes; neurodegeneration; tau; traumatic brain injury |
| spellingShingle | Morteza Abyadeh Vivek Gupta Joao A Paulo Arezoo Gohari Mahmoudabad Sina Shadfar Shahab Mirshahvaladi Veer Gupta Christine T O. Nguyen David I Finkelstein Yuyi You Paul A Haynes Ghasem H Salekdeh Stuart L Graham Mehdi Mirzaei Amyloid-beta and tau protein beyond Alzheimer’s disease Neural Regeneration Research amyloid-beta; cancer; cardiovascular diseases; diabetes; neurodegeneration; tau; traumatic brain injury |
| title | Amyloid-beta and tau protein beyond Alzheimer’s disease |
| title_full | Amyloid-beta and tau protein beyond Alzheimer’s disease |
| title_fullStr | Amyloid-beta and tau protein beyond Alzheimer’s disease |
| title_full_unstemmed | Amyloid-beta and tau protein beyond Alzheimer’s disease |
| title_short | Amyloid-beta and tau protein beyond Alzheimer’s disease |
| title_sort | amyloid beta and tau protein beyond alzheimer s disease |
| topic | amyloid-beta; cancer; cardiovascular diseases; diabetes; neurodegeneration; tau; traumatic brain injury |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=6;spage=1262;epage=1276;aulast=Abyadeh |
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