Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts
The preliminary analyses on a multiscale model of intestinal crypt dynamics are here presented. The model combines a morphological model, based on the Cellular Potts Model (CPM), and a gene regulatory network model, based on Noisy Random Boolean Networks (NRBNs). Simulations suggest that the stochas...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Open Publishing Association
2013-09-01
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| Series: | Electronic Proceedings in Theoretical Computer Science |
| Online Access: | http://arxiv.org/pdf/1309.7693v1 |
| _version_ | 1830212530734104576 |
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| author | Marco Antoniotti Giulio Caravagna Alex Graudenzi Giovanni de Matteis |
| author_facet | Marco Antoniotti Giulio Caravagna Alex Graudenzi Giovanni de Matteis |
| author_sort | Marco Antoniotti |
| collection | DOAJ |
| description | The preliminary analyses on a multiscale model of intestinal crypt dynamics are here presented. The model combines a morphological model, based on the Cellular Potts Model (CPM), and a gene regulatory network model, based on Noisy Random Boolean Networks (NRBNs). Simulations suggest that the stochastic differentiation process is itself sufficient to ensure the general homeostasis in the asymptotic states, as proven by several measures. |
| first_indexed | 2024-12-18T06:04:14Z |
| format | Article |
| id | doaj.art-f90104d9dddc465e97bee4c756ae2467 |
| institution | Directory Open Access Journal |
| issn | 2075-2180 |
| language | English |
| last_indexed | 2024-12-18T06:04:14Z |
| publishDate | 2013-09-01 |
| publisher | Open Publishing Association |
| record_format | Article |
| series | Electronic Proceedings in Theoretical Computer Science |
| spelling | doaj.art-f90104d9dddc465e97bee4c756ae24672022-12-21T21:18:36ZengOpen Publishing AssociationElectronic Proceedings in Theoretical Computer Science2075-21802013-09-01130Proc. Wivace 2013798210.4204/EPTCS.130.12Analysis of the spatial and dynamical properties of a multiscale model of intestinal cryptsMarco AntoniottiGiulio CaravagnaAlex GraudenziGiovanni de MatteisThe preliminary analyses on a multiscale model of intestinal crypt dynamics are here presented. The model combines a morphological model, based on the Cellular Potts Model (CPM), and a gene regulatory network model, based on Noisy Random Boolean Networks (NRBNs). Simulations suggest that the stochastic differentiation process is itself sufficient to ensure the general homeostasis in the asymptotic states, as proven by several measures.http://arxiv.org/pdf/1309.7693v1 |
| spellingShingle | Marco Antoniotti Giulio Caravagna Alex Graudenzi Giovanni de Matteis Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts Electronic Proceedings in Theoretical Computer Science |
| title | Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts |
| title_full | Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts |
| title_fullStr | Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts |
| title_full_unstemmed | Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts |
| title_short | Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts |
| title_sort | analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts |
| url | http://arxiv.org/pdf/1309.7693v1 |
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